Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK

Cytotechnology

Volumn 65, Issue 3, 2013, Pages 447-455

  Zhang, Wenjing ^a   Lan, Yan ^b   Huang, Qilai ^a,b   Hua, Zichun ^a,b  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^b NANJING UNIVERSITY   (China)

Author keywords

Apoptosis; Galangin; Malignant melanoma; Mitochondria; p38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GALANGIN; HOE 33342; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROCASPASE 9;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL VIABILITY; FLOW CYTOMETRY; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING;

ALPINIA OFFICINARUM;

EID: 84876478821     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-012-9499-1     Document Type: Article

References (28)

1. Atallah E, Flaherty L (2005) Treatment of metastatic malignant melanoma. Curr Treat Options Oncol 6:185-193
2. Barbarić M, Mišković K, Bojić M, Lončar MB, Smolčić-Bubalo A, Debeljak Z, Medić-Šarić M (2011) Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. J Ethnopharmacol 135:772-778
3. Bestwick CS, Milne L (2006) Influence of galangin on HL-60 cell proliferation and survival. Cancer Lett 243:80-89
4. Chen Y, Bathula SR, Yang Q, Huang L (2010) Targeted nanoparticles deliver siRNA to melanoma. J Invest Dermatol 130:2790-2798
5. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16
6. Gomez-Lazaro M, Galindo MF, de Melero-Fernandez Mera RM, Fernandez-Gómez FJ, Concannon CG, Segura MF, Comella JX, Prehn JH, Jordan J (2007) Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol Pharmacol 71:736-743
7. Han J, Sun P (2007) The pathways to tumor suppression via route p38. Trends Biochem Sci 32:364-371
8. Heo MY, Jae LH, Jung SS, Au WW (1996) Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice. Mutat Res 360:37-41
9. Heo MY, Sohn SJ, Au WW (2001) Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate. Mutat Res 488:135-150
10. Kajiya K, Ichiba M, Kuwabara M, Kumazawa S, Nakayama T (2001) Role of lipophilicity and hydrogen peroxide formation in the cytotoxicity of flavonols. Biosci Biotechnol Biochem 65:1227-1229
11. Kennedy NJ, Davis RJ (2003) Role of JNK in tumor development. Cell Cycle 2:199-201
12. Kim JD, Liu L, Guo W, Meydani M (2006) Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem 17:165-176
13. Lavrik IN, Golks A, Krammer PH (2005) Caspases: pharmacological manipulation of cell death. J Clin Invest 115:2665-2672
14. Lopez-Bergami P (2011) The role of mitogen- and stress-activated protein kinase pathways in melanoma. Pigment Cell Melanoma Res 24:902-921
15. Lu YH, Lin T, Wang ZT, Wei DZ, Xiang HB (2007) Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells. J Enzyme Inhib Med Chem 22:433-438
16. Lu J, Xu SY, Zhang QG, Xu R, Lei HY (2011) Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. Eur J Pharmacol 657:51-58
17. Matsuda H, Nakashima S, Oda Y, Nakamura S, Yoshikawa M (2009) Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells. Bioorg Med Chem 17:6048-6053
18. Murray TJ, Yang X, Sherr DH (2006) Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. Breast Cancer Res 8:R17
19. Olson JM, Hallahan AR (2004) p38 MAP kinase: a convergence point in cancer therapy. Trends Mol Med 10:125-129
20. Ratheesh A, Ingle A, Gude RP (2007) Pentoxifylline modulates cell surface integrin expression and integrin mediated adhesion of B16F10 cells to extracellular matrix components. Cancer Biol Ther 6:1743-1752
21. Russo A, Longo R, Vanella A (2002) Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 73:S21-S29
22. Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin CP, Xia M (2012) Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol Genomics 44:495-503
23. Shimizu T, Nakazato T, Xian MJ, Sagawa M, Ikeda Y, Kizaki M (2006) Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem Pharmacol 71:742-750
24. Sohn SJ, Huh IH, Au WW, Heo MY (1998) Antigenotoxicity of galangin against N-methyl-N-nitrosourea. Mutat Res 402:231-236
25. Szliszka E, Czuba ZP, Bronikowska J, Mertas A, Paradysz A, Krol W (2011) Ethanolic extract of propolis augments TRAIL-induced apoptotic death in prostate cancer cells. Evid Based Complement Alternat Med 2011:535172
26. Tan Y, Yu R, Pezzuto JM (2003) Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin Cancer Res 9:2866-2875
27. Wang ZJ, Zhang Q, Zhao XH (2009) Suppressive effect of galangin on human esophageal squamous cell carcinoma cell line KYSE-510. Chin J Biochem Mol Biol 25:563-569
28. Zhang HT, Luo H, Wu J, Lan LB, Fan DH, Zhu KD, Chen XY, Wen M, Liu HM (2010) Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway. World J Gastroenterol 16:3377-3384