The surface of Toxoplasma tachyzoites is dominated by a family of glycosylphosphatidylinositol-anchored antigens related to SAG1

Infection and Immunity

Volumn 66, Issue 5, 1998, Pages 2237-2244

  Manger, Ian D ^a   Hehl, Adrian B ^a   Boothroyd, John C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLPHOSPHATIDYLINOSITOL; PARASITE ANTIGEN; SURFACE ANTIGEN 1; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; GENE EXPRESSION; IMMUNE RESPONSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; TOXOPLASMA GONDII;

EID: 0031949214     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.5.2237-2244.1998     Document Type: Article

References (36)

1. Ajioka, J., J. C. Boothroyd, B. P. Brunk, A. Hehl, L. Hillier, I. D. Manger, G. C. Overton, M. Marra, D. Roos, K. L. Wan, R. Waterston, and L. D. Sibley. 1998. Sequencing of ESTs from the protozoan parasite Toxoplasma gondii: efficient identification of genes and identification of phylogenetically restricted sequences of the Apicomplexa. Genome Res. 8:18-28.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1995. Current protocols in molecular biology, vol. 1 to 3. John Wiley and Sons, Inc., New York, N.Y.
3. Bulow, R., and J. C. Boothroyd. 1991. Protection of mice from fatal Toxoplasma gondii infection by immunization with P30 antigen in liposomes. J. Immunol. 147:3496-3500.
4. Burg, J. L., D. Perelman, L. H. Kasper, P. L. Ware, and J. C. Boothroyd. 1988. Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii. J. Immunol. 141:3584-3591.
5. Cesbron-Delauw, M. F., S. Tomavo, P. Beauchamps, M. P. Fourmaux, D. Camus, A. Capron, and J. F. Dubremetz. 1994. Similarities between the primary structures of two distinct major surface proteins of Toxoplasma gondii. J. Biol. Chem. 269:16217-16222.
6. Couvreur, G., A. Sadak, B. Fortier, and J. F. Dubremetz. 1988. Surface antigens of Toxoplasma gondii. Parasitology 97:1-10.
7. Cross, G. A. M. 1990. Cellular and genetic aspects of antigenic variation in trypanosomes. Annu. Rev. Immunol. 8:83-110.
8. Gilbert, S. C., M. Plebanski, S. Gupta, J. Morris, M. Cox, M. Aidoo, D. Kwiatkowski, B. M. Greenwood, H. C. Whittle, and A. V. S. Hill. 1998. Association of malaria parasite population structure, HLA, and immunological antagonism. Science 279:1173-1177.
9. Grimwood, J., and J. E. Smith. 1992. Toxoplasma gondii: the role of a 30-kDa surface protein in host cell invasion. Exp. Parasitol. 74:106-111.
10. Hehl, A. B., T. Krieger, and J. C. Boothroyd. 1997. Identification and characterization of SRS1. a Toxoplasma gondii surface antigen upstream of and related to SAG1. Mol. Biochcm. Parasitol. 89:271-282.
11. Kahn, S. J., and M. Wleklinski. 1997. The surface glycoproteins of Trypanosoma cruzi encode a superfamily of variant T cell epitopes. J. Immunol. 159:4444-4451.
12. Kasper, L. H. 1987. Isolation and characterization of a monoclonal anti-P30 antibody resistant mutant of Toxoplasma gondii. Parasite Immunol. 9:433-445.
13. Kasper, L. H., and I. A. Khan. 1993. Role of P30 in host immunity and pathogenesis of Toxoplasma gondii infection. Res. Immunol. 144:45-18.
14. Kasper, L. H., and P. L. Ware. 1985. Recognition and characterization of stage-specific oocyst/sporozoite antigens of Toxoplasma gondii by human antisera. J. Clin. Invest. 75:1570-1577.
15. Khan, I. A., K. H. Ely, and L. H. Kasper. 1991. A purified parasite antigen (P30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice. J. Immunol. 147:3501-3506.
16. Knoll, L. J., and J. C. Boothroyd. 1998. Isolation of developmentally regulated genes from Toxoplasma gondii by a gene trap with the positive and negative selectable marker hypoxanthine-xanthine-guanine phosphoribosyl-transferase. Mol. Cell. Biol. 18:807-814.
17. Manger, I. D., A. B. Hehl, and J. C. Boothroyd. Unpublished data
18. Manger, I. D., A. Hehl, S. Parmley, L. D. Sibley, M. Marra, L. Hillier, R. Waterston, and J. C. Boothroyd. 1998. Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes. Infect. Immun. 66:1632-1637.
19. Mineo, J. R., R. McLeod, D. Mack, J. Smith, I. A. Khan, K. H. Ely, and L. H. Kasper. 1993. Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and arc produced in murine intestine after peroral infection. J. Immunol. 150:3951-3964.
20. Nagel, S. D., and J. C. Boothroyd. 1989. The major surface antigen, P30, of Toxoplasma gondii is anchored by a glycolipid. J. Biol. Chem. 264:5569-5574.
21. Newbold, C. I., A. G. Craig, S. Kyes, A. R. Benendt, R. W. Snow, N, Peshu, and K. Marsh. 1997. Pfemp1, polymorphism and pathogenesis. Ann. Trop. Med. Parasitol. 91:551-557.
22. Odberg-Ferragut, C., M. Soete, A. Engels, B. Samyn, A. Loyens, J. Van Beeumen, D. Camus, and J. F. Dubremetz. 1996. Molecular cloning of the Toxoplasma gondii sag4 gene encoding an 18 kDa bradyzoite specific surface protein. Mol. Biochcm. Parasitol. 82:237-244.
23. Parmley, S, F., G. D. Sgarlato, J. Mark, J. B. Prince, and J. S. Remington. 1992. Expression, characterization, and serologic reactivity of recombinant surface antigen P22 of Toxoplasma gondii. J. Clin. Microhiol. 30:1127-1133.
24. Pfefferkorn, E. R., L. C. Pfefferkorn, and E. D. Colby. 1977. Development of gametes and oocysts in cats fed cysts derived from cloned trophozoites of Toxoplasma gondii. J. Parasitol. 63:158-159.
25. Riggs, P. 1994. Expression and purification of maltose-binding protein fusions, p. 16.6.1-16.6.14. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley and Sons, Inc., New York, N.Y.
26. Sabin, A. B. 1941 Toxoplasmic encephalitis in children. JAMA 116:801-807.
27. Shak, S., M. A. Davitz, M. L. Wolinsky, V. Nussenzweig, M. J. Turner, and A. Gurnett. 1988. Partial characterization of the cross-reacting determinant, a carbohydrate epitope shared by decay accelerating factor and the variant surface glycoprotein of the African Trypanosoma brucei. J. Immunol. 140: 2046-2050.
28. Sibley, L. D. 1995. Invasion of vertebrate cells by Toxoplasma gondii. Trends Cell Biol. 5:129-132.
29. Spano, F. Personal communication.
30. Tomavo, S. 1996. The major surface proteins of Toxoplasma gondii: structures and functions. Curr. Top. Microbiol. Immunol. 219:45-54.
31. Tomavo, S., B. Fortier, M. Soete, C. Ansel, D. Camus, and J. F. Dubremetz. 1991. Characterization of bradyzoite-specific antigens of Toxoplasma gondii. Infect. Immun. 59:3750-3753.
32. Tomavo, S., R. T. Schwarz, and J. F. Dubremetz. 1989. Evidence for glycosylphosphatidylinositol anchoring of Toxoplasma gondii major surface antigens. Mol. Cell. Biol. 9:4576-4580.
33. Udenfriend, S., and K. Kodukula. 1995. How glycosylphosphatidylinositol-anchored proteins are made. Annu. Rev. Biochem. 64:563-592.
34. von Heijne, G. 1986. A new method for predicting signal sequence cleavage sites. Nucleic Acids Res. 14:4683-4690.
35. Wan, K. L., J. M. Blackwell, and J. W. Ajioka. 1996. Toxoplasma gondii expressed sequence tags: insight into tachyzoite gene. Mol. Biochem. Parasitol. 75:179-186.
36. Ware, P. L., and L. H. Kasper. 1987. Strain-specific antigens of Toxoplasma gondii. Infect. Immun. 55:778-783.