Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1

Phytomedicine

Volumn 20, Issue 7, 2013, Pages 571-576

  Ramírez Espinosa, Juan José ^a   García Jiménez, Sara ^a   Rios, Maria Yolanda ^b   Medina Franco, José L ^c   López Vallejo, Fabián ^c   Webster, Scott P ^d   Binnie, Margareth ^d   Ibarra Barajas, Maximiliano ^e   Ortiz Andrade, Rolffy ^f   Estrada Soto, Samuel ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^f UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

Author keywords

11 HSD 1; Diabetes; Enzymatic inhibition; Morolic acid; Moronic acid

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ACARBOSE; ANTIDIABETIC AGENT; CHOLESTEROL; GLUCOSE; MOROLIC ACID; MORONIC ACID; SITAGLIPTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; COMPUTER SIMULATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENZYME INHIBITORS; GLUCOSE TOLERANCE TEST; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR DOCKING SIMULATION; OLEANOLIC ACID; RATS; RATS, WISTAR; TRIGLYCERIDES; TRITERPENES;

LORANTHACEAE; PHORADENDRON REICHENBACHIANUM; RATTUS;

EID: 84876416168     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.01.013     Document Type: Article

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