Antigenotoxicity of galangin against N-methyl-N-nitrosourea

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 402, Issue 1-2, 1998, Pages 231-236

  Sohn, Su Jung ^a   Huh, In Hoe ^b   Au, William W ^c   Heo, Moon Young ^d  

^a Korea Food and Drug Administration   (South Korea)

^b Chung Ang University   (South Korea)

^c University of Texas Medical Branch School of Medicine   (United States)

^d Kangwon National University   (South Korea)

Author keywords

Ames test; Anticlastogenicity; Antimutagenicity; Flavonoid; Galangin; Micronucleus test; N methyl N nitrosourea

Indexed keywords

ANTIMUTAGENIC AGENT; CLASTOGEN; GALANGIN; METHYLNITROSOUREA;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE; GENOTOXICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ANIMALS; ANTIMUTAGENIC AGENTS; BIOTRANSFORMATION; BONE MARROW CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; MALE; METHYLNITROSOUREA; MICE; MICRONUCLEUS TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM;

EID: 0032543402     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00302-3     Document Type: Conference Paper

References (19)

1. [1] J. Kuhnau, The flavonoid: A class of semi-essential food components: Their role in human nutrition, World Rev. Nutr. Diet 24 (1976) 117-120.
2. [2] A.R. Francis, T.K. Shethy, R.K. Bhattacharya, Modifying role of dietary factors on the mutagenicity of aflatoxin B1: In vitro effect of plant flavonoids, Mutation Res. 222 (1988) 393-401.
3. [3] L.W. Wattenberg, J.L. Leong, Inhibition of carcinogenic action of benzo(a)pyrene by flavones, Cancer Res. 30 (1970) 1922-1925.
4. [4] M.T. Huang, A.W. Wood, H.L. Newmark, J.M. Sayer, H. Yagi, D.M. Jerina, A.M. Conney, Inhibition of the mutagenicity of bay region diol epoxides of polycyclic aromatic hydrocarbons by plant flavonoids, Carcinogenesis 4 (1983) 1631-1637.
5. [5] M.E. Wall, M.C. Wani, G. Manikumar, P. Arrahm, H. Taylor, T.J. Hughes, J. Waner, R. McGivney, Plant antimutagenic agents: II. Flavonoids, J. Nat. Prod. 51 (1988) 1084-1091.
6. 4-induced microsomal lipid peroxidation, Experientia 47 (1991) 195-199.
7. [7] M.Y. Heo, K.S. Yu, K.H. Kim, H.P. Kim, W.W. Au, Anticlastogenic effect of flavonoids against mutagen-induced micronuclei in mice, Mutation Res. 284 (1992) 243-249.
8. [8] M.Y. Heo, C.H. Kwon, D.H. Sohn, S.J. Lee, S.W. Kim, J.H. Kim, W.W. Au, Effects of flavonol derivatives on the micronuclei formation by N-methyl-N′-nitro-N-nitrosoguanidine and the enhancement of bleomycin-induced chromosome aberration by N-methyl-N′-nitro-N-nitrosoguanidine, Arch. Pharm. Res. 16 (1993) 196-204.
9. [9] M.Y. Heo, S.J. Lee, C.H. Kwon, S.W. Kim, D.H. Shon, W.W. Au, Anticlastogenic effects of galangin against bleomycin induced chromosome aberrations in mouse spleen lymphocytes, Mutation Res. 311 (1994) 225-229.
10. [10] S.J. Lee, C.H. Kwon, D.H. Sohn, M.Y. Heo, W.W. Au, Anticlastogenic effects of galangin against N-methyl-N′-nitro-N-nitrosoguanidine induced micronuclei in bone marrow cells of C57 BL/6 mice, J. Appl. Pharmacol. 2 (1993) 183-187.
11. [11] M.Y. Heo, S.J. Lee, C.H. Kwon, S.W. Kim, D.H. Sohn, W.W. Au, Anticlastogenic effects of galangin against bleomycin-induced chromosomal aberrations in mouse spleen lymphocytes, Mutation Res. 311 (1994) 225-229.
12. [12] D.M. Maron, B.N. Ames, Revised methods for the Salmonella mutagenicity test, Mutation Res. 113 (1983) 173-215.
13. [13] W. Schmid, The micronucleus test, Mutation Res. 31 (1975) 9-15.
14. [14] R. Dixit, B. Gold, Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid, Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 8039-8043.
15. [15] A.K. Verma, J.A. Johnson, M.N. Gould, M.A. Tanner, Inhibition of 7,12-dimethylbenz(9a)anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin, Cancer Res. 48 (1988) 5754-5758.
16. [16] E.E. Deschner, J. Ruperrto, G. Wong, H.L. Newmark, Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia, Carcinogenesis 12 (1991) 1193-1196.
17. [17] M.Y. Heo, H.J. Lee, S.J. Sohn, W.W. Au, Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice, Mutation Res. 360 (1996) 37-41.
18. [18] S.J. Sohn, J.H. Kim, Y.J. Kim, I.H. Huh, M.Y. Heo, Inhibition of N-methyl-N-nitrosourea induced sister-chromatid exchange and DNA methylation by galangin, Yakhak Hoeji 39 (1995) 94-101.
19. [19] R. Schoenthal, Carcinogenicity of N-methyl-N′-methyl-N-nitroso guanidine, Cancer Res. 30 (1966) 455-465.