Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Sekigawa, Akio ^a   Takamatsu, Yoshiki ^a   Sekiyama, Kazunari ^a   Takenouchi, Takato ^b   Sugama, Shuei ^c   Waragai, Masaaki ^a   Fujita, Masayo ^a   Hashimoto, Makoto ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE-RICH REPEATS; LEWY BODIES; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; MOUSE MODELS; PARKINSON'S DISEASE; SYNUCLEIN; TRANSGENIC MICE;

AMINO ACIDS; CELL CULTURE; ENZYMES; MAMMALS; MITOCHONDRIA; NEURODEGENERATIVE DISEASES;

PATHOLOGY;

ALPHA SYNUCLEIN; ALPHA TOCOPHEROL; ANTIOXIDANT; LEUCINE RICH REPEAT KINASE 2; PARKIN; PROTEIN KINASE; PTEN INDUCED KINASE 1; UNCLASSIFIED DRUG; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE; SYNUCLEIN;

BRAIN DISEASE; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; LEWY BODY; MOLECULAR PATHOLOGY; NERVE FIBER DEGENERATION; NEUROPATHY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SYNUCLEINOPATHY; ANIMAL; DEMENTIA; DIFFUSE LEWY BODY DISEASE; DISEASE MODEL; METABOLISM; MITOCHONDRION; NERVE FIBER; PATHOLOGY;

MUS; MUS MUSCULUS;

ANIMALS; AXONS; DEMENTIA; DISEASE MODELS, ANIMAL; LEWY BODY DISEASE; MITOCHONDRIA; PARKINSON DISEASE; PROTEIN KINASES; SYNUCLEINS;

EID: 84876584556     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/817807     Document Type: Review

References (35)

1. Esteves A. R., Arduíno D. M., Silva D. F. F., Oliveira C. R., Cardoso S. M., Mitochondrial dysfunction: the road to alpha-synuclein oligomerization in PD. Parkinson's Disease 2011 2011 20 2-s2.0-79952169319 10.4061/2011/693761 693761
2. Exner N., Lutz A. K., Haass C., Winklhofer K. F., Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. The EMBO Journal 2012 31 3038 3062
3. Hashimoto M., Rockenstein E., Crews L., Masliah E., Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases. NeuroMolecular Medicine 2003 4 1-2 21 35 2-s2.0-0142200947 10.1385/NMM:4:1-2:21 (Pubitemid 37315183)
4. Langston J. W., The etiology of Parkinson's disease with emphasis on the MPTP story. Neurology 1996 47 6, supplement 3 S153 S160 2-s2.0-0029751103 (Pubitemid 26422581)
5. Schapira A. H. V., Cooper J. M., Dexter D., Jenner P., Clark J. B., Marsden C. D., Mitochondrial complex I deficiency in Parkinson's disease. The Lancet 1989 1 8649 1269 2-s2.0-0024390719 (Pubitemid 19140359)
6. Bender A., Krishnan K. J., Morris C. M., Taylor G. A., Reeve A. K., Perry R. H., Jaros E., Hersheson J. S., Betts J., Klopstock T., Taylor R. W., Turnbull D. M., High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nature Genetics 2006 38 5 515 517 2-s2.0-33646375711 10.1038/ng1769
7. Mizuno Y., Hattori N., Mochizuki H., Genetic aspects of Parkinson's disease. Handbook of Clinical Neurology 2007 83 217 244 2-s2.0-67649308674 10.1016/S0072-9752(07)83009-0
8. Sekigawa A., Fujita M., Sekiyama K., Distinct mechanisms of axonal globule formation in mice expressing human wild type alpha-synuclein or dementia with Lewy bodies-linked P123H beta-synuclein. Molecular Brain 2012 5, article 34
9. Bonifati V., Rizzu P., van Baren M. J., Schaap O., Breedveld G. J., Krieger E., Dekker M. C. J., Squitieri F., Ibanez P., Joosse M., Van Dongen J. W., Vanacore N., Van Swieten J. C., Brice A., Meco G., Van Duijn C. M., Oostra B. A., Heutink P., Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003 299 5604 256 259 2-s2.0-0037428241 10.1126/science.1077209 (Pubitemid 36131051)
10. Valente E. M., Abou-Sleiman P. M., Caputo V., Muqit M. M. K., Harvey K., Gispert S., Ali Z., Del Turco D., Bentivoglio A. R., Healy D. G., Albanese A., Nussbaum R., González-Maldonado R., Deller T., Salvi S., Cortelli P., Gilks W. P., Latchman D. S., Harvey R. J., Dallapiccola B., Auburger G., Wood N. W., Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004 304 5674 1158 1160 2-s2.0-2442668926 10.1126/science.1096284 (Pubitemid 38661852)
11. Okatsu K., Oka T., Iguchi M., PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nature Communications 2012 3, article 1016
12. Tan J. M. M., Dawson T. M., Parkin blushed by PINK1. Neuron 2006 50 4 527 529 2-s2.0-33646434793 10.1016/j.neuron.2006.05.003
13. Youle R. J., Narendra D. P., Mechanisms of mitophagy. Nature Reviews Molecular Cell Biology 2011 12 9 14
14. Arduino D. M., Esteves A. R., Cortes L., Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic. Human Molecular Genetics 2012 21 4680 4702
15. Hsu L. J., Sagara Y., Arroyo A., Rockenstein E., Sisk A., Mallory M., Wong J., Takenouchi T., Hashimoto M., Masliah E., α -Synuclein promotes mitochondrial deficit and oxidative stress. American Journal of Pathology 2000 157 2 401 410 2-s2.0-0033890821 (Pubitemid 30627559)
16. Nakamura K., Nemani V. M., Azarbal F., Skibinski G., Levy J. M., Egami K., Munishkina L., Zhang J., Gardner B., Wakabayashi J., Sesaki H., Cheng Y., Finkbeiner S., Nussbaum R. L., Masliah E., Edwards R. H., Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein α -synuclein. The Journal of Biological Chemistry 2011 286 23 20710 20726 2-s2.0-79957974579 10.1074/jbc.M110.213538
17. Paisán-Ruíz C., Jain S., Evans E. W., Gilks W. P., Simón J., Van Der Brug M., De Munain A. L., Aparicio S., Gil A. M., Khan N., Johnson J., Martinez J. R., Nicholl D., Carrera I. M., Peňa A. S., De Silva R., Lees A., Martí-Massó J. F., Pérez-Tur J., Wood N. W., Singleton A. B., Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004 44 4 595 600 2-s2.0-8844266996 10.1016/j.neuron.2004.10.023 (Pubitemid 39531224)
18. Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., Kachergus J., Hulihan M., Uitti R. J., Calne D. B., Stoessl A. J., Pfeiffer R. F., Patenge N., Carbajal I. C., Vieregge P., Asmus F., Müller-Myhsok B., Dickson D. W., Meitinger T., Strom T. M., Wszolek Z. K., Gasser T., Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004 44 4 601 607 2-s2.0-8844233579 10.1016/j.neuron.2004.11.005 (Pubitemid 39531225)
19. Cookson M. R., The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nature Reviews Neuroscience 2010 11 12 791 797 2-s2.0-78649389313 10.1038/nrn2935
20. Biskup S., Moore D. J., Celsi F., Higashi S., West A. B., Andrabi S. A., Kurkinen K., Yu S. W., Savitt J. M., Waldvogel H. J., Faull R. L. M., Emson P. C., Torp R., Ottersen O. P., Dawson T. M., Dawson V. L., Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Annals of Neurology 2006 60 5 557 569 2-s2.0-33845298032 10.1002/ana.21019 (Pubitemid 44871798)
21. Wang X., Yan M. H., Fujioka H., LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Human Molecular Genetics 2012 21 1931 1944
22. Poulopoulos M., Levy O. A., Alcalay R. N., The neuropathology of genetic Parkinson's disease. Movement Disorders 2012 27 831 842
23. Seitelberger F., Neuropathological conditions related to neuroaxonal dystrophy. Acta Neuropathologica 1971 5 supplement 5 17 29 2-s2.0-0014994728
24. Fujita M., Sugama S., Sekiyama K., Sekigawa A., Tsukui T., Nakai M., Waragai M., Takenouchi T., Takamatsu Y., Wei J., Rockenstein E., Laspada A. R., Masliah E., Inoue S., Hashimoto M., A β -synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nature Communications 2010 1 8, article 110 2-s2.0-78650066331 10.1038/ncomms1101
25. MacLeod D., Dowman J., Hammond R., Leete T., Inoue K., Abeliovich A., The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 2006 52 4 587 593 2-s2.0-33751256567 10.1016/j.neuron.2006.10.008 (Pubitemid 44781171)
26. Li Y., Liu W., Oo T. F., Wang L., Tang Y., Jackson-Lewis V., Zhou C., Geghman K., Bogdanov M., Przedborski S., Beal M. F., Burke R. E., Li C., Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience 2009 12 7 826 828 2-s2.0-67649813448 10.1038/nn.2349
27. Lee M. K., Stirling W., Xu Y., Xu E., Qui D., Mandir A. S., Dawson T. M., Copeland N. G., Jenkins N. A., Price D. L., Human α -synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α -synuclein aggregation in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 2002 99 13 8968 8973 2-s2.0-0037173006 10.1073/pnas.132197599 (Pubitemid 34693667)
28. Ohtake H., Limprasert P., Fan Y., Onodera O., Kakita A., Takahashi H., Bonner L. T., Tsuang D. W., Murray I. V. J., Lee V. M. Y., Trojanowski J. Q., Ishikawa A., Idezuka J., Murata M., Toda T., Bird T. D., Leverenz J. B., Tsuji S., La Spada A. R., β -synuclein gene alterations in dementia with Lewy bodies. Neurology 2004 63 5 805 811 2-s2.0-4644359042 (Pubitemid 39297638)
29. Hashimoto M., La Spada A. R., β -synuclein in the pathogenesis of Parkinson's disease and related α -synucleinopathies: emerging roles and new directions. Future Neurology 2012 7 155 163
30. Fujita M., Sekigawa A., Sekiyama K., Takamatsu Y., Hashimoto M., Possible alterations in beta-synuclein, the non-amyloidogenic homologue of alpha-synuclein, during progression of sporadic alpha-synucleinopathies. International Journal of Molecular Sciences 2012 13 11584 11592
31. Galvin J. E., Uryu K., Lee V. M. Y., Trojanowski J. Q., Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains α -, β -, and γ -synuclein. Proceedings of the National Academy of Sciences of the United States of America 1999 96 23 13450 13455 2-s2.0-0033539664
32. -synuclein neuropathology. American Journal of Pathology 2000 157 2 361 368 2-s2.0-0033897735 (Pubitemid 30626903)
33. -synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse. Brain Research 2004 1019 1-2 1 9 2-s2.0-4043089794 10.1016/j.brainres.2004.05.023 (Pubitemid 39078604)
34. Tatsioni A., Bonitsis N. G., Ioannidis J. P. A., Persistence of contradicted claims in the literature. Journal of the American Medical Association 2007 298 21 2517 2526 2-s2.0-36849073200 10.1001/jama.298.21.2517 (Pubitemid 350223538)
35. Petersen R. C., Thomas R. G., Grundman M., Bennett D., Doody R., Ferris S., Galasko D., Jin S., Kaye J., Levey A., Pfeiffer E., Sano M., Van Dyck C. H., Thal L. J., Vitamin E and donepezil for the treatment of mild cognitive impairment. The New England Journal of Medicine 2005 352 23 2379 2388 2-s2.0-20344381835 10.1056/NEJMoa050151