Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203

NeuroImage

Volumn 59, Issue 3, 2012, Pages 2124-2130

  Kimura, Yasuyuki ^a,c   Siméon, Fabrice G ^a   Zoghbi, Sami S ^a   Zhang, Yi ^a   Hatazawa, Jun ^b   Pike, Victor W ^a   Innis, Robert B ^a   Fujita, Masahiro ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

18F SP203; Bolus plus constant infusion; Equilibrium method; Metabotropic glutamate subtype 5 receptor (mGluR5); Positron emission tomography (PET)

Indexed keywords

3 FLUORO 5 [2 [2 (FLUOROMETHYL)THIAZOL 4 YL]ETHYNYL]BENZONITRILE F 18; METABOTROPIC RECEPTOR 5; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTERIAL BLOOD; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISTRIBUTION VOLUME; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG INFUSION; EQUILIBRIUM METHOD; HUMAN; INTERMETHOD COMPARISON; KINETIC METHOD; LIGAND BINDING; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RADIOACTIVITY; STATISTICAL MODEL; VALIDATION STUDY;

ADULT; BRAIN; BRAIN CHEMISTRY; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIGANDS; MALE; MIDDLE AGED; MODELS, STATISTICAL; NITRILES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, METABOTROPIC GLUTAMATE; REPRODUCIBILITY OF RESULTS; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84855444162     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.10.028     Document Type: Article

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