메뉴 건너뛰기




Volumn 19, Issue 14, 2013, Pages 2262-2269

Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells

Author keywords

3 hydroxy 3 methylglutharylcoenzyme A reductase; Hepatitis B virus; Lowdensity lipoprotein receptor; Toll like receptors

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 84876387922     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i14.2262     Document Type: Article
Times cited : (38)

References (30)
  • 1
    • 80051676859 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: Results of systematic reviews
    • [PMID: 21802134 DOI: 10.1016/S0140-6736(11)61097-0]
    • Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, Degenhardt L. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet 2011; 378: 571-583 [PMID: 21802134 DOI: 10.1016/S0140-6736(11)61097-0]
    • (2011) Lancet , vol.378 , pp. 571-583
    • Nelson, P.K.1    Mathers, B.M.2    Cowie, B.3    Hagan, H.4    des Jarlais, D.5    Horyniak, D.6    Degenhardt, L.7
  • 3
    • 34547102988 scopus 로고    scopus 로고
    • Impact of non-alcoholic fatty liver disease on chronic hepatitis B
    • [PMID: 17498244 DOI: 10.1111/j.1478-3231.2007.01482.x]
    • Bondini S, Kallman J, Wheeler A, Prakash S, Gramlich T, Jondle DM, Younossi ZM. Impact of non-alcoholic fatty liver disease on chronic hepatitis B. Liver Int 2007; 27: 607-611 [PMID: 17498244 DOI: 10.1111/j.1478-3231.2007.01482.x]
    • (2007) Liver Int , vol.27 , pp. 607-611
    • Bondini, S.1    Kallman, J.2    Wheeler, A.3    Prakash, S.4    Gramlich, T.5    Jondle, D.M.6    Younossi, Z.M.7
  • 4
    • 34247636128 scopus 로고    scopus 로고
    • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C
    • [PMID: 17335930 DOI: 10.1016/j.jhep.2007.01.021]
    • Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C. Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C. J Hepatol 2007; 46: 1126-1132 [PMID: 17335930 DOI: 10.1016/j.jhep.2007.01.021]
    • (2007) J Hepatol , vol.46 , pp. 1126-1132
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Arcaro, G.5    Day, C.6
  • 5
    • 58149291663 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha
    • [PMID: 18782084 DOI: 10.1042/BJ20081336]
    • Kim K, Kim KH, Kim HH, Cheong J. Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochem J 2008; 416: 219-230 [PMID: 18782084 DOI: 10.1042/BJ20081336]
    • (2008) Biochem J , vol.416 , pp. 219-230
    • Kim, K.1    Kim, K.H.2    Kim, H.H.3    Cheong, J.4
  • 8
    • 0141606713 scopus 로고    scopus 로고
    • Abnormal immunity and gene mutation in patients with severe hepatitis-B
    • [PMID: 12970895]
    • Wang JY, Liu P. Abnormal immunity and gene mutation in patients with severe hepatitis-B. World J Gastroenterol 2003; 9: 2009-2011 [PMID: 12970895]
    • (2003) World J Gastroenterol , vol.9 , pp. 2009-2011
    • Wang, J.Y.1    Liu, P.2
  • 9
    • 84866739329 scopus 로고    scopus 로고
    • Oxidized LDLs inhibit TLR-induced IL-10 production by monocytes: A new aspect of pathogen-accelerated atherosclerosis
    • [PMID: 22556042 DOI: 10.1007/ s110753-012-9472-3]
    • Bzowska M, Nogieć A, Skrzeczyńska-Moncznik J, Mickowska B, Guzik K, Pryjma J. Oxidized LDLs inhibit TLR-induced IL-10 production by monocytes: a new aspect of pathogen-accelerated atherosclerosis. Inflammation 2012; 35: 1567-1584 [PMID: 22556042 DOI: 10.1007/ s110753-012-9472-3]
    • (2012) Inflammation , vol.35 , pp. 1567-1584
    • Bzowska, M.1    Nogieć, A.2    Skrzeczyńska-Moncznik, J.3    Mickowska, B.4    Guzik, K.5    Pryjma, J.6
  • 10
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • [PMID: 15229469]
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511 [PMID: 15229469]
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 11
    • 48649109740 scopus 로고    scopus 로고
    • The significance of Toll-like receptor 4 (TLR4) expression in patients with chronic hepatitis B
    • [PMID: 18544275]
    • Wei XQ, Guo YW, Liu JJ, Wen ZF, Yang SJ, Yao JL. The significance of Toll-like receptor 4 (TLR4) expression in patients with chronic hepatitis B. Clin Invest Med 2008; 31: E123-E130 [PMID: 18544275]
    • (2008) Clin Invest Med , vol.31
    • Wei, X.Q.1    Guo, Y.W.2    Liu, J.J.3    Wen, Z.F.4    Yang, S.J.5    Yao, J.L.6
  • 12
    • 49149128080 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • [PMID: 18565796 DOI: 10.1016/ j.clim.2008.04.006]
    • Chen Z, Cheng Y, Xu Y, Liao J, Zhang X, Hu Y, Zhang Q, Wang J, Zhang Z, Shen F, Yuan Z. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008; 128: 400-408 [PMID: 18565796 DOI: 10.1016/ j.clim.2008.04.006]
    • (2008) Clin Immunol , vol.128 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3    Liao, J.4    Zhang, X.5    Hu, Y.6    Zhang, Q.7    Wang, J.8    Zhang, Z.9    Shen, F.10    Yuan, Z.11
  • 13
    • 80052365243 scopus 로고    scopus 로고
    • Role of Toll-like receptors in liver health and disease
    • [PMID: 21797822 DOI: 10.1042/CS20110065]
    • Broering R, Lu M, Schlaak JF. Role of Toll-like receptors in liver health and disease. Clin Sci (Lond) 2011; 121: 415-426 [PMID: 21797822 DOI: 10.1042/CS20110065]
    • (2011) Clin Sci (Lond) , vol.121 , pp. 415-426
    • Broering, R.1    Lu, M.2    Schlaak, J.F.3
  • 14
    • 73949089928 scopus 로고    scopus 로고
    • Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infection
    • [PMID: 19945134 DOI: 10.1016/ j.virol.2009.11.007]
    • Zhang Y, Lian JQ, Huang CX, Wang JP, Wei X, Nan XP, Yu HT, Jiang LL, Wang XQ, Zhuang Y, Li XH, Li Y, Wang PZ, Robek MD, Bai XF. Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infection. Virology 2010; 397: 34-42 [PMID: 19945134 DOI: 10.1016/ j.virol.2009.11.007]
    • (2010) Virology , vol.397 , pp. 34-42
    • Zhang, Y.1    Lian, J.Q.2    Huang, C.X.3    Wang, J.P.4    Wei, X.5    Nan, X.P.6    Yu, H.T.7    Jiang, L.L.8    Wang, X.Q.9    Zhuang, Y.10    Li, X.H.11    Li, Y.12    Wang, P.Z.13    Robek, M.D.14    Bai, X.F.15
  • 15
    • 78349247954 scopus 로고    scopus 로고
    • Aspirin increases apolipoprotein-A-Imediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1
    • [PMID: 21088444 DOI: 10.1159/000321727]
    • Wang YH, Chen YF, Chen SR, Chen X, Chen JW, Shen XY, Mou YG, Liu PQ. Aspirin increases apolipoprotein-A-Imediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1. Pharmacology 2010; 86: 320-326 [PMID: 21088444 DOI: 10.1159/000321727]
    • (2010) Pharmacology , vol.86 , pp. 320-326
    • Wang, Y.H.1    Chen, Y.F.2    Chen, S.R.3    Chen, X.4    Chen, J.W.5    Shen, X.Y.6    Mou, Y.G.7    Liu, P.Q.8
  • 16
    • 21344446513 scopus 로고    scopus 로고
    • Steatosis: Co-factor in other liver diseases
    • [PMID: 15962320]
    • Powell EE, Jonsson JR, Clouston AD. Steatosis: co-factor in other liver diseases. Hepatology 2005; 42: 5-13 [PMID: 15962320]
    • (2005) Hepatology , vol.42 , pp. 5-13
    • Powell, E.E.1    Jonsson, J.R.2    Clouston, A.D.3
  • 17
    • 78650780107 scopus 로고    scopus 로고
    • Oxidative stress and antioxidants in hepatic pathogenesis
    • [PMID: 21182217 DOI: 10.3748/wjg.v16. i48.6035]
    • Ha HL, Shin HJ, Feitelson MA, Yu DY. Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol 2010; 16: 6035-6043 [PMID: 21182217 DOI: 10.3748/wjg.v16. i48.6035]
    • (2010) World J Gastroenterol , vol.16 , pp. 6035-6043
    • Ha, H.L.1    Shin, H.J.2    Feitelson, M.A.3    Yu, D.Y.4
  • 18
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • [PMID: 15254578]
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114: 147-152 [PMID: 15254578]
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 19
    • 84862156455 scopus 로고    scopus 로고
    • The impact of fibrosis and steatosis on early viral kinetics in HCV genotype 1-infected patients treated with Peg-IFN-alfa-2a and ribavirin
    • [PMID: 22676361 DOI: 10.1111/ j.1365-2893.2011.01569]
    • Guedj H, Guedj J, Negro F, Lagging M, Westin J, Bochud PY, Bibert S, Neumann AU. The impact of fibrosis and steatosis on early viral kinetics in HCV genotype 1-infected patients treated with Peg-IFN-alfa-2a and ribavirin. J Viral Hepat 2012; 19: 488-496 [PMID: 22676361 DOI: 10.1111/ j.1365-2893.2011.01569]
    • (2012) J Viral Hepat , vol.19 , pp. 488-496
    • Guedj, H.1    Guedj, J.2    Negro, F.3    Lagging, M.4    Westin, J.5    Bochud, P.Y.6    Bibert, S.7    Neumann, A.U.8
  • 20
    • 84872138890 scopus 로고    scopus 로고
    • Hepatitis C virus diversity and hepatic steatosis
    • [PMID: 23301542 DOI: 10.1111/jvh.12035]
    • Roingeard P. Hepatitis C virus diversity and hepatic steatosis. J Viral Hepat 2013; 20: 77-84 [PMID: 23301542 DOI: 10.1111/jvh.12035]
    • (2013) J Viral Hepat , vol.20 , pp. 77-84
    • Roingeard, P.1
  • 21
    • 84859336624 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis
    • [PMID: 22461740]
    • Go GW, Mani A. Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis. Yale J Biol Med 2012; 85: 19-28 [PMID: 22461740]
    • (2012) Yale J Biol Med , vol.85 , pp. 19-28
    • Go, G.W.1    Mani, A.2
  • 22
    • 0023937458 scopus 로고
    • Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice
    • [PMID: 3344433]
    • Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE. Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science 1988; 239: 1277-1281 [PMID: 3344433]
    • (1988) Science , vol.239 , pp. 1277-1281
    • Hofmann, S.L.1    Russell, D.W.2    Brown, M.S.3    Goldstein, J.L.4    Hammer, R.E.5
  • 23
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • [PMID: 1967820]
    • Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425-430 [PMID: 1967820]
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 24
    • 0022536417 scopus 로고
    • Hydroxymethylglutaryl-CoA reductase--the rate-limiting enzyme of cholesterol biosynthesis. A report of a meeting held at Nijenrode Castle, Breukelen, The Netherlands, August 24, 1985
    • [PMID: 3519281]
    • Geelen MJ, Gibson DM, Rodwell VW. Hydroxymethylglutaryl-CoA reductase--the rate-limiting enzyme of cholesterol biosynthesis. A report of a meeting held at Nijenrode Castle, Breukelen, The Netherlands, August 24, 1985. FEBS Lett 1986; 201: 183-186 [PMID: 3519281]
    • (1986) FEBS Lett , vol.201 , pp. 183-186
    • Geelen, M.J.1    Gibson, D.M.2    Rodwell, V.W.3
  • 25
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • [PMID: 18559695 DOI: 10.1161/CIRCULATIONAHA.108.773267]
    • Medina MW, Gao F, Ruan W, Rotter JI, Krauss RM. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation 2008; 118: 355-362 [PMID: 18559695 DOI: 10.1161/CIRCULATIONAHA.108.773267]
    • (2008) Circulation , vol.118 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3    Rotter, J.I.4    Krauss, R.M.5
  • 26
    • 0027679677 scopus 로고
    • Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection
    • [PMID: 8406351]
    • Mason A, Wick M, White H, Perrillo R. Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection. Hepatology 1993; 18: 781-789 [PMID: 8406351]
    • (1993) Hepatology , vol.18 , pp. 781-789
    • Mason, A.1    Wick, M.2    White, H.3    Perrillo, R.4
  • 27
    • 0032756265 scopus 로고    scopus 로고
    • Virus-associated vasculitides
    • [PMID: 10461469]
    • Guillevin L. Virus-associated vasculitides. Rheumatology (Oxford) 1999; 38: 588-590 [PMID: 10461469]
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 588-590
    • Guillevin, L.1
  • 29
    • 70350112138 scopus 로고    scopus 로고
    • Correlation of circulating TLR2/4 expression with CD3+/4+/8+ T cells and Treg cells in HBV-related liver cirrhosis
    • [PMID: 19811087 DOI: 10.1089/ vim.2009.0039]
    • Lian JQ, Wang XQ, Zhang Y, Huang CX, Bai XF. Correlation of circulating TLR2/4 expression with CD3+/4+/8+ T cells and Treg cells in HBV-related liver cirrhosis. Viral Immunol 2009; 22: 301-308 [PMID: 19811087 DOI: 10.1089/ vim.2009.0039]
    • (2009) Viral Immunol , vol.22 , pp. 301-308
    • Lian, J.Q.1    Wang, X.Q.2    Zhang, Y.3    Huang, C.X.4    Bai, X.F.5
  • 30
    • 84873147166 scopus 로고    scopus 로고
    • The role of the toll-like receptor TLR4 in hepatitis B virus-associated glomerulonephritis
    • [PMID: 23076739]
    • Zhou Y, Zhu N, Wang X, Wang L, Gu LJ, Yuan WJ. The role of the toll-like receptor TLR4 in hepatitis B virus-associated glomerulonephritis. Arch Virol 2013; 158: 425-433 [PMID: 23076739]
    • (2013) Arch Virol , vol.158 , pp. 425-433
    • Zhou, Y.1    Zhu, N.2    Wang, X.3    Wang, L.4    Gu, L.J.5    Yuan, W.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.