Divergent effects of endogenous and exogenous glucocorticoid-induced leucine zipper in animal models of inflammation and arthritis

Arthritis and Rheumatism

Volumn 65, Issue 5, 2013, Pages 1203-1212

  Ngo, Devi ^a   Beaulieu, Elaine ^a   Gu, Ran ^a   Leaney, Alexandra ^a   Santos, Leilani ^a   Fan, Huapeng ^a   Yang, Yuanhang ^a   Kao, Wenping ^a   Xu, Jiake ^b   Escriou, Virginie ^c   Loiler, Scott ^d   Vervoordeldonk, Margriet J ^e   Morand, Eric F ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c INSERM   (France)

^d Arthrogen BV   (Netherlands)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID INDUCED LEUCINE ZIPPER; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUCINE ZIPPER PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DISEASE EXACERBATION; GENE EXPRESSION; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ADENOVIRIDAE; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL PROLIFERATION; DEXAMETHASONE; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC THERAPY; GLUCOCORTICOIDS; HYPERSENSITIVITY, DELAYED; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC;

EID: 84876586387     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37858     Document Type: Article

References (43)

1. Saag KG, Koehnke R, Caldwell JR, Brasington R, Burmeister LF, Zimmerman B, et al. Low dose long-term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events. Am J Med 1994; 96: 115-23.
2. Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, Dreher R, et al. Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis 2009; 68: 1119-24.
3. Davis JM III, Maradit Kremers H, Crowson CS, Nicola PJ, Ballman KV, Therneau TM, et al. Glucocorticoids and cardiovascular events in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 2007; 56: 820-30.
4. Chinenov Y, Rogatsky I,. Glucocorticoids and the innate immune system: crosstalk with the Toll-like receptor signaling network. Mol Cell Endocrinol 2007; 275: 30-42.
5. Barnes PJ,. Glucocorticosteroids: current and future directions. Br J Pharmacol 2011; 163: 29-43.
6. D'Adamio F, Zollo O, Moraca R, Ayroldi E, Bruscoli S, Bartoli A, et al. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 1997; 7: 803-12.
7. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, et al. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB. Blood 2001; 98: 743-53.
8. Mittelstadt PR, Ashwell JD,. Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J Biol Chem 2001; 276: 29603-10.
9. Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C,. Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1. Mol Cell Biol 2002; 22: 7929-41.
10. Ayroldi E, Zollo O, Bastianelli A, Marchetti C, Agostini M, Di Virgilio R, et al. GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling. J Clin Invest 2007; 117: 1605-15.
11. Beaulieu E, Ngo D, Santos L, Yang YH, Smith M, Jorgensen C, et al. Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis. Arthritis Rheum 2010; 62: 2651-61.
12. Ayroldi E, Riccardi C,. Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action. FASEB J 2009; 23: 3649-58.
13. Beaulieu E, Morand EF,. Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis. Nat Rev Rheumatol 2011; 7: 340-8.
14. Bruscoli S, Velardi E, Di Sante M, Bereshchenko O, Venanzi A, Coppo M, et al. Long glucocorticoid-induced leucine zipper (L-GILZ) protein interacts with ras protein pathway and contributes to spermatogenesis control. J Biol Chem 2011; 287: 1242-51.
15. Kontgen F, Suss G, Stewart C, Steinmetz M, Bluethmann H,. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol 1993; 5: 957-64.
16. Ooi JD, Phoon RK, Holdsworth SR, Kitching AR,. IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J Am Soc Nephrol 2009; 20: 980-9.
17. Santos LL, Milenkovski GP, Hall PH, Leech M, Sharma L, Takeda K, et al. IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. Immunol Cell Biol 2006; 84: 166-73.
18. Santos LL, Fan H, Hall P, Ngo D, Mackay CR, Fingerle-Rowson G, et al. Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. Arthritis Rheum 2011; 63: 960-70.
19. Yamana J, Santos L, Morand E,. Enhanced induction of LPS-induced fibroblast MCP-1 by interferon-γ: involvement of JNK and MAPK phosphatase-1. Cell Immunol 2009; 255: 26-32.
20. Toh ML, Yang Y, Leech M, Santos L, Morand EF,. Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1β and glucocorticoids. Arthritis Rheum 2004; 50: 3118-28.
21. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
22. Yang YH, Aeberli D, Dacumos A, Xue JR, Morand EF,. Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipper. J Immunol 2009; 183: 1435-45.
23. Adriaansen J, Tas SW, Klarenbeek PL, Bakker AC, Apparailly F, Firestein GS, et al. Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy. Ann Rheum Dis 2005; 64: 1677-84.
24. Matsushita T, Elliger S, Elliger C, Podsakoff G, Villarreal L, Kurtzman GJ, et al. Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Ther 1998; 5: 938-45.
25. Cheng T, Pavlos NJ, Wang C, Tan JW, Lin JM, Cornish J, et al. Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation. Mol Endocrinol 2009; 23: 35-46.
26. Cannarile L, Cuzzocrea S, Santucci L, Agostini M, Mazzon E, Esposito E, et al. Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis. Gastroenterology 2009; 136: 530-41.
27. Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C,. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum 2010; 62: 1921-32.
28. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998; 93: 531-41.
29. Kleiman A, Hubner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, et al. Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J 2012; 26: 722-9.
30. Weinstein DS, Gong H, Doweyko AM, Cunningham M, Habte S, Wang JH, et al. Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation. J Med Chem 2011; 54: 7318-33.
31. Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato AC, et al. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 2006; 203: 15-20.
32. Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, et al. Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. Arthritis Rheum 2004; 50: 976-84.
33. Cannarile L, Fallarino F, Agostini M, Cuzzocrea S, Mazzon E, Vacca C, et al. Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines. Blood 2006; 107: 1039-47.
34. Liu XK, Lin X, Gaffen SL,. Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17. J Biol Chem 2004; 279: 52762-71.
35. Hamdi H, Bigorgne Al, Naveau S, Balian A, Bouchet-Delbos L, Cassard-Doulcier AM, et al. Glucocorticoid-induced leucine zipper: a key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis. Hepatology 2007; 46: 1986-92.
36. Yang N, Zhang W, Shi XM,. Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression. J Cell Biochem 2008; 103: 1760-71.
37. Esposito E, Bruscoli S, Mazzon E, Paterniti I, Coppo M, Velardi E, et al. Glucocorticoid-induced leucine zipper (GILZ) over-expression in T lymphocytes inhibits inflammation and tissue damage in spinal cord injury. Neurotherapeutics 2011; 9: 210-25.
38. Adriaansen J, Vervoordeldonk MJ, Tak PP,. Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes. Rheumatology (Oxford) 2006; 45: 656-68.
39. Xin KQ, Mizukami H, Urabe M, Toda Y, Shinoda K, Yoshida A, et al. Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. J Virol 2006; 80: 11899-910.
40. He L, Yang N, Isales CM, Shi XM,. Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation. PloS One 2012; 7: e31717.
41. Campbell IK, Hamilton JA, Wicks IP,. Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 2000; 30: 1568-75.
42. Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 2011; 145: 224-41.
43. Leech M, Metz C, Bucala R, Morand EF,. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. Arthritis Rheum 2000; 43: 827-33.