In silico, in vitro, and in vivo studies indicate the potential use of bolaamphiphiles for therapeutic siRNAs delivery

Molecular Therapy Nucleic Acids

Volumn 2, Issue , 2013, Pages e80-

  Kim, Taejin ^a   Afonin, Kirill A ^a   Viard, Mathias ^a,b   Koyfman, Alexey Y ^c   Sparks, Selene ^a   Heldman, Eliahu ^b,d   Grinberg, Sarina ^d   Linder, Charles ^d   Blumenthal, Robert P ^a   Shapiro, Bruce A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Bolaamphiphiles; Cryo EM; FRET; Molecular dynamics simulations; Poly cationic micelles; RNA based therapeutics; SiRNA delivery; Specific gene silencing

Indexed keywords

ACETYLCHOLINE; ALKYL GROUP; AMPHOPHILE; BOLAAMPHIPHILE; DRUG CARRIER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CELL CULTURE; CHEMICAL STRUCTURE; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; DRUG RELEASE; DRUG UPTAKE; GENE SILENCING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RNA BINDING; STATIC ELECTRICITY;

EID: 84876407085     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.5     Document Type: Article

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