The role of PPARs in placental immunology: A systematic review of the literature

PPAR Research

Volumn , Issue , 2013, Pages

  Hutter, Stefan ^a   Knabl, Julia ^a   Andergassen, Ulrich ^a   Jeschke, Udo ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

B LYMPHOCYTE; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MACROPHAGE; META ANALYSIS; NATURAL KILLER CELL; NONHUMAN; PLACENTA; REPRODUCTION; REVIEW; SYSTEMATIC REVIEW; T LYMPHOCYTE; TH1 TH2 BALANCE;

EID: 84876524352     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2013/970276     Document Type: Review

References (84)

1. Renaud S. J., Postovit L. M., Macdonald-Goodfellow S. K., McDonald G. T., Caldwell J. D., Graham C. H., Activated macrophages inhibit human cytotrophoblast invasiveness in vitro. Biology of Reproduction 2005 73 2 237 243 2-s2.0-22544471215 10.1095/biolreprod.104.038000 (Pubitemid 41022782)
2. Reister F., Frank H. G., Kingdom J. C. P., Heyl W., Kaufmann P., Rath W., Huppertz B., Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women. Laboratory Investigation 2001 81 8 1143 1152 2-s2.0-0034883831 (Pubitemid 32772074)
3. Hiby S. E., Walker J. J., O'Shaughnessy K. M., Redman C. W. G., Carrington M., Trowsdale J., Moffett A., Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. Journal of Experimental Medicine 2004 200 8 957 965 2-s2.0-7244234068 10.1084/jem.20041214 (Pubitemid 39431121)
4. Williams P. J., Bulmer J. N., Searle R. F., Innes B. A., Robson S. C., Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy. Reproduction 2009 138 1 177 184 2-s2.0-70449380590 10.1530/REP-09-0007
5. Wegmann T. G., Lin H., Guilbert L., Mosmann T. R., Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunology Today 1993 14 7 353 356 2-s2.0-0027207375 (Pubitemid 23198169)
6. McCracken S. A., Gallery E., Morris J. M., Pregnancy-specific down-regulation of NF-kappa B expression in T cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success. The Journal of Immunology 2004 172 7 4583 4591 2-s2.0-1642334209 (Pubitemid 38375276)
7. + CD25 bright regulatory T cells in pre-eclampsia. Clinical and Experimental Immunology 2007 149 1 139 145 2-s2.0-34250182084 10.1111/j.1365-2249.2007.03397.x (Pubitemid 46897107)
8. + CD25 bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. The Journal of Immunology 2008 180 8 5737 5745 2-s2.0-45949107443
9. Guenther S., Vrekoussis T., Heublein S., Bayer B., Anz D., Knabl J., Navrozoglou I., Dian D., Friese K., Makrigiannakis A., Jeschke: U., Decidual macrophages are significantly increased in spontaneous miscarriages and over-express fasL: a potential role for macrophages in trophoblast apoptosis. International Journal of Molecular Sciences 2012 13 7 9069 9080
10. Semple R. K., Chatterjee V. K. K., O'Rahilly S., PPAR γ and human metabolic disease. The Journal of Clinical Investigation 2006 116 3 581 589 2-s2.0-33644644599 10.1172/JCI28003 (Pubitemid 43326862)
11. Yu S., Reddy J. K., Transcription coactivators for peroxisome proliferator-activated receptors. Biochimica et Biophysica Acta 2007 1771 8 936 951 2-s2.0-34547604561 10.1016/j.bbalip.2007.01.008 (Pubitemid 47198542)
12. Beaven S. W., Tontonoz P., Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annual Review of Medicine 2006 57 313 329 2-s2.0-32944473282 10.1146/annurev.med.57.121304.131428 (Pubitemid 43261994)
13. Chinetti G., Fruchart J. C., Staels B., Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflammation Research 2000 49 10 497 505 2-s2.0-0033793133 10.1007/s000110050622
14. Standiford T. J., Keshamouni V. G., Reddy R. C., Peroxisome proliferator-activated receptor-{gamma} as a regulator of lung inflammation and repair. Proceedings of the American Thoracic Society 2005 2 226 231 (Pubitemid 41500850)
15. Michalik L., Desvergne B., Dreyer C., Gavillet M., Laurini R. N., Wahli W., PPAR expression and function during vertebrate development. International Journal of Developmental Biology 2002 46 1 105 114 2-s2.0-0036005782 (Pubitemid 34226309)
16. Lappas M., Rice G. E., Transcriptional regulation of the processes of human labour and delivery. Placenta 2009 30 supplement 90 95 2-s2.0-60549107016 10.1016/j.placenta.2008.10.005
17. Holdsworth-Carson S. J., Lim R., Mitton A., Whitehead C., Rice G. E., Permezel M., Lappas M., Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia. Placenta 2010 31 3 222 229 2-s2.0-77049111523 10.1016/j.placenta.2009.12.009
18. Tarrade A., Schoonjans K., Pavan L., Auwerx J., Rochette-Egly C., Evain-Brion D., Fournier T., PPAR γ /RXR α heterodimers control human trophoblast invasion. Journal of Clinical Endocrinology and Metabolism 2001 86 10 5017 5024 2-s2.0-0034740085 10.1210/jc.86.10.5017 (Pubitemid 33020558)
19. Martínez N., Kurtz M., Capobianco E., Higa R., White V., Jawerbaum A., PPAR α agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats. Journal of Molecular Endocrinology 2011 47 1 1 12 2-s2.0-79960999898 10.1530/JME-10-0173
20. Wang H., Xie H., Sun X., Tranguch S., Zhang H., Jia X., Wang D., Das S. K., Desvergne B., Wahli W., Dubois R. N., Dey S. K., Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor δ signaling is critical to pregnancy success. The Journal of Biological Chemistry 2007 282 52 37770 37782 2-s2.0-38049115662 10.1074/jbc.M706577200
21. Tarrade A., Schoonjans K., Pavan L., Auwerx J., Rochette-Egly C., Evain-Brion D., Fournier T., PPAR γ /RXR α heterodimers control human trophoblast invasion. Journal of Clinical Endocrinology and Metabolism 2001 86 10 5017 5024 2-s2.0-0034740085 10.1210/jc.86.10.5017 (Pubitemid 33020558)
22. Rauwel B., Mariamé B., Martin H., Nielsen R., Allart S., Pipy B., Mandrup S., Devignes M. D., Evain-Brion D., Fournier T., Davrinche C., Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for De Novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas. Journal of Virology 2010 84 6 2946 2954 2-s2.0-77649120022 10.1128/JVI.01779-09
23. Belfort R., Berria R., Cornell J., Cusi K., Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2010 95 2 829 836 2-s2.0-76149092815 10.1210/jc.2009-1487
24. Lefebvre P., Chinetti G., Fruchart J. C., Staels B., Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. The Journal of Clinical Investigation 2006 116 571 580 10.1172/ JCI27989 (Pubitemid 43326861)
25. Wang Q., Fujii H., Knipp G. T., Expression of PPAR and RXR isoforms in the developing rat and human term placentas. Placenta 2002 23 8-9 661 671 2-s2.0-0036730903 10.1053/plac.2002.0855 (Pubitemid 37184675)
26. Martínez N., Kurtz M., Capobianco E., Higa R., White V., Jawerbaum A., PPAR α agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats. Journal of Molecular Endocrinology 2011 47 1 1 12 2-s2.0-79960999898 10.1530/JME-10-0173
27. Mikael L. G., Pancer J., Wu Q., Rozen R., Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPAR α interferon- γ and interleukin-10. Journal of Nutrition 2012 142 3 411 418
28. Yessoufou A., Hichami A., Besnard P., Moutairou K., Khan N. A., Peroxisome proliferator-activated receptor α deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: modulation of T cell differentiation. Endocrinology 2006 147 9 4410 4418 2-s2.0-33747598715 10.1210/en.2006-0067 (Pubitemid 44268392)
29. Mukherjee R., Jow L., Croston G. E., Paterniti J. R., Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPAR γ 2 versus PPAR γ 1 and activation with retinoid X receptor agonists and antagonists. The Journal of Biological Chemistry 1997 272 12 8071 8076 2-s2.0-0030951143 10.1074/jbc.272.12.8071 (Pubitemid 27137374)
30. Wang H., Xie H., Sun X., Tranguch S., Zhang H., Jia X., Wang D., Das S. K., Desvergne B., Wahli W., Dubois R. N., Dey S. K., Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor δ signaling is critical to pregnancy success. The Journal of Biological Chemistry 2007 282 52 37770 37782 2-s2.0-38049115662 10.1074/jbc.M706577200
31. Barak Y., Liao D., He W., Ong E. S., Nelson M. C., Olefsky J. M., Boland R., Evans R. M., Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America 2002 99 1 303 308 2-s2.0-0037039374 10.1073/pnas.012610299 (Pubitemid 34060358)
32. Julan L., Guan H., Van Beek J. P., Yang K., Peroxisome proliferator-activated receptor δ suppresses 11 β -hydroxysteroid dehydrogenase type 2 gene expression in human placental trophoblast cells. Endocrinology 2005 146 3 1482 1490 2-s2.0-14244261749 10.1210/en.2004-1357 (Pubitemid 40289338)
33. Dunn S. E., Bhat R., Straus D. S., Sobel R. A., Axtell R., Johnson A., Nguyen K., Mukundan L., Moshkova M., Dugas J. C., Chawla A., Steinman L., Peroxisome proliferator-activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity. Journal of Experimental Medicine 2010 207 8 1599 1608 2-s2.0-77955343205 10.1084/jem.20091663
34. Toth B., Bastug M., Scholz C., Arck P., Schulze S., Kunze S., Friese K., Jeschke U., Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Histology and Histopathology 2008 23 12 1465 1475 2-s2.0-58149299728
35. Schaiff W. T., Knapp F. F., Barak Y., Biron-Shental T., Nelson D. M., Sadovsky Y., Ligand-activated peroxisome proliferator activated receptor γ alters placental morphology and placental fatty acid uptake in mice. Endocrinology 2007 148 8 3625 3634 2-s2.0-34547121969 10.1210/en.2007-0211 (Pubitemid 47105868)
36. Tarrade A., Schoonjans K., Pavan L., Auwerx J., Rochette-Egly C., Evain-Brion D., Fournier T., PPAR γ /RXR α heterodimers control human trophoblast invasion. Journal of Clinical Endocrinology and Metabolism 2001 86 10 5017 5024 2-s2.0-0034740085 10.1210/jc.86.10.5017 (Pubitemid 33020558)
37. McCarthy F. P., Drewlo S., Kingdom J., Johns E. J., Walsh S. K., Kenny L. C., Peroxisome proliferator-activated receptor- γ as a potential therapeutic target in the treatment of preeclampsia. Hypertension 2011 58 2 280 286 2-s2.0-80051471606 10.1161/HYPERTENSIONAHA.111.172627
38. Street M. E., Seghini P., Feini S., Ziveri M. A., Volta C., Martorana D., Viani I., Gramellini D., Bernasconi S., Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls. European Journal of Endocrinology 2006 155 4 567 574 2-s2.0-33750232507 10.1530/eje.1.02251 (Pubitemid 44608430)
39. Desai M., Guang Han, Ferelli M., Kallichanda N., Lane R. H., Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Reproductive Sciences 2008 15 8 785 796 2-s2.0-54349128127 10.1177/1933719108318597
40. Schaiff W. T., Bildirici I., Cheong M., Chern P. L., Nelson D. M., Sadovsky Y., Peroxisome proliferator-activated receptor- γ and retinoid X receptor signaling regulate fatty acid uptake by primary human placental Trophoblasts. Journal of Clinical Endocrinology and Metabolism 2005 90 7 4267 4275 2-s2.0-23044498079 10.1210/jc.2004-2265 (Pubitemid 41058208)
41. McCarthy F. P., Drewlo S., English F. A., Kingdom J., Johns E. J., Kenny L. C., Walsh S. K., Evidence implicating peroxisome proliferator-activated receptor- γ in the pathogenesis of preeclampsia. Hypertension 2011 58 5 882 887
42. Lappas M., Permezel M., Georgiou H. M., Rice G. E., Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor- γ: effect of 15-deoxy- δ 12,14-PGJ2 and troglitazone. Journal of Clinical Endocrinology and Metabolism 2002 87 10 4667 4672 2-s2.0-0036774446 10.1210/jc.2002-020613 (Pubitemid 35247059)
43. Vats D., Mukundan L., Odegaard J. I., Zhang L., Smith K. L., Morel C. R., Greaves D. R., Murray P. J., Chawla A., Oxidative metabolism and PGC-1 β attenuate macrophage-mediated inflammation. Cell Metabolism 2006 4 1 13 24 2-s2.0-33745428666 10.1016/j.cmet.2006.05.011 (Pubitemid 43942258)
44. Odegaard J. I., Ricardo-Gonzalez R. R., Goforth M. H., Morel C. R., Subramanian V., Mukundan L., Eagle A. R., Vats D., Brombacher F., Ferrante A. W., Chawla A., Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance. Nature 2007 447 7148 1116 1120 2-s2.0-34347354309 10.1038/nature05894 (Pubitemid 47014427)
45. Nagamatsu T., Schust D. J., The contribution of macrophages to normal and pathological pregnancies. American Journal of Reproductive Immunology 2010 63 6 460 471 2-s2.0-77953946507 10.1111/j.1600-0897.2010.00813.x
46. Porcheray F., Viaud S., Rimaniol A. C., Léone C., Samah B., Dereuddre-Bosquet N., Dormont D., Gras G., Macrophage activation switching: an asset for the resolution of inflammation. Clinical and Experimental Immunology 2005 142 3 481 489 2-s2.0-28344449833 10.1111/j.1365-2249.2005.02934.x (Pubitemid 41719844)
47. Martinez F. O., Helming L., Gordon S., Alternative activation of macrophages: an immunologic functional perspective. Annual Review of Immunology 2009 27 451 483 2-s2.0-67650485985 10.1146/annurev.immunol.021908.132532
48. Ricote M., Welch J. S., Glass C. K., Regulation of macrophage gene expression by the peroxisome proliferator-activated receptor- γ Hormone Research 2000 54 5-6 275 280 2-s2.0-0034583170 10.1159/000053271 (Pubitemid 34701733)
49. Chawla A., Control of macrophage activation and function by PPARs. Circulation Research 2010 106 10 1559 1569 2-s2.0-77952997178 10.1161/CIRCRESAHA.110.216523
50. Bouhlel M. A., Derudas B., Rigamonti E., Dièvart R., Brozek J., Haulon S., Zawadzki C., Jude B., Torpier G., Marx N., Staels B., Chinetti-Gbaguidi G., PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metabolism 2007 6 2 137 143 2-s2.0-34547492488 10.1016/j.cmet.2007.06.010 (Pubitemid 47189091)
51. Chinetti G., Fruchart J. C., Staels B., Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function. Current Opinion in Lipidology 2003 14 5 459 468 2-s2.0-0142093152 10.1097/00041433-200310000-00006 (Pubitemid 37297300)
52. Sica A., Mantovani A., Macrophage plasticity and polarization: in vivo veritas. The Journal of Clinical Investigation 2012 122 3 787 795
53. Mukundan L., Odegaard J. I., Morel C. R., Heredia J. E., Mwangi J. W., Ricardo-Gonzalez R. R., Goh Y. P. S., Eagle A. R., Dunn S. E., Awakuni J. U. H., Nguyen K. D., Steinman L., Michie S. A., Chawla A., PPAR-Δ senses and orchestrates clearance of apoptotic cells to promote tolerance. Nature Medicine 2009 15 11 1266 1272 2-s2.0-70449094641 10.1038/nm.2048
54. Dong M., He J., Wang Z., Xie X., Wang H., Placental imbalance of Th1- and Th2-type cytokines in preeclampsia. Acta Obstetricia et Gynecologica Scandinavica 2005 84 8 788 793 2-s2.0-22844452941 10.1111/j.0001-6349.2005. 00714.x (Pubitemid 41039903)
55. Banerjee S., Smallwood A., Moorhead J., Chambers A. E., Papageorghiou A., Campbell S., Nicolaides K., Placental expression of interferon- γ (IFN- γ) and its receptor IFN- γ R2 fail to switch from early hypoxic to late normotensive development in preeclampsia. Journal of Clinical Endocrinology and Metabolism 2005 90 2 944 952 2-s2.0-14044262361 10.1210/jc.2004-1113 (Pubitemid 40279220)
56. Szekeres-Bartho J., Halasz M., Palkovics T., Progesterone in pregnancy; receptor-ligand interaction and signaling pathways. Journal of Reproductive Immunology 2009 83 1-2 60 64 2-s2.0-70450277204 10.1016/j.jri.2009.06.262
57. Dunn S. E., Bhat R., Straus D. S., Sobel R. A., Axtell R., Johnson A., Nguyen K., Mukundan L., Moshkova M., Dugas J. C., Chawla A., Steinman L., Peroxisome proliferator-activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity. Journal of Experimental Medicine 2010 207 8 1599 1608 2-s2.0-77955343205 10.1084/jem.20091663
58. 2 inhibits interleukin-1 β -induced nuclear factor- B in human amnion and myometrial cells: mechanisms and implications. Journal of Clinical Endocrinology and Metabolism 2005 90 6 3534 3543 (Pubitemid 41014324)
59. Chiron D., Bekeredjian-Ding I., Pellat-Deceunynck C., Bataille R., Jego G., Toll-like receptors: lessons to learn from normal and malignant human B cells. Blood 2008 112 6 2205 2213 2-s2.0-55249107642 10.1182/blood-2008-02- 140673
60. Carbone J., Gallego A., Lanio N., Navarro J., Orera M., Aguaron A., Fernandez-Cruz E., Sarmiento E., Quantitative abnormalities of peripheral blood distinct T, B, and natural killer cell subsets and clinical findings in obstetric antiphospholipid syndrome. Journal of Rheumatology 2009 36 6 1217 1225 2-s2.0-67149119570 10.3899/jrheum.081079
61. Zhou C. C., Ahmad S., Mi T., Abbasi S., Xia L., Day M. C., Ramin S. M., Ahmed A., Kellems R. E., Xia Y., Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension 2008 51 4 1010 1019 2-s2.0-40849105128 10.1161/HYPERTENSIONAHA.107. 097790 (Pubitemid 351398948)
62. Lamarca B., Wallace K., Herse F., Wallukat G., Martin J. N., Weimer A., Dechend R., Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes. Hypertension 2011 57 4 865 871 2-s2.0-79953177491 10.1161/HYPERTENSIONAHA.110.167569
63. Ray D. M., Akbiyik F., Bernstein S. H., Phipps R. P., CD40 engagement prevents peroxisome proliferator-activated receptor γ agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF- B-dependent mechanism. The Journal of Immunology 2005 174 7 4060 4069 2-s2.0-15444369546 (Pubitemid 40395982)
64. Garcia-Bates T. M., Baglole C. J., Bernard M. P., Murant T. I., Simpson-Haidaris P. J., Phipps R. P., Peroxisome proliferator-activated receptor γ ligands enhance human B cell antibody production and differentiation. The Journal of Immunology 2009 183 11 6903 6912 2-s2.0-73349104435 10.4049/jimmunol.0900324
65. Zhang J., Chen Z., Smith G. N., Croy B. A., Natural killer cell-triggered vascular transformation: maternal care before birth? Cellular and Molecular Immunology 2011 8 1 1 11 2-s2.0-79952522230 10.1038/cmi.2010.38
66. + myelomonocytic cells results in induction of Tregs and immunosuppression. Proceedings of the National Academy of Sciences of the United States of America 2010 107 26 11918 11923 2-s2.0-77955400639 10.1073/pnas.1001749107
67. Lin Y., Zhong Y., Shen W., Chen Y., Shi J., Di J., Zeng S., Saito S., TSLP-induced placental DC activation and IL-10+ NK cell expansion: comparative study based on BALB/c × C57BL/6 and NOD/SCID × C57BL/6 pregnant models. Clinical Immunology 2008 126 1 104 117 2-s2.0-37249063193 10.1016/j.clim.2007.09.006 (Pubitemid 350266456)
68. González I. T., Barrientos G., Freitag N., Otto T., Thijssen V. L., Moschansky P., von Kwiatkowski P., Klapp B. F., Winterhager E., Bauersachs S., Blois S. M., Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. PLoS One 2012 7 10 e46755
69. French A. R., Yokoyama W. M., Natural killer cells and viral infections. Current Opinion in Immunology 2003 15 1 45 51 2-s2.0-0037290831 10.1016/S095279150200002X (Pubitemid 35454191)
70. Zhang X., Rodriguez-Galán M. C., Subleski J. J., Ortaldo J. R., Hodge D. L., Wang J. M., Shimozato O., Reynolds D. A., Young H. A., Peroxisome proliferator-activated receptor- γ and its ligands attenuate biologic functions of human natural killer cells. Blood 2004 104 10 3276 3284 2-s2.0-8644236712 10.1182/blood-2004-02-0664 (Pubitemid 39507146)
71. Gosset P., Charbonnier A.-S., Delerive P., Peroxisome proliferator-activated receptor γ activators affect the maturation of human monocyte-derived dendritic cells. European Journal of Immunology 2001 31 10 2857 2865 (Pubitemid 32994536)
72. Nencioni A., Grünebach F., Zobywlaski A., Denzlinger C., Brugger W., Brossart P., Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor γ The Journal of Immunology 2002 169 3 1228 1235 2-s2.0-0036681640 (Pubitemid 34809163)
73. Desoye G., Hauguel-De Mouzon S., The human placenta in gestational diabetes mellitus: the insulin and cytokine network. Diabetes Care 2007 30 2 S120 S126 2-s2.0-34447118714 10.2337/dc07-s203 (Pubitemid 47036413)
74. Huppertz B., Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008 51 4 970 975 2-s2.0-40849096217 10.1161/HYPERTENSIONAHA.107.107607 (Pubitemid 351398986)
75. Chammas M. F., Nguyen T. M., Li M. A., Nuwayhid B. S., Castro L. C., Expectant management of severe preterm preeclampsia: is intrauterine growth restriction an indication for immediate delivery? American Journal of Obstetrics and Gynecology 2000 183 4 853 858 2-s2.0-0033783805 10.1067/mob.2000.109049
76. Walker J. J., Pre-eclampsia. The Lancet 2000 356 9237 1260 1265 2-s2.0-0034619029
77. Barbour L. A., McCurdy C. E., Hernandez T. L., Kirwan J. P., Catalano P. M., Friedman J. E., Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 2007 30 supplement 2 S112 S119 2-s2.0-34447119409 10.2337/dc07-s202 (Pubitemid 47036412)
78. Hawfield A., Freedman B. I., Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection. Therapeutic Advances in Cardiovascular Disease 2009 3 1 65 73 2-s2.0-68749093184 10.1177/1753944708097114
79. Gilbert J. S., Ryan M. J., Lamarca B. B., Sedeek M., Murphy S. R., Granger J. P., Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. American Journal of Physiology 2008 294 2 H541 H550 2-s2.0-39149111944 10.1152/ajpheart.01113.2007 (Pubitemid 351253261)
80. 2 on nitric oxide production in term placental tissues from diabetic women. Molecular Human Reproduction 2004 10 9 671 676 2-s2.0-5044245034 10.1093/molehr/gah090 (Pubitemid 39341588)
81. Lappas M., Permezel M., Rice G. E., Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2004 89 11 5627 5633 2-s2.0-8744224513 10.1210/jc.2003-032097 (Pubitemid 39518451)
82. 2 Mediators of Inflammation 2012 2012 12 416739 10.1155/2012/416739
83. Schaiff W. T., Barak Y., Sadovsky Y., The pleiotropic function of PPAR γ in the placenta. Molecular and Cellular Endocrinology 2006 249 1-2 10 15 2-s2.0-33645947963 10.1016/j.mce.2006.02.009
84. Martin H., Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. Mutation Research 2009 669 1-2 1 7 2-s2.0-70349113042 10.1016/j.mrfmmm.2009.06.009