Generation and characterization of fully human monoclonal antibodies against human orai1 for autoimmune diseases

Journal of Pharmacology and Experimental Therapeutics

Volumn 345, Issue 2, 2013, Pages 225-238

  Lin, Fen Fen ^a   Elliott, Robin ^a   Colombero, Anne ^a   Gaida, Kevin ^a   Kelley, Laura ^a   Moksa, Angelica ^a   Ho, Shu Yin ^a   Bykova, Ekaterina ^a   Wong, Min ^a   Rathanaswami, Palaniswami ^a   Hu, Sylvia ^a   Sullivan, John K ^a   Nguyen, Hung Q ^a   McBride, Helen J ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; MONOCLONAL ANTIBODY; STROMAL INTERACTION MOLECULE 1; TRANSCRIPTION FACTOR NFAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; EPITOPE MAPPING; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNOREACTIVITY; MULTIPLE SCLEROSIS; ORGAN TRANSPLANTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RHEUMATOID ARTHRITIS; SEVERE COMBINED IMMUNODEFICIENCY; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION;

AEQUORIN; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; BLOTTING, WESTERN; CALCIUM CHANNELS; CHIMERA; CYTOKINES; EPITOPE MAPPING; EPITOPES; FLOW CYTOMETRY; GENES, REPORTER; HEK293 CELLS; HUMANS; JURKAT CELLS; KINETICS; LUCIFERASES; MICE; MOLECULAR SEQUENCE DATA; NFATC TRANSCRIPTION FACTORS; PATCH-CLAMP TECHNIQUES; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS;

EID: 84876524918     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.202788     Document Type: Article

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