Production of nutritionally desirable fatty acids in seed oil of Indian mustard (Brassica juncea L.) by metabolic engineering

Phytochemistry Reviews

Volumn 11, Issue 2-3, 2012, Pages 197-209

  Bhattacharya, Surajit ^a   Sinha, Saheli ^a,b   Dey, Prabuddha ^a   Das, Natasha ^a   Maiti, Mrinal K ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Edible oil; Fatty acyl ACP thioesterase; Indian mustard (Brassica juncea); Metabolic engineering; Stearoyl ACP desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDIC ACID; DELTA 9 STEAROYL ACP DESATURASE; EDIBLE OIL; ERUCIC ACID; FATTY ACID; FATTY ACYL ACP THIOESTERASE A; FATTY ACYL ACP THIOESTERASE B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LINOLEIC ACID; LINOLENIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OLEIC ACID; OXYGENASE; PALMITIC ACID; STEARIC ACID; THIOL ESTER HYDROLASE; TRANS FATTY ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; VEGETABLE OIL; VERY LONG CHAIN FATTY ACID;

BRASSICA JUNCEA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DISEASE ASSOCIATION; FAT INTAKE; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE SILENCING; HUMAN; INDIA; LIPID COMPOSITION; LIPID STORAGE; LIPOGENESIS; MENTAL HEALTH; METABOLIC ENGINEERING; NONHUMAN; NUTRITION; NUTRITIONAL VALUE; OBESITY; PLANT SEED; PLASTID; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; RISK BENEFIT ANALYSIS; SHELF LIFE;

ANIMALIA; BRASSICA JUNCEA;

EID: 84876409007     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-012-9228-6     Document Type: Review

References (44)

1. Badawy I, Atta B, Ahmed W (1994) Biochemical and toxicological studies on the effect of high and low erucic acid rapeseed oil on rats. Nahrung 38:402-411
2. Balachandran C, Mayamol PN, Thomas S, Sukumar D, Sundaresan A, Arumughan C (2008) An ecofriendly approach to process rice bran for high quality rice bran oil using supercritical carbon dioxide for nutraceutical applications. Bioresour Technol 99:2905-2912
3. Beare-Rogers J, Nera E, Heggtveit H (1971) Cardiac lipid changes in rats fed oils containing long-chain fatty acids. Can Inst Food Technol 4:120-124
4. Buchanan BB, Gruissem W, Jones RL (2000) Biochemistry and molecular biology of plants. American Society of Plant Biologists, USA
5. Cahoon EB (2003) Genetic enhancement of soybean oil for industrial uses: prospects and challenges. AgBioForum 6:11-13
6. Das S, Roscoe TJ, Delseny M, Srivastava PS, Lakshmikumaran M (2003) Cloning and molecular characterization of the Fatty Acid Elongase 1 (FAE 1) gene from high and low erucic acid lines of Brassica campestris and Brassica oleracea. Plant Sci 162:245-250
7. Facciotti MT, Bertain PB, Yuan L (1999) Improved stearate phenotype in transgenic canola expressing a modified acyl-acyl carrier protein thioesterase. Nat Biotechnol 17:593-597
8. Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T (1998) Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA study, protocol 1. Arterioscl Thomb Vasc Biol 18:441-449
9. Han J, Lühs W, Sonntag K, Zähinger U, Borchardt DS, Wolter FP, Heinz E, Frentzen M (2001) Functional characterization of β-ketoacyl-CoA synthase genes from Brassica napus L. Plant Mol Biol 46:229-239
10. Harwood JL (1996) Recent advances in the biosynthesis of plant fattyacids. Biochim Biophys Acta 1301:7-56
11. Hawkins DJ, Kridl JC (1998) Characterization of acyl ACP thioesterase of mangosteen (Garcinia mangostana) seed and high level of stearate production in transgenic canola. Plant J 13:743-752
12. Hayes KC, Khosla P (2007) The complex interplay of palm oil fatty acids on blood lipids. Eur J Lipid Sci Tech 109:453-464
13. Hitz WD, Mauvis CJ, Ripp KG, Reiter RJ (1995) The use of cloned rapeseed genes for the cytoplasmic fatty acid desaturases and the plastid acyl-ACP thioesterases to alter relative levels of polyunsaturated and saturated fatty acids in rapeseed oil. In: Proceedings of 9th international rapeseed congress: rapeseed today and tomorrow. Cambridge, UK, pp 470-472
14. Hung S, Umemura T, Yamashiro S, Slinger SJ (1977) The effects of original and randomized rapeseed oils containing high or very low levels of erucic acid on cardiac lipids and myocardial lesions in rats. Lipids 12:215-221
15. Jha JK, Maiti MK, Bhattacharjee A, Basu A, Sen PC, Sen SK (2006) Cloning and functional expression of an acyl-ACP thioesterase FatB type from Diploknema (Madhuca butyracea) seeds in Escherichia coli. Plant Physiol Biochem 44:645-655
16. Jha JK, Sinha S, Maiti MK, Basu A, Mukhopadhyay UK, Sen SK (2007) Functional expression of an acyl carrier protein (ACP) from Azospirillum brasilense alters fatty acid profiles in Escherichia coli and Brassica juncea. Plant Physiol Biochem 45:490-500
17. Kanrar S, Venkateswari J, Dureja P, Kirti PB, Chopra VL (2006) Modification of erucic acid content in Indian mustard (Brassica juncea) by up-regulation and down-regulation of the Brassica juncea FATTY ACID ELONGATION1 (BjFAE1) gene. Plant Cell Rep 25:148-155
18. Katavic V, Friesen W, Barton DL, Gossen KK, Giblin EM, Luciw T, An J, Zou J, MacKenzie SL, Keller WA, Males D, Taylor DC (2001) Improving erucic acid content in rapeseed through biotechnology: what can the Arabidopsis FAE1 and the yeast SLC1-1 genes contribute? Crop Sci 41:739-747
19. Kaushik N, Agnihotri A (2000) GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. Biochem Soc Trans 28:581-583
20. Knutzon DS, Thompson GA, Radke SE, Johnson WB, Knauf VC, Kridl JC (1992) Modification of Brassica seed oil by antisense expression of a stearoyl-acyl carrier protein desaturase gene. Proc Natl Acad Sci 89:2624-2628
21. Kumar PR, Singh R, Misra AK (2004) Rapeseed-mustard. In: Dhillon BS, Tyagi RK, Saxena S, Agrawal A (eds) Plant genetic resources: oilseed and cash crops. Narosa Publishing House, New Delhi, pp 20-44
22. Lassner MW, Lardizabal K, Metz JG (1996) A jojoba β ketoacyl-CoA synthase cDNA complements the canola fatty acid elongation mutation in transgenic plants. Plant Cell 8:281-292
23. Loader NM, Woolner EM, Hellyer A, Salbas AR, Safford R (1993) Isolation and characterization of two Brassica napus embryo acyl-ACP thioesterase cDNA clones. Plant Mol Biol 23:769-778
24. Mattson FH (1989) A changing role for dietary monounsaturated fatty acids. J Am Diet Assoc 89:387-391
25. Mattson FH, Grundy SM (1985) Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res 26:194-202
26. Mensink and Katan (1989) Effect of a diet enriched with monounsaturated fatty acids on levels of LDL- and HDL-cholesterol in healthy women and men. N Engl J Med 321:436-441
27. Mietkiewska E, Brost JM, Giblin EM, Barton DL, Taylor DC (2007) Cloning and functional characterization of the fatty acid elongase 1 (FAE1) gene from high erucic Crambe abyssinica cv. Prophet. Plant Biotechnol J 5:636-645
28. Millar AA, Kunst L (1997) Very long chain fatty acid biosynthesis is controlled through the expression and specificity of the condensing enzyme. Plant J 12(1):121-131
29. Muller H, Lindman AS, Brantsaeter AL, Pedersen JI (2003) The serum LDL/HDL cholesterol ratio is influenced more favorably by exchanging saturated with unsaturated fat than by reducing saturated fat in the diet of women. J Nutr 133:78-83
30. Nagaraj G (1996) Composition and quality of oil seeds. In: Nizam J, Farook SA, Khan IA (eds) Genetic improvement of oilseed crops. Ukaaz Publications, Hyderabad, India
31. Pathak MK, Bhattacharjee A, Ghosh D, Ghosh S (2004) Acyl-acyl carrier protein (ACP)-thioesterase from developing seeds of Brassica campestris cv. B-54 (Agrani). Plant Sci 166:191-198
32. Pérez-Vich B, Knapp SJ, Leon AJ, Fernández-Martínez JM, Berry ST (2004) Mapping minor QTL for increased stearic acid content in sunflower seed oil. Mol Breed 13:313-322
33. Purkrtova Z, Jolivet P, Miquel M, Chardot T (2008) Structure and function of seed oleosins and caleosin. C R Biologies 331:746-754
34. Schmid KM, Ohlrogge JB (2002) Lipid metabolism in plants. In: Vance DE, Vance JE (eds) Biochemistry of lipids, lipoproteins and membrane, 4th edn. Elsevier Science BV, Amsterdam
35. Simoni RD, Criddle RS, Stumpf PK (1967) Fat metabolism in higher plants. XXXI. Purification and properties of plant and bacterial acyl carrier proteins. J Biol Chem 242:573-581
36. Simopoulos AP (2000) Symposium: role of poultry products in enriching the human diet with n-3 PUFA. Poult Sci 79:961-970
37. Sinha S, Jha JK, Maiti MK, Basu A, Mukhopadhyay UK, Sen SK (2007) Metabolic engineering of fatty acid biosynthesis in Indian mustard (Brassica juncea) improves nutritional quality of seed oil. Plant Biotechnol Rep 1:185-197
38. Sircar S, Kansra U (1998) Choice of cooking oils-myths and realities. J Indian Med Assoc 96:304-307
39. Somerville C, Browse J, Jaworski JG, Ohlrogge JB (2000) Lipids. In Buchanan BB, Gruissem W, Jones R (eds) Biochemistry and molecular biology of plants. Am Soc Plant Physiologists, Rockville, MD, pp 456-527
40. Sonnad JS, Raveendaran N, Ajjan N, Selvaraj KN (2011) Growth analysis of oilseed crops in India during pre and post - WTO periods. Karnataka J Agric Sci 24(2):184-187
41. Tian B, Wei F, Shu H, Zhang Q, Zang X, Lian Y (2011) Decreasing erucic acid level by RNAi-mediated silencing of fatty acid elongase 1 (BnFAE1.1) in rapeseeds (Brassica napus L.) A. Afr J Biotechnol 61(10):13194-13201
42. Topfer R, Martini N, Schell J (1995) Modification of plant lipid synthesis. Science 268:681-686
43. Wijendran V, Hayes KC (2004) Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr 24:597-615
44. Zarhloul MK, Stoll C, Luhs W, Syring-Ehemann A, Hausmann L, Topfer R, Friedt W (2006) Breeding high-stearic oilseed rape (Brassica napus) with high- and low-erucic background using optimised promoter-gene constructs. Mol Breed 18(3):241-251