Kinetic analysis of the metabotropic glutamate subtype 5 tracer [18 F]FPEB in bolus and bolus-plus-constant-infusion studies in humans

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 4, 2013, Pages 532-541

  Sullivan, Jenna M ^a,b   Lim, Keunpoong ^a   Labaree, David ^a   Lin, Shu Fei ^a   McCarthy, Timothy J ^c   Seibyl, John P ^d   Tamagnan, Gilles ^d   Huang, Yiyun ^a   Carson, Richard E ^a,b   Ding, Yu Shin ^a,e   Morris, Evan D ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale University   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

^e NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

binding potential (BPND); bolus plus constant infusion; glutamate; mGluR5; scan duration; total volume of distribution (VT)

Indexed keywords

3 [18F]FLUORO 5 [(PYRIDINE 3 YL)ETHYNYL]BENZONITRILE; METABOTROPIC RECEPTOR 5; TRACER; UNCLASSIFIED DRUG;

ADULT; ANTERIOR CINGULATE; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CAUDATE NUCLEUS; CEREBELLUM; FEMALE; GLOBUS PALLIDUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; KINETICS; MALE; PRIORITY JOURNAL; WHITE MATTER;

ADULT; FEMALE; HUMANS; KINETICS; MALE; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 84876411974     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.195     Document Type: Article

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