Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2

Biological Chemistry

Volumn 393, Issue 6, 2012, Pages 473-484

  Esterházy, Daria ^a   Akpinar, Pinar ^b,d   Stoffel, Markus ^a,b,c  

^a ETH ZURICH   (Switzerland)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d PriceSpective   (United Kingdom)

Author keywords

ectodomain cleavage; MIN6; pancreatic cell; protease inhibitor

Indexed keywords

ASPARAGINE; BETA SECRETASE 2; CELL SURFACE PROTEIN; CYSTEINE; GLUCOSE; PHENYLALANINE; PROTEIN TMEM27; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DEGLYCOSYLATION; DIMERIZATION; ENZYME INHIBITION; ENZYME SUBSTRATE; GLYCOSYLATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TRANSPORT; WESTERN BLOTTING;

AMINO ACID MOTIFS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; EXTRACELLULAR SPACE; GLUCOSE; GLYCOSYLATION; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MUTATION; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT;

EID: 84861388554     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0104     Document Type: Article

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