Intestinal epithelial restitution after TcdB challenge and recovery from clostridium difficile infection in mice with alanyl-glutamine treatment

Journal of Infectious Diseases

Volumn 207, Issue 10, 2013, Pages 1505-1515

  Rodrigues, Raphael S ^a   Oliveira, Renato A C ^a   Li, Yuesheng ^b   Zaja Milatovic, Snjezana ^b   Costa, Lourrany B ^a   Braga Neto, Manuel B ^a   Kolling, Glynis L ^b   Lima, Aldo A ^a   Guerrant, Richard L ^b   Warren, Cirle Alcantara ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

alanyl glutamine; C. difficile; diarrhea

Indexed keywords

ALANYLGLUTAMINE; CLINDAMYCIN; CLOSTRIDIUM DIFFICILE TOXIN B; COLISTIN; GENTAMICIN; METRONIDAZOLE; MYELOPEROXIDASE; VANCOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL ASSAY; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN IEC 6; CELL STRAIN WST 1; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL; TREATMENT RESPONSE;

ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; CELL PROLIFERATION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DIPEPTIDES; DISEASE MODELS, ANIMAL; ENTEROCYTES; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; NECROSIS; RATS; VANCOMYCIN;

EID: 84876584059     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit041     Document Type: Article

References (38)

1. Dubberke ER, Wertheimer AI. Review of current literature on the economic burden of Clostridium difficile infection. Infect Control Hosp Epidemiol 2009; 30:57-66.
2. Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 2009; 7:526-36.
3. Wilcox MH, Mooney L, Bendall R, Settle CD, Fawley WN. A casecontrol study of community-associated Clostridium difficile infection. J Antimicrob Chemother 2008; 62:388-96. (Pubitemid 351984787)
4. Voth DE, Ballard JD. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 2005; 18:247-63. (Pubitemid 40548293)
5. Jank T, Aktories K. Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol 2008; 16:222-9.
6. Nusrat A, von Eichel-Streiber C, Turner JR, Verkade P, Madara JL, Parkos CA. Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins. Infect Immun 2001; 69:1329-36. (Pubitemid 32187577)
7. Brito GA, Fujji J, Carneiro-Filho BA, Lima AA, Obrig T, Guerrant RL. Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells. J Infect Dis 2002; 186:1438-47. (Pubitemid 35286111)
8. Carneiro BA, Fujii J, Brito GA, et al. Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro. Infect Immun 2006; 74:81-7. (Pubitemid 43023061)
9. Fiorentini C, Fabbri A, Falzano L, et al. Clostridium difficile toxin B induces apoptosis in intestinal cultured cells. Infect Immun 1998; 66:2660-5. (Pubitemid 28261767)
10. Qa'Dan M, Ramsey M, Daniel J, et al. Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells. Cell Microbiol 2002; 4:425-34. (Pubitemid 34830925)
11. Schwan C, Stecher B, Tzivelekidis T, et al. Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog 2009; 5:e1000626.
12. Reeds PJ, Burrin DG. Glutamine and the bowel. J Nutr 2001; 131:2505S-8. ; discussion 23S-4S.
13. Ziegler TR, Bazargan N, Leader LM, Martindale RG. Glutamine and the gastrointestinal tract. Curr Opin Clin Nutr Metab Care 2000; 3:355-62.
14. Brito GA, Carneiro-Filho B, Oria RB, Destura RV, Lima AA, Guerrant RL. Clostridium difficile toxin A induces intestinal epithelial cell apoptosis and damage: role of Gln and Ala-Gln in toxin A effects. Dig Dis Sci 2005; 50:1271-8. (Pubitemid 41184754)
15. McCormack SA, Viar MJ, Johnson LR. Migration of IEC-6 cells: a model for mucosal healing. Am J Physiol 1992; 263:G426-35.
16. Chen X, Katchar K, Goldsmith JD, et al. A mouse model of Clostridium difficile infection. Gastroenterology 2008; 135:1984-92.
17. Warren CA, van Opstal E, Ballard TE, et al. Amixicile: A novel inhibitor of pyruvate: ferredoxin oxidoreductase shows efficacy against Clostridium difficile in a mouse infection model. Antimicrob Agents Chemother 2012; 56:4103-11.
18. Pawlowski SW, Calabrese G, Kolling GL, et al. Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strain. J Infect Dis 2010; 202:1708-12.
19. Warren CA, Calabrese GM, Li Y, et al. Effects of adenosine A(2)A receptor activation and alanyl-glutamine in Clostridium difficile toxininduced ileitis in rabbits and cecitis in mice. BMC Infect Dis 2012; 12:13.
20. Wang JY, Johnson LR. Induction of gastric and duodenal mucosal ornithine decarboxylase during stress. Am J Physiol 1989; 257:G259-65.
21. Silen W. Gastric mucosal defense and repair. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1987:1055-69.
22. Santos MF, McCormack SA, Guo Z, et al. Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest 1997; 100:216-25. (Pubitemid 27311260)
23. Gerhard R, Nottrott S, Schoentaube J, Tatge H, Olling A, Just I. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells. J Med Microbiol 2008; 57: 765-70. (Pubitemid 351842070)
24. Fürst P, Albers S, Stehle P. Availability of glutamine supplied intravenously as alanylglutamine. Metabolism 1989; 38(8 Suppl 1):67-72. (Pubitemid 19207467)
25. Carneiro-Filho BA, Bushen OY, Brito GA, Lima AA, Guerrant RL. Glutamine Analogues As Adjunctive Therapy for Infectious Diarrhea. Curr Infect Dis Rep 2003; 5:114-9. (Pubitemid 38899167)
26. Tazuke Y, Maeda K, Wasa M, Satoko N, Fukuzawa M. Protective mechanism of glutamine on the expression of proliferating cell nuclear antigen after cisplatin-induced intestinal mucosal injury. Pediatr Surg Int 2011; 27:151-8.
27. Braga-Neto MB, Warren CA, Oria RB, et al. Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro. Dig Dis Sci 2008; 53:2687-96.
28. Larson SD, Li J, Chung DH, Evers BM. Molecular mechanisms contributing to glutamine-mediated intestinal cell survival. Am J Physiol Gastrointest Liver Physiol 2007; 293:G1262-71. (Pubitemid 350255039)
29. Sun X, Wang H, Zhang Y, Chen K, Davis B, Feng H. Mouse relapse model of Clostridium difficile infection. Infect Immun 2011; 79: 2856-64.
30. Edlund C, Barkholt L, Olsson-Liljequist B, Nord CE. Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy. Clin Infect Dis 1997; 25:729-32. (Pubitemid 27392620)
31. Baines SD, O'Connor R, Saxton K, Freeman J, Wilcox MH. Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother 2009; 63:520-5.
32. Wilmore DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr 2001; 131: 2543S-9; discussion 50S-1S.
33. Ziegler TR, Ogden LG, Singleton KD, et al. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 2005; 31:1079-86. (Pubitemid 41125339)
34. Nascimento SB, Sousa RB, Martins MJ, et al. Glutamine depletion potentiates leucocyte-dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats. Immunology 2005; 116:328-36. (Pubitemid 41532124)
35. Lima AA, Carvalho GH, Figueiredo AA, et al. Effects of an alanylglutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. Nutrition 2002; 18:458-62. (Pubitemid 34586800)
36. Silva AC, Santos-Neto MS, Soares AM, Fonteles MC, Guerrant RL, Lima AA. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr 1998; 26:513-9. (Pubitemid 28183601)
37. Fang A, Gerson DF, Demain AL. Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests. Proc Natl Acad Sci USA 2009; 106:13225-9.
38. O'Keefe SJ. Tube feeding, the microbiota, and Clostridium difficile infection. World J Gastroenterol 2010; 16:139-42.