CAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung cancer cells

FEBS Letters

Volumn 587, Issue 9, 2013, Pages 1373-1378

  Jeong, Min Jae ^a   Kim, Eui Jun ^a   Cho, Eun Ah ^a   Ye, Sang Kyu ^a   Kang, Gyeong Hoon ^a   Juhnn, Yong Sung ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

cAMP signaling; Epac; p300; p38 MAPK; Proteasome

Indexed keywords

BREFELDIN A; CELL PROTEIN; CYCLIC AMP; E1A ASSOCIATED P300 PROTEIN; EXCHANGE PROTEIN ACTIVATED BY CAMP; EXCHANGE PROTEIN ACTIVATED BY CAMP1; GALPHAS PROTEIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; EPIGENETICS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CELL LINE, TUMOR; CYCLIC AMP; E1A-ASSOCIATED P300 PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LUNG NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84876479535     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.03.010     Document Type: Article

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