The cAMP signaling system inhibits the repair of γ-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells

Biochemical and Biophysical Research Communications

Volumn 422, Issue 2, 2012, Pages 256-262

  Cho, Eun Ah ^a   Juhnn, Yong Sung ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

8 pCPT 2' O Me cAMP; CAMP signaling system; DNA repair; Epac; Epac: PKA; Ionizing radiation; Lung cancer cells; XRCC1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP 1; FORSKOLIN; ISOPRENALINE; MESSENGER RNA; PROTEASOME; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GAMMA RADIATION; HALF LIFE TIME; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CELL LINE, TUMOR; CYCLIC AMP; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GAMMA RAYS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84861659777     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.139     Document Type: Article

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