Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-γ: Effect of 15-deoxy-δ12,14-PGJ2 and troglitazone

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 10, 2002, Pages 4667-4672

  Lappas, Martha ^a   Permezel, Michael ^a   Georgiou, Harry M ^a   Rice, Gregory E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CELL NUCLEUS RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

AMNION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; DECIDUA; DNA BINDING; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; HUMAN; HUMAN TISSUE; IMMUNOREGULATION; LABOR; PLACENTA DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; REGULATORY MECHANISM; TROPHOBLAST;

AMNION; CHORION; CHROMANS; CULTURE TECHNIQUES; DECIDUA; DNA; FEMALE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; L-LACTATE DEHYDROGENASE; LIGANDS; NF-KAPPA B; PLACENTA; PREGNANCY; PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 0036774446     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020613     Document Type: Article

References (22)

1. Murphy GJ, Holder JC 2000 PPAR-γ agonists: Therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 21:469-474
2. Jiang C, Ting AT, Seed B 1998 PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86
3. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK 1998 The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82
4. Su CG, Wen X, Bailey S, Jiang W, Rangwala SM, Keilbaugh SA, Flanigan A, Murthy S, Lazar MA, Wu GD 1999 A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response. J Clin Invest 104:383-389
5. 2 in the regulation of microglial functions. Eur J Neurosci 12:2215-2223
6. Takano H, Nagai T, Asakawa M, Toyozaki T, Oka T, Komuro I, Saito T, Masuda Y 2000 Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumour necrosis factor-alpha expression in neonatal rat cardiac myocytes. Circ Res 87:596-602
7. Ghanim H, Garg R, Aljada A, Mohanty P, Kumbkarni Y, Assian E, Hamouda W, Dandona P 2001 Suppression of nuclear factor-κB and stimulation of inhibitor κB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J Clin Endocrinol Metab 86:1306-1312
8. 2 receptor, peroxisome proliferator activated receptor-γ (PPARγ) is expressed in human gestational tissues and is functionally active in JEG3 choriocarcinoma cells. Placenta 21:436-440
9. Desvergne B, Ipenberg A, Devchand PR, Wahli W 1998 The peroxisome proliferator-activated receptors at the cross-road of diet and hormone signalling. J Steroid Biochem Mol Biol 65:65-74
10. Willson TM, Wahli W 1997 Peroxisome proliferator-activated receptor agonists. Curr Opin Chem Biol 1:235-241
11. Laham N, Brennecke SP, Bendtzen K, Rice GE 1996 Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment. J Endocrinol 149:431-439
12. Bartlett MS, Kendall DG 1946 The statistical analysis of variance - Heterogeneity and the logarithmic transformation. J R Stat Soc 8:128-138
13. Rice GE 2001 Cytokines and the initiation of parturition. Endocrinology of parturition. Basic Sci 27:113-146
14. Lappas M, Georgiou HM, Permezel M, Rice GE 2002 Nuclear factor kappa B regulation of pro-inflammatory cytokines in human gestational tissues in vitro. Biol Reprod 67:668-673
15. 2, a ligand for peroxisome proliferator-activated receptor-γ, induces apoptosis in JEG3 choriocarcinoma cells. Biochem Biophys Res Commun 262:579-585
16. Waite LL, Person EC, Zhou Y, Lim K-H, Scanlan TS, Taylor RN 2000 Placental peroxisome proliferator-activated receptor-γ is up-regulated by pregnancy serum. J Clin Endocrinol Metab 85:3808-3814
17. Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM 1999 PPARγ is required for placental, cardiac, and adipose tissue development. Mol Cell 4:585-595
18. 2 derivative induces apoptosis in amnion-derived WISH cells. J Soc Gynecol Inv 6:75A
19. Schaiff WT, Carlson MG, Smith SD, Levy R, Nelson DM, Sadovsky Y 2000 Peroxisome proliferator-activated receptor-γ modulates differentiation of human trophoblast in a ligand-specific manner. J Clin Endocrinol Metab 85:3874-3881
20. 2. Prostaglandins Leukot Med 8:383-387
21. Ma H, Sprecher HW, Kolattukudy PE 1998 Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPAR-γ expressing tissue. J Biol Chem 273:30131-30138
22. 2 by rat uterine tissue throughout the sex cycle. Effects of 17-beta-estradiol and progesterone. Prostaglandins Leukot Essent Fatty Acids 51:47-50