-
1
-
-
84856608720
-
WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
-
Antenor-Dorsey J.A., O'Malley K.L. WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity. Molecular Neurodegeneration 2012, 7:5.
-
(2012)
Molecular Neurodegeneration
, vol.7
, pp. 5
-
-
Antenor-Dorsey, J.A.1
O'Malley, K.L.2
-
2
-
-
78650924736
-
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
-
Bernstein A.I., Garrison S.P., Zambetti G.P., O'Malley K.L. 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Molecular Neurodegeneration 2011, 6:2.
-
(2011)
Molecular Neurodegeneration
, vol.6
, pp. 2
-
-
Bernstein, A.I.1
Garrison, S.P.2
Zambetti, G.P.3
O'Malley, K.L.4
-
3
-
-
0034993599
-
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
-
Blum D., Torch S., Lambeng N., Nissou M., Benabid A.L., Sadoul R., Verna J.M. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Progress in Neurobiology 2001, 65:135-172.
-
(2001)
Progress in Neurobiology
, vol.65
, pp. 135-172
-
-
Blum, D.1
Torch, S.2
Lambeng, N.3
Nissou, M.4
Benabid, A.L.5
Sadoul, R.6
Verna, J.M.7
-
4
-
-
0141741347
-
Parkinson's disease: mechanisms and models
-
Dauer W., Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003, 39:889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
5
-
-
0036829557
-
P53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
-
Duan W., Zhu X., Ladenheim B., Yu Q.S., Guo Z., Oyler J., Cutler R.G., Cadet J.L., Greig N.H., Mattson M.P. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Annals of Neurology 2002, 52:597-606.
-
(2002)
Annals of Neurology
, vol.52
, pp. 597-606
-
-
Duan, W.1
Zhu, X.2
Ladenheim, B.3
Yu, Q.S.4
Guo, Z.5
Oyler, J.6
Cutler, R.G.7
Cadet, J.L.8
Greig, N.H.9
Mattson, M.P.10
-
6
-
-
79953148080
-
The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death
-
Egawa N., Yamamoto K., Inoue H., Hikawa R., Nishi K., Mori K., Takahashi R. The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death. Journal of Biological Chemistry 2011, 286:7947-7957.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 7947-7957
-
-
Egawa, N.1
Yamamoto, K.2
Inoue, H.3
Hikawa, R.4
Nishi, K.5
Mori, K.6
Takahashi, R.7
-
8
-
-
2942718697
-
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis
-
Hartman M.G., Lu D., Kim M.L., Kociba G.J., Shukri T., Buteau J., Wang X., Frankel W.L., Guttridge D., Prentki M., Grey S.T., Ron D., Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Molecular and Cellular Biology 2004, 24:5721-5732.
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 5721-5732
-
-
Hartman, M.G.1
Lu, D.2
Kim, M.L.3
Kociba, G.J.4
Shukri, T.5
Buteau, J.6
Wang, X.7
Frankel, W.L.8
Guttridge, D.9
Prentki, M.10
Grey, S.T.11
Ron, D.12
Hai, T.13
-
9
-
-
26844532113
-
Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
-
Hasbani D.M., Perez F.A., Palmiter R.D., O'Malley K.L. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. Journal of Neuroscience 2005, 25:9428-9433.
-
(2005)
Journal of Neuroscience
, vol.25
, pp. 9428-9433
-
-
Hasbani, D.M.1
Perez, F.A.2
Palmiter, R.D.3
O'Malley, K.L.4
-
10
-
-
84868135034
-
ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease
-
Hashida K., Kitao Y., Sudo H., Awa Y., Maeda S., Mori K., Takahashi R., Iinuma M., Hori O. ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease. PLoS ONE 2012, 7:e47950.
-
(2012)
PLoS ONE
, vol.7
-
-
Hashida, K.1
Kitao, Y.2
Sudo, H.3
Awa, Y.4
Maeda, S.5
Mori, K.6
Takahashi, R.7
Iinuma, M.8
Hori, O.9
-
11
-
-
37849026130
-
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
-
Hetz C., Glimcher L. The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. Trends in Cell Biology 2008, 18:38-44.
-
(2008)
Trends in Cell Biology
, vol.18
, pp. 38-44
-
-
Hetz, C.1
Glimcher, L.2
-
12
-
-
0038143287
-
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
-
Holtz W.A., O'Malley K.L. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. Journal of Biological Chemistry 2003, 278:19367-19377.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 19367-19377
-
-
Holtz, W.A.1
O'Malley, K.L.2
-
13
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks T., Remington L., Williams B.O., Schmitt E.M., Halachmi S., Bronson R.T., Weinberg R.A. Tumor spectrum analysis in p53-mutant mice. Current Biology 1994, 4:1-7.
-
(1994)
Current Biology
, vol.4
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
Schmitt, E.M.4
Halachmi, S.5
Bronson, R.T.6
Weinberg, R.A.7
-
14
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers J.R., Parganas E., Lee Y., Yang C., Wang J., Brennan J., MacLean K.H., Han J., Chittenden T., Ihle J.N., McKinnon P.J., Cleveland J.L., Zambetti G.P. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003, 4:321-328.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
Yang, C.4
Wang, J.5
Brennan, J.6
MacLean, K.H.7
Han, J.8
Chittenden, T.9
Ihle, J.N.10
McKinnon, P.J.11
Cleveland, J.L.12
Zambetti, G.P.13
-
15
-
-
1642458354
-
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response
-
Jiang H.Y., Wek S.A., McGrath B.C., Lu D., Hai T., Harding H.P., Wang X., Ron D., Cavener D.R., Wek R.C. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Molecular and Cellular Biology 2004, 24:1365-1377.
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 1365-1377
-
-
Jiang, H.Y.1
Wek, S.A.2
McGrath, B.C.3
Lu, D.4
Hai, T.5
Harding, H.P.6
Wang, X.7
Ron, D.8
Cavener, D.R.9
Wek, R.C.10
-
16
-
-
58149393845
-
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice
-
Karunakaran S., Saeed U., Mishra M., Valli R.K., Joshi S.D., Meka D.P., Seth P., Ravindranath V. Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Journal of Neuroscience 2008, 28:12500-12509.
-
(2008)
Journal of Neuroscience
, vol.28
, pp. 12500-12509
-
-
Karunakaran, S.1
Saeed, U.2
Mishra, M.3
Valli, R.K.4
Joshi, S.D.5
Meka, D.P.6
Seth, P.7
Ravindranath, V.8
-
17
-
-
79956299326
-
The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons
-
Kim-Han J.S., Antenor-Dorsey J.A., O'Malley K.L. The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. Journal of Neuroscience 2011, 31:7212-7221.
-
(2011)
Journal of Neuroscience
, vol.31
, pp. 7212-7221
-
-
Kim-Han, J.S.1
Antenor-Dorsey, J.A.2
O'Malley, K.L.3
-
18
-
-
79960834471
-
Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP(+)) model of Parkinson's disease
-
Kook Y.H., Ka M., Um M. Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP(+)) model of Parkinson's disease. Biochemical and Biophysical Research Communications 2011, 411:370-374.
-
(2011)
Biochemical and Biophysical Research Communications
, vol.411
, pp. 370-374
-
-
Kook, Y.H.1
Ka, M.2
Um, M.3
-
19
-
-
0033557640
-
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
-
Lotharius J., Dugan L.L., O'Malley K.L. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. Journal of Neuroscience 1999, 19:1284-1293.
-
(1999)
Journal of Neuroscience
, vol.19
, pp. 1284-1293
-
-
Lotharius, J.1
Dugan, L.L.2
O'Malley, K.L.3
-
21
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
-
Malhotra J.D., Kaufman R.J. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxidants and Redox Signalling 2007, 9:2277-2293.
-
(2007)
Antioxidants and Redox Signalling
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
22
-
-
0034571235
-
DNA damage in brain mitochondria caused by aging and MPTP treatment
-
Mandavilli B.S., Ali S.F., Van Houten B. DNA damage in brain mitochondria caused by aging and MPTP treatment. Brain Research 2000, 885:45-52.
-
(2000)
Brain Research
, vol.885
, pp. 45-52
-
-
Mandavilli, B.S.1
Ali, S.F.2
Van Houten, B.3
-
23
-
-
0036788183
-
A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism
-
Mandir A.S., Simbulan-Rosenthal C.M., Poitras M.F., Lumpkin J.R., Dawson V.L., Smulson M.E., Dawson T.M. A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism. Journal of Neurochemistry 2002, 83:186-192.
-
(2002)
Journal of Neurochemistry
, vol.83
, pp. 186-192
-
-
Mandir, A.S.1
Simbulan-Rosenthal, C.M.2
Poitras, M.F.3
Lumpkin, J.R.4
Dawson, V.L.5
Smulson, M.E.6
Dawson, T.M.7
-
24
-
-
0021137683
-
Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
-
Markey S.P., Johannessen J.N., Chiueh C.C., Burns R.S., Herkenham M.A. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 1984, 311:464-467.
-
(1984)
Nature
, vol.311
, pp. 464-467
-
-
Markey, S.P.1
Johannessen, J.N.2
Chiueh, C.C.3
Burns, R.S.4
Herkenham, M.A.5
-
25
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K., Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Molecular Cell 2001, 7:683-694.
-
(2001)
Molecular Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
26
-
-
0042334593
-
Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons
-
O'Malley K.L., Liu J., Lotharius J., Holtz W. Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons. Neurobiology of Disease 2003, 14:43-51.
-
(2003)
Neurobiology of Disease
, vol.14
, pp. 43-51
-
-
O'Malley, K.L.1
Liu, J.2
Lotharius, J.3
Holtz, W.4
-
27
-
-
0042477717
-
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
-
Reimertz C., Kogel D., Rami A., Chittenden T., Prehn J.H. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Journal of Cell Biology 2003, 162:587-597.
-
(2003)
Journal of Cell Biology
, vol.162
, pp. 587-597
-
-
Reimertz, C.1
Kogel, D.2
Rami, A.3
Chittenden, T.4
Prehn, J.H.5
-
28
-
-
0037114971
-
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease
-
Ryu E.J., Harding H.P., Angelastro J.M., Vitolo O.V., Ron D., Greene L.A. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. Journal of Neuroscience 2002, 22:10690-10698.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 10690-10698
-
-
Ryu, E.J.1
Harding, H.P.2
Angelastro, J.M.3
Vitolo, O.V.4
Ron, D.5
Greene, L.A.6
-
29
-
-
63349104307
-
Protective effect against Parkinson's disease-related insults through the activation of XBP1
-
Sado M., Yamasaki Y., Iwanaga T., Onaka Y., Ibuki T., Nishihara S., Mizuguchi H., Momota H., Kishibuchi R., Hashimoto T., Wada D., Kitagawa H., Watanabe T.K. Protective effect against Parkinson's disease-related insults through the activation of XBP1. Brain Research 2009, 1257:16-24.
-
(2009)
Brain Research
, vol.1257
, pp. 16-24
-
-
Sado, M.1
Yamasaki, Y.2
Iwanaga, T.3
Onaka, Y.4
Ibuki, T.5
Nishihara, S.6
Mizuguchi, H.7
Momota, H.8
Kishibuchi, R.9
Hashimoto, T.10
Wada, D.11
Kitagawa, H.12
Watanabe, T.K.13
-
30
-
-
18044364423
-
Pathological proteins in Parkinson's disease: focus on the proteasome
-
Snyder H., Wolozin B. Pathological proteins in Parkinson's disease: focus on the proteasome. Journal of Molecular Neuroscience 2004, 24:425-442.
-
(2004)
Journal of Molecular Neuroscience
, vol.24
, pp. 425-442
-
-
Snyder, H.1
Wolozin, B.2
-
31
-
-
0034108225
-
Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata
-
Staal R.G., Sonsalla P.K. Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata. Journal of Pharmacology and Experimental Therapeutics 2000, 293:336-342.
-
(2000)
Journal of Pharmacology and Experimental Therapeutics
, vol.293
, pp. 336-342
-
-
Staal, R.G.1
Sonsalla, P.K.2
-
32
-
-
84873287971
-
ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin
-
Sun X., Liu J., Crary J.F., Malagelada C., Sulzer D., Greene L.A., Levy O.A. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. Journal of Neuroscience 2013, 33:2398-2407.
-
(2013)
Journal of Neuroscience
, vol.33
, pp. 2398-2407
-
-
Sun, X.1
Liu, J.2
Crary, J.F.3
Malagelada, C.4
Sulzer, D.5
Greene, L.A.6
Levy, O.A.7
-
33
-
-
0030249597
-
Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity
-
Trimmer P.A., Smith T.S., Jung A.B., Bennett J.P. Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. Neurodegeneration 1996, 5:233-239.
-
(1996)
Neurodegeneration
, vol.5
, pp. 233-239
-
-
Trimmer, P.A.1
Smith, T.S.2
Jung, A.B.3
Bennett, J.P.4
-
34
-
-
0035956874
-
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
-
Vila M., Jackson-Lewis V., Vukosavic S., Djaldetti R., Liberatore G., Offen D., Korsmeyer S.J., Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:2837-2842.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 2837-2842
-
-
Vila, M.1
Jackson-Lewis, V.2
Vukosavic, S.3
Djaldetti, R.4
Liberatore, G.5
Offen, D.6
Korsmeyer, S.J.7
Przedborski, S.8
-
35
-
-
3142523288
-
Genetic clues to the pathogenesis of Parkinson's disease
-
Vila M., Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nature Medicine 2004, 10(Suppl.):S58-S62.
-
(2004)
Nature Medicine
, vol.10
, Issue.SUPPL.
-
-
Vila, M.1
Przedborski, S.2
-
36
-
-
0037713529
-
Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease
-
Wang H., Shimoji M., Yu S.W., Dawson T.M., Dawson V.L. Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease. Annals of the New York Academy of Sciences 2003, 991:132-139.
-
(2003)
Annals of the New York Academy of Sciences
, vol.991
, pp. 132-139
-
-
Wang, H.1
Shimoji, M.2
Yu, S.W.3
Dawson, T.M.4
Dawson, V.L.5
-
37
-
-
33645156429
-
From acute ER stress to physiological roles of the Unfolded Protein Response
-
Wu J., Kaufman R.J. From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death and Differentiation 2006, 13:374-384.
-
(2006)
Cell Death and Differentiation
, vol.13
, pp. 374-384
-
-
Wu, J.1
Kaufman, R.J.2
-
38
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J., Zhang L., Hwang P.M., Kinzler K.W., Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Molecular Cell 2001, 7:673-682.
-
(2001)
Molecular Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
39
-
-
2942755868
-
Protein folding in the endoplasmic reticulum and the unfolded protein response
-
Zhang K., Kaufman R.J. Protein folding in the endoplasmic reticulum and the unfolded protein response. Journal of Biological Chemistry 2004, 279:25935-25938.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 25935-25938
-
-
Zhang, K.1
Kaufman, R.J.2
-
40
-
-
33644858343
-
The unfolded protein response: a stress signaling pathway critical for health and disease
-
Zhang K., Kaufman R.J. The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 2006, 66:S102-S109.
-
(2006)
Neurology
, vol.66
-
-
Zhang, K.1
Kaufman, R.J.2
|