-
1
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley SR, Schooley K, Smolak PJ et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3: 673-82.
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
-
2
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996; 271: 12687-90.
-
(1996)
J Biol Chem
, vol.271
, pp. 12687-12690
-
-
Pitti, R.M.1
Marsters, S.A.2
Ruppert, S.3
Donahue, C.J.4
Moore, A.5
Ashkenazi, A.6
-
3
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2002; 2: 420-30.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
4
-
-
9144234147
-
TRAIL and its receptors as targets for cancer therapy
-
Yagita H, Takeda K, Hayakawa Y, Smyth MJ, Okumura K. TRAIL and its receptors as targets for cancer therapy. Cancer Sci 2004; 95: 777-83.
-
(2004)
Cancer Sci
, vol.95
, pp. 777-783
-
-
Yagita, H.1
Takeda, K.2
Hayakawa, Y.3
Smyth, M.J.4
Okumura, K.5
-
5
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/TRAIL
-
Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010; 29: 4752-65.
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.1
Ashkenazi, A.2
-
6
-
-
0346792725
-
TRAIL and apoptosis induction by TNF-family death receptors
-
Wang S, El-Deiry WS. TRAIL and apoptosis induction by TNF-family death receptors. Oncogene 2003; 22: 8628-33.
-
(2003)
Oncogene
, vol.22
, pp. 8628-8633
-
-
Wang, S.1
El-Deiry, W.S.2
-
7
-
-
71749102407
-
TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies
-
Holoch PA, Griffith TS. TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur J Pharmacol 2009; 625: 63-72.
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 63-72
-
-
Holoch, P.A.1
Griffith, T.S.2
-
8
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest. 1999; 104: 155-62.
-
(1999)
J Clin Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
-
9
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu W, Zhao L et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 2001; 7: 954-60.
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
-
10
-
-
0037226644
-
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer
-
Seki N, Hayakawa Y, Brooks AD et al. Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer. Cancer Res 2003; 63: 207-13.
-
(2003)
Cancer Res
, vol.63
, pp. 207-213
-
-
Seki, N.1
Hayakawa, Y.2
Brooks, A.D.3
-
11
-
-
0035137696
-
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
-
Takeda K, Hayakawa Y, Smyth MJ et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001; 7: 94-100.
-
(2001)
Nat Med
, vol.7
, pp. 94-100
-
-
Takeda, K.1
Hayakawa, Y.2
Smyth, M.J.3
-
12
-
-
84875230886
-
On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
-
Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A, Ford HL. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene 2013; 32: 1341-50.
-
(2013)
Oncogene
, vol.32
, pp. 1341-1350
-
-
Dimberg, L.Y.1
Anderson, C.K.2
Camidge, R.3
Behbakht, K.4
Thorburn, A.5
Ford, H.L.6
-
14
-
-
0038751850
-
Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Schneider P, Olson D, Tardivel A et al. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem 2003; 278: 5444-54.
-
(2003)
J Biol Chem
, vol.278
, pp. 5444-5454
-
-
Schneider, P.1
Olson, D.2
Tardivel, A.3
-
15
-
-
0035523826
-
How melanoma cells evade trail-induced apoptosis
-
Hersey P, Zhang XD. How melanoma cells evade trail-induced apoptosis. Nat Rev Cancer 2001; 1: 142-50.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 142-150
-
-
Hersey, P.1
Zhang, X.D.2
-
16
-
-
0031406386
-
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
-
Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity 1997; 7: 821-30.
-
(1997)
Immunity
, vol.7
, pp. 821-830
-
-
Chaudhary, P.M.1
Eby, M.2
Jasmin, A.3
Bookwalter, A.4
Murray, J.5
Hood, L.6
-
17
-
-
0032697485
-
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways
-
Hu WH, Johnson H, Shu HB. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem 1999; 274: 30603-10.
-
(1999)
J Biol Chem
, vol.274
, pp. 30603-30610
-
-
Hu, W.H.1
Johnson, H.2
Shu, H.B.3
-
18
-
-
0031405585
-
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
-
Schneider P, Thome M, Burns K et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity 1997; 7: 831-6.
-
(1997)
Immunity
, vol.7
, pp. 831-836
-
-
Schneider, P.1
Thome, M.2
Burns, K.3
-
19
-
-
33749578608
-
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells
-
Khanbolooki S, Nawrocki ST, Arumugam T et al. Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells. Mol Cancer Ther 2006; 5: 2251-60.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2251-2260
-
-
Khanbolooki, S.1
Nawrocki, S.T.2
Arumugam, T.3
-
20
-
-
67649304670
-
The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells
-
Büneker C, Mohr A, Zwacka RM. The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells. Oncol Rep 2009; 21: 1289-95.
-
(2009)
Oncol Rep
, vol.21
, pp. 1289-1295
-
-
Büneker, C.1
Mohr, A.2
Zwacka, R.M.3
-
21
-
-
0035291880
-
Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
-
Nguyen T, Zhang XD, Hersey P. Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Clin Cancer Res 2001; 7: 966s-73s.
-
(2001)
Clin Cancer Res
, vol.7
-
-
Nguyen, T.1
Zhang, X.D.2
Hersey, P.3
-
22
-
-
0013583837
-
Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma
-
Zhang XD, Franco A, Myers K, Gray C, Nguyen T, Hersey P. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. Cancer Res 1999; 59: 2747-53.
-
(1999)
Cancer Res
, vol.59
, pp. 2747-2753
-
-
Zhang, X.D.1
Franco, A.2
Myers, K.3
Gray, C.4
Nguyen, T.5
Hersey, P.6
-
23
-
-
0033567099
-
Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells
-
Kayagaki N, Yamaguchi N, Nakayama M et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol. 1999; 163: 1906-13.
-
(1999)
J Immunol.
, vol.163
, pp. 1906-1913
-
-
Kayagaki, N.1
Yamaguchi, N.2
Nakayama, M.3
-
24
-
-
84856521363
-
Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
-
Drobits B, Holcmann M, Amberg N et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest. 2012; 122: 575-85.
-
(2012)
J Clin Invest.
, vol.122
, pp. 575-585
-
-
Drobits, B.1
Holcmann, M.2
Amberg, N.3
-
25
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-59.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
26
-
-
68849108869
-
Inflammation and cancer: how friendly is the relationship for cancer patients?
-
Aggarwal BB, Gehlot P. Inflammation and cancer: how friendly is the relationship for cancer patients? Curr Opin Pharmacol 2009; 9: 351-69.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 351-369
-
-
Aggarwal, B.B.1
Gehlot, P.2
-
27
-
-
0035340285
-
The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells
-
Franco AV, Zhang XD, Van Berkel E et al. The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells. J Immunol. 2001; 166: 5337-45.
-
(2001)
J Immunol.
, vol.166
, pp. 5337-5345
-
-
Franco, A.V.1
Zhang, X.D.2
Van Berkel, E.3
-
28
-
-
4444294803
-
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation
-
Deeb D, Jiang H, Gao X et al. Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. Mol Cancer Ther 2004; 3: 803-12.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 803-812
-
-
Deeb, D.1
Jiang, H.2
Gao, X.3
-
29
-
-
0032508414
-
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998; 281: 1680-3.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin, A.S.5
-
30
-
-
0036792685
-
TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
-
Wajant H, Pfizenmaier K, Scheurich P. TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis 2002; 7: 449-59.
-
(2002)
Apoptosis
, vol.7
, pp. 449-459
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
31
-
-
0034676268
-
Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis
-
Hinz S, Trauzold A, Boenicke L et al. Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene 2000; 19: 5477-86.
-
(2000)
Oncogene
, vol.19
, pp. 5477-5486
-
-
Hinz, S.1
Trauzold, A.2
Boenicke, L.3
-
32
-
-
9144234685
-
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
-
Schimmer AD, Welsh K, Pinilla C et al. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 2004; 5: 25-35.
-
(2004)
Cancer Cell
, vol.5
, pp. 25-35
-
-
Schimmer, A.D.1
Welsh, K.2
Pinilla, C.3
-
33
-
-
11144230279
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
-
Sinicrope FA, Penington RC, Tang XM. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin Cancer Res 2004; 10: 8284-92.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8284-8292
-
-
Sinicrope, F.A.1
Penington, R.C.2
Tang, X.M.3
-
34
-
-
0035894946
-
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
-
Takeda K, Smyth MJ, Cretney E et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 2001; 214: 194-200.
-
(2001)
Cell Immunol
, vol.214
, pp. 194-200
-
-
Takeda, K.1
Smyth, M.J.2
Cretney, E.3
-
35
-
-
0037240850
-
Nature's TRAIL-on a path to cancer immunotherapy
-
Smyth MJ, Takeda K, Hayakawa Y, Peschon JJ, van den Brink MR, Yagita H. Nature's TRAIL-on a path to cancer immunotherapy. Immunity 2003; 18: 1-6.
-
(2003)
Immunity
, vol.18
, pp. 1-6
-
-
Smyth, M.J.1
Takeda, K.2
Hayakawa, Y.3
Peschon, J.J.4
van den Brink, M.R.5
Yagita, H.6
-
36
-
-
0033583433
-
Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine
-
Griffith TS, Wiley SR, Kubin MZ, Sedger LM, Maliszewski CR, Fanger NA. Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine. TRAIL. J Exp Med. 1999; 189: 1343-54.
-
(1999)
TRAIL. J Exp Med.
, vol.189
, pp. 1343-1354
-
-
Griffith, T.S.1
Wiley, S.R.2
Kubin, M.Z.3
Sedger, L.M.4
Maliszewski, C.R.5
Fanger, N.A.6
-
37
-
-
0032701696
-
Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Fanger NA, Maliszewski CR, Schooley K, Griffith TS. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Exp Med 1999; 190: 1155-64.
-
(1999)
J Exp Med
, vol.190
, pp. 1155-1164
-
-
Fanger, N.A.1
Maliszewski, C.R.2
Schooley, K.3
Griffith, T.S.4
-
38
-
-
0038339094
-
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
-
Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 2003; 22: 3842-52.
-
(2003)
Oncogene
, vol.22
, pp. 3842-3852
-
-
Ehrhardt, H.1
Fulda, S.2
Schmid, I.3
Hiscott, J.4
Debatin, K.M.5
Jeremias, I.6
-
39
-
-
76949084622
-
TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
-
Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer 2010; 102: 639-44.
-
(2010)
Br J Cancer
, vol.102
, pp. 639-644
-
-
Wu, Y.1
Zhou, B.P.2
-
41
-
-
33845221022
-
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
-
Trauzold A, Siegmund D, Schniewind B et al. TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 2006; 25: 7434-9.
-
(2006)
Oncogene
, vol.25
, pp. 7434-7439
-
-
Trauzold, A.1
Siegmund, D.2
Schniewind, B.3
-
42
-
-
78650340456
-
A first-in-human study of conatumumab in adult patients with advanced solid tumors
-
Herbst RS, Kurzrock R, Hong DS et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res 2010; 16: 5883-91.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5883-5891
-
-
Herbst, R.S.1
Kurzrock, R.2
Hong, D.S.3
-
43
-
-
72449141229
-
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
-
Wakelee HA, Patnaik A, Sikic BI et al. Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann Oncol 2010; 21: 376-81.
-
(2010)
Ann Oncol
, vol.21
, pp. 376-381
-
-
Wakelee, H.A.1
Patnaik, A.2
Sikic, B.I.3
-
44
-
-
47949092316
-
Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors
-
Camidge DR. Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors. Expert Opin Biol Ther. 2008; 8: 1167-76.
-
(2008)
Expert Opin Biol Ther.
, vol.8
, pp. 1167-1176
-
-
Camidge, D.R.1
-
45
-
-
34248187996
-
Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
Tolcher AW, Mita M, Meropol NJ et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 2007; 25: 1390-5.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
-
46
-
-
50349092260
-
A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
-
Hotte SJ, Hirte HW, Chen EX et al. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clin Cancer Res 2008; 14: 3450-5.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3450-3455
-
-
Hotte, S.J.1
Hirte, H.W.2
Chen, E.X.3
|