Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205

Blood

Volumn 121, Issue 9, 2013, Pages 1584-1594

  Leung, Carol S ^a   Maurer, Michael A ^a   Meixlsperger, Sonja ^a   Lippmann, Anne ^a   Cheong, Cheolho ^b   Zuo, Jianmin ^c   Haigh, Tracey A ^c   Taylor, Graham S ^c   Münz, Christian ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; DEC 205; EPSTEIN BARR VIRUS ANTIGEN 1; LATENT MEMBRANE PROTEIN 1; LYMPHOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ASSAY; CELL CLONE; CELL COMPARTMENTALIZATION; CELL STIMULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG TARGETING; ENDOSOME; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN TARGETING; T LYMPHOCYTE; VIRUS CELL TRANSFORMATION; WESTERN BLOTTING;

EID: 84876496885     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-08-450775     Document Type: Article

References (45)

1. Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol. 2007;37(Suppl 1): S53-S60. (Pubitemid 350131268)
2. Mǔnz C, Steinman RM, Fujii S. Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med. 2005;202(2):203-207. (Pubitemid 41043815)
3. Steinman RM. The control of immunity and tolerance by dendritic cell. Pathol Biol. 2003;51(2):59-60. (Pubitemid 36427570)
4. Palucka K, Ueno H, Roberts L, Fay J, Banchereau J. Dendritic cells: are they clinically relevant? Cancer J. 2010;16(4):318-324.
5. Bonifaz LC, Bonnyay DP, Charalambous A, et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T-cell vaccination. J Exp Med. 2004;199(6):815-824. (Pubitemid 38375201)
6. Idoyaga J, Lubkin A, Fiorese C, et al. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci U S A. 2011;108(6):2384-2389.
7. Bozzacco L, Trumpfheller C, Siegal FP, et al. DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A. 2007;104(4):1289-1294. (Pubitemid 46183997)
8. Gurer C, Strowig T, Brilot F, et al. Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. Blood. 2008;112(4): 1231-1239.
9. Birkholz K, Schwenkert M, Kellner C, et al. Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation. Blood. 2010;116(13):2277-2285.
10. Kǔppers R. B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol. 2003;3(10):801-812. (Pubitemid 37328658)
11. Thorley-Lawson DA. Epstein-Barr virus: exploiting the immune system. Nat Rev Immunol. 2001; 1(1):75-82. (Pubitemid 33741978)
12. de Campos-Lima PO, Torsteinsdottir S, Cuomo L, et al. Antigen processing and presentation by EBV-carrying cell lines: cell-phenotype dependence and influence of the EBV-encoded LMP1. Int J Cancer. 1993;53(5):856-862. (Pubitemid 23100133)
13. Rowe M, Khanna R, Jacob CA, et al. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression. Eur J Immunol. 1995;25(5):1374-1384.
14. Falk K, Rǒtzschke O, Deres K, Metzger J, Jung G, Rammensee HG. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T-cell epitope forecast. J Exp Med. 1991;174(2): 425-434.
15. Chicz RM, Urban RG, Lane WS, et al. Predominant naturally processed peptides bound to HLADR1 are derived from MHC-related molecules and are heterogeneous in size. Nature. 1992; 358(6389):764-768.
16. Lanzavecchia A, Abrignani S, Scheidegger D, Obrist R, Dorken B, Moldenhauer G. Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets. J Exp Med. 1988;167(2):345-352. (Pubitemid 18073640)
17. Barrault DV, Knight AM. Distinct sequences in the cytoplasmic domain of complement receptor 2 are involved in antigen internalization and presentation. J Immunol. 2004;172(6):3509-3517. (Pubitemid 38337931)
18. Antoniou AN, Watts C. Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B-cell isoform of FcgammaRII. Eur J Immunol. 2002;32(2):530-540. (Pubitemid 34173344)
19. Leung CS, Haigh TA, Mackay LK, Rickinson AB, Taylor GS. Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display. Proc Natl Acad Sci U S A. 2010;107(5): 2165-2170.
20. Kato M, McDonald KJ, Khan S, et al. Expression of human DEC-205 (CD205) multilectin receptor on leukocytes. Int Immunol. 2006;18(6):857-869. (Pubitemid 43983281)
21. Kamphorst AO, Guermonprez P, Dudziak D, Nussenzweig MC. Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol. 2010; 185(6):3426-3435.
22. Victora GD, Schwickert TA, Fooksman DR, et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010;143(4):592-605.
23. Guo M, Gong S, Maric S, et al. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum Immunol. 2000;61(8): 729-738.
24. Cheong C, Choi JH, Vitale L, et al. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood. 2010;116(19):3828-3838.
25. Verspurten J, Gevaert K, Declercq W, Vandenabeele P. SitePredicting the cleavage of proteinase substrates. Trends Biochem Sci. 2009;34(7):319-323.
26. Mahnke K, Guo M, Lee S, et al. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol. 2000;151(3): 673-684.
27. Gu H, Zou YR, Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through CreloxP-mediated gene targeting. Cell. 1993;73(6): 1155-1164. (Pubitemid 23180489)
28. Trumpfheller C, Finke JS, Lopez CB, et al. Intensified and protective CD4+ T-cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med. 2006;203(3):607-617.
29. Trumpfheller C, Caskey M, Nchinda G, et al. The microbial mimic poly IC induces durable and protective CD4+ T-cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A. 2008;105(7):2574-2579. (Pubitemid 351520555)
30. Flynn BJ, Kastenmuller K, Wille-Reece U, et al. Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. Proc Natl Acad Sci U S A. 2011; 108(17):7131-7136.
31. Bickham K, Goodman K, Paludan C, et al. Dendritic cells initiate immune control of epstein-barr virus transformation of B lymphocytes in vitro. J Exp Med. 2003;198(11):1653-1663. (Pubitemid 37494158)
32. Babcock GJ, Hochberg D, Thorley-Lawson AD. The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity. 2000;13(4):497-506.
33. Kurth J, Spieker T, Wustrow J, et al. EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B-cell compartment and establishing latency. Immunity. 2000;13(4):485-495.
34. Sancho D, Mourao-Sa D, Joffre OP, et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest. 2008; 118(6):2098-2110. (Pubitemid 351872329)
35. Romani N, Thurnher M, Idoyaga J, Steinman RM, Flacher V. Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy. Immunol Cell Biol. 2010;88(4):424-430.
36. Pantel A, Cheong C, Dandamudi D, et al. A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo. Eur J Immunol. 2012;42(1):101-109.
37. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005;307(5715):1630-1634. (Pubitemid 40354746)
38. Delamarre L, Couture R, Mellman I, Trombetta ES. Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med. 2006; 203(9):2049-2055. (Pubitemid 44352226)
39. Savina A, Jancic C, Hugues S, et al. NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell. 2006;126(1):205-218. (Pubitemid 44026552)
40. Gondre-Lewis TA, Moquin AE, Drake Jr. Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes. J Immunol. 2001;166(11):6657-6664. (Pubitemid 32467207)
41. O'Neill SK, Veselits ML, Zhang M, et al. Endocytic sequestration of the B-cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009;106(15):6262-6267.
42. Chaturvedi A, Dorward D, Pierce SK. The B-cell receptor governs the subcellular location of Tolllike receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity. 2008;28(6): 799-809.
43. Burgdorf S, Kautz A, Bohnert V, Knolle PA, Kurts C. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T-cell activation. Science. 2007;316(5824):612-616. (Pubitemid 46683149)
44. Saveanu L, Carroll O, Weimershaus M, et al. IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science. 2009;325(5937):213-217.
45. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007;449(7161):419-426. (Pubitemid 47509552)