The implantable and biodegradable PHBHHx 3D scaffolds loaded with protein-phospholipid complex for sustained delivery of proteins

Pharmaceutical Research

Volumn 30, Issue 4, 2013, Pages 1077-1085

  Peng, Qiang ^a,b   Yang, Yong Jie ^a   Zhang, Ting ^a   Wu, Cheng Yu ^a   Yang, Qin ^a   Sun, Xun ^a   Gong, Tao ^a   Zhang, Ling ^c,d   Zhang, Zhi Rong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d NONE   (United Kingdom)

Author keywords

drug delivery; insulin; PHBHHx scaffold; phospholipid complex; tissue engineering

Indexed keywords

[POLY(3 HYDROXYBUTYRATE CO 3 HYDROXYHEXANOATE)]; BIOMATERIAL; DRUG CARRIER; INSULIN; MACROGOL 2000; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; FREEZE DRYING; IMPLANT; IN VITRO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

3-HYDROXYBUTYRIC ACID; ANIMALS; BIOCOMPATIBLE MATERIALS; CAPROATES; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE SCAFFOLDS;

EID: 84876495541     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0944-9     Document Type: Article

References (36)

1. Seyednejad H, Ghassemi AH, van Nostrum CF, Vermonden T, Hennink WE. Functional aliphatic polyesters for biomedical and pharmaceutical applications. J Control Release. 2011;152:168-76.
2. Ladewig K. Drug delivery in soft tissue engineering. Expert Opin Drug Deliv. 2011;8:1175-88.
3. Bawa R. Regulating nanomedicine - can the FDA handle it? Curr Drug Deliv. 2011;8:227-34.
4. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33:381-94.
5. Chen FM, Zhang M, Wu ZF. Toward delivery of multiple growth factors in tissue engineering. Biomaterials. 2010;31:6279-308.
6. Moss AJ, Sharma S, Brindle NP. Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering. Biochem Soc Trans. 2009;37:717-21.
7. Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7:771-82.
8. Robinsonand SN, Talmadge JE. Sustained release of growth factors. In Vivo. 2002;16:535-40.
9. Thomopoulos S, Zaegel M, Das R, Harwood FL, Silva MJ, Amiel D, et al. PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling. J Orthop Res. 2007;25:1358-68.
10. Shangguan YY, Wang YW, Wu Q, Chen GQ. The mechanical properties and in vitro biodegradation and biocompatibility of UV-treated poly(3-hydroxybutyrate- co-3-hydroxyhexanoate). Biomaterials. 2006;27:2349-57.
11. Chen GQ. A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry. Chem Soc Rev. 2009;38:2434-46.
12. Yang M, Zhu S, Chen Y, Chang Z, Chen G, Gong Y, et al. Studies on bone marrow stromal cells affinity of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate). Biomaterials. 2004;25:1365-73.
13. Qu XH, Wu Q, Zhang KY, Chen GQ. In vivo studies of poly(3- hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions. Biomaterials. 2006;27:3540-8.
14. Wang Y, Bian YZ, Wu Q, Chen GQ. Evaluation of three-dimensional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. Biomaterials. 2008;29:2858-68.
15. Wang Y, Gao R, Wang PP, Jian J, Jiang XL, Yan C, et al. The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARgamma signaling. Biomaterials. 2012;33:485-93.
16. Yu BY, Chen PY, Sun YM, Lee YT, Young TH. Response of human mesenchymal stem cells (hMSCs) to the topographic variation of poly(3-hydroxybutyrate-co-3- hydroxyhexanoate) (PHBHHx) films. J Biomater Sci Polym Ed. 2012;23:1-26.
17. You M, Peng G, Li J, Ma P, Wang Z, Shu W, et al. Chondrogenic differentiation of human bone marrow mesenchymal stem cells on polyhydroxyalkanoate (PHA) scaffolds coated with PHA granule binding protein PhaP fused with RGD peptide. Biomaterials. 2011;32:2305-13.
18. Zhou J, Peng SW, Wang YY, Zheng SB, Wang Y, Chen GQ. The use of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tarsal repair in eyelid reconstruction in the rat. Biomaterials. 2010;31:7512-8.
19. Peng Q, Zhang ZR, Gong T, Chen GQ, Sun X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials. 2012;33:1583-8.
20. Dobson CM. Principles of protein folding, misfolding and aggregation. Semin Cell Dev Biol. 2004;15:3-16.
21. Frokjaerand S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov. 2005;4:298-306.
22. Tiwari S, Verma SK, Agrawal GP, Vyas SP. Viral protein complexed liposomes for intranasal delivery of hepatitis B surface antigen. Int J Pharm. 2011;413:211-9.
23. Grdisa M. The delivery of biologically active (therapeutic) peptides and proteins into cells. Curr Med Chem. 2011;18:1373-9.
24. Garg T, Singh O, Arora S, Murthy R. Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst. 2012;29:1-63.
25. Sokolsky-Papkov M, Agashi K, Olaye A, Shakesheff K, Domb AJ. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev. 2007;59:187-206.
26. Jaklenec A, Wan E, Murray ME, Mathiowitz E. Novel scaffolds fabricated from protein-loaded microspheres for tissue engineering. Biomaterials. 2008;29:185-92.
27. Huang W, Shi X, Ren L, Du C, Wang Y. PHBV microspheres-PLGA matrix composite scaffold for bone tissue engineering. Biomaterials. 2010;31:4278-85.
28. Claase MB, Grijpma DW, Mendes SC, De Bruijn JD, Feijen J. Porous PEOT/PBT scaffolds for bone tissue engineering: preparation, characterization, and in vitro bone marrow cell culturing. J Biomed Mater Res A. 2003;64:291-300.
29. Moshfeghian A, Tillman J, Madihally SV. Characterization of emulsified chitosan-PLGA matrices formed using controlled-rate freezing and lyophilization technique. J Biomed Mater Res A. 2006;79:418-30.
30. Cui F, Shi K, Zhang L, Tao A, Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J Control Release. 2006;114:242-50.
31. Peng Q, Gong T, Zuo J, Liu J, Zhao D, Zhang Z. Enhanced oral bioavailability of salvianolic acid B by phospholipid complex loaded nanoparticles. Pharmazie. 2008;63:661-6.
32. Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release. 2007;122:141-50.
33. Kim BS, Oh JM, Hyun H, Kim KS, Lee SH, Kim YH, et al. Insulin-loaded microcapsules for in vivo delivery. Mol Pharm. 2009;6:353-65.
34. Abu II H, Higashi T, Anno T, Motoyama K, Abd-ElGawad AE, El-Shabouri MH, et al. Potential use of gamma-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin. Int J Pharm. 2010;392:83-91.
35. Wang Y-W, Mo W, Yao H, Wu Q, Chen J, Chen G-Q. Biodegradation studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Polym Degrad Stab. 2004;85:815-21.
36. Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev. 1998;19:608-24.