The role of 11β-hydroxysteroid dehydrogenase activity in the metabolic syndrome: Lessons learned from the animal model

European Journal of Endocrinology

Volumn 146, Issue 5, 2002, Pages 603-605

  Dötsch, Jörg ^a   Rascher, Wolfgang ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; LEPTIN; MINERALOCORTICOID; HSD11B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; FEMALE; HUMAN; HYPERCORTISOLISM; HYPERTENSION; LOW BIRTH WEIGHT; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; TRANSGENIC MOUSE; ANIMAL; METABOLIC SYNDROME X; METABOLISM; REVIEW;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; 11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; HUMANS; HYDROXYSTEROID DEHYDROGENASES; METABOLIC SYNDROME X; MICE; MICE, TRANSGENIC;

EID: 0036000324     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1460603     Document Type: Article

References (16)

1. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease
2. Fetal and infant growth and impaired glucose tolerance at age 64
3. Weight-reducing effects of the plasma protein encoded by the obese gene
4. Congenital leptin deficiency is associated with severe early-onset obesity in humans
5. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
6. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
7. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
8. A transgenic model of visceral obesity and the metabolic syndrome
9. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol
10. Effect of glucocorticoid excess on the cortisol/cortisone ratio
11. Cortisol as a mineralocorticoid in human disease
12. Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
13. Tissue-specific dysregulation of cortisol metabolism in human obesity
14. Mini-review: 11beta-hydroxysteroid dehydrogenase type 1 - A tissue-specific amplifier of glucocorticoid action
15. Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia
16. The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: Potential molecular mechanisms underlying the programming of hypertension in utero