Temporal alterations and cellular mechanisms of transmural repolarization during progression of mouse cardiac hypertrophy and failure

Acta Physiologica

Volumn 208, Issue 1, 2013, Pages 95-110

  Shi, C ^a   Wang, X ^a   Dong, F ^a   Wang, Y ^a   Hui, J ^a   Lin, Z ^a   Yang, J ^a   Xu, Y ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac hypertrophy; Heart failure; L type calcium channel; Mouse; Potassium channels; Transmural dispersion of repolarization

Indexed keywords

CALCIUM CHANNEL L TYPE; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ACTION POTENTIAL DURATION; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE OVERLOAD; J WAVE; MALE; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; RECEPTOR DOWN REGULATION; TRANSMURAL DISPERSION OF REPOLARIZATION;

ACTION POTENTIALS; ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS, L-TYPE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ECHOCARDIOGRAPHY, DOPPLER; ELECTROCARDIOGRAPHY; HEART FAILURE; HEART VENTRICLES; HEMODYNAMICS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84876313821     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12071     Document Type: Article

References (43)

1. Ahmmed, G.U., Dong, P.H., Song, G., Ball, N.A., Xu, Y., Walsh, R.A. & Chiamvimonvat, N. 2000 Changes in Ca(2 + ) cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Circ Res 86, 558-570.
2. Akar, F.G. & Rosenbaum, D.S. 2003 Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res 93, 638-645.
3. Akar, F.G., Spragg, D.D., Tunin, R.S., Kass, D.A. & Tomaselli, G.F. 2004 Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res 95, 717-725.
4. Amlie, J.P. 1999 Increased dispersion of repolarization in patients with arrhythmogenic right ventricular dysplasia-a major electrophysiological factor responsible for malignant ventricular arrhythmias. Eur Heart J 20, 703-705.
5. Antzelevitch, C. & Oliva, A. 2006 Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes. J Intern Med 259, 48-58.
6. Bers, D.M., Pogwizd, S.M. & Schlotthauer, K. 2002 Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Res Cardiol 97(Suppl. 1), I36-I42.
7. Bondarenko, V.E. & Rasmusson, R.L. 2010 Transmural heterogeneity of repolarization and Ca2 + handling in a model of mouse ventricular tissue. Am J Physiol Heart Circ Physiol 299, H454-H469.
8. Brunet, S., Aimond, F., Li, H., Guo, W., Eldstrom, J., Fedida, D., Yamada, K.A. & Nerbonne, J.M. 2004 Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol 559, 103-120.
9. Bryant, S.M., Shipsey, S.J. & Hart, G. 1999 Normal regional distribution of membrane current density in rat left ventricle is altered in catecholamine-induced hypertrophy. Cardiovasc Res 42, 391-401.
10. Cutler, M.J., Jeyaraj, D. & Rosenbaum, D.S. 2011 Cardiac electrical remodeling in health and disease. Trends Pharmacol Sci 32, 174-180.
11. Ding, B., Price, R.L., Goldsmith, E.C., Borg, T.K., Yan, X., Douglas, P.S., Weinberg, E.O., Bartunek, J., Thielen, T., Didenko, V.V. & Lorell, B.H. 2000 Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. Circulation 101, 2854-2862.
12. Dong, D., Duan, Y., Guo, J., Roach, D.E., Swirp, S.L., Wang, L., Lees-Miller, J.P., Sheldon, R.S., Molkentin, J.D. & Duff, H.J. 2003 Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels. Cardiovasc Res 57, 320-332.
13. Furukawa, T. & Kurokawa, J. 2006 Potassium channel remodeling in cardiac hypertrophy. J Mol Cell Cardiol 41, 753-761.
14. Glukhov, A.V., Fedorov, V.V., Lou, Q., Ravikumar, V.K., Kalish, P.W., Schuessler, R.B., Moazami, N. & Efimov, I.R. 2010 Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 106, 981-991.
15. Glukhov, A.V., Fedorov, V.V., Kalish, P.W., Ravikumar, V.K., Lou, Q., Janks, D., Schuessler, R.B., Moazami, N. & Efimov, I.R. 2012 Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation 125, 1835-1847.
16. Hobai, I.A. & O'Rourke, B. 2000 Enhanced Ca(2 + )-activated Na(+)-Ca(2 + ) exchange activity in canine pacing-induced heart failure. Circ Res 87, 690-698.
17. Jin, H., Chemaly, E.R., Lee, A., Kho, C., Hadri, L., Hajjar, R.J. & Akar, F.G. 2010 Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. Faseb J 24, 451-463.
18. Killeen, M.J., Thomas, G., Gurung, I.S., Goddard, C.A., Fraser, J.A., Mahaut-Smith, M.P., Colledge, W.H., Grace, A.A. & Huang, C.L. 2007 Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 189, 33-46.
19. Killeen, M.J., Thomas, G., Sabir, I.N., Grace, A.A. & Huang, C.L. 2008 Mouse models of human arrhythmia syndromes. Acta Physiol (Oxf) 192, 455-469.
20. Liu, G., Iden, J.B., Kovithavongs, K., Gulamhusein, R., Duff, H.J. & Kavanagh, K.M. 2004 In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. J Physiol 555, 267-279.
21. Lukas, A. & Antzelevitch, C. 1996 Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia. Cardiovasc Res 32, 593-603.
22. Marionneau, C., Brunet, S., Flagg, T.P., Pilgram, T.K., Demolombe, S. & Nerbonne, J.M. 2008 Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Circ Res 102, 1406-1415.
23. Mitchell, G.F., Jeron, A. & Koren, G. 1998 Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol 274, H747-H751.
24. Nerbonne, J.M. 2004 Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms? Trends Cardiovasc Med 14, 83-93.
25. Nerbonne, J.M. & Kass, R.S. 2005 Molecular physiology of cardiac repolarization. Physiol Rev 85, 1205-1253.
26. Niwa, N., Wang, W., Sha, Q., Marionneau, C. & Nerbonne, J.M. 2008 Kv4.3 is not required for the generation of functional Ito, f channels in adult mouse ventricles. J Mol Cell Cardiol 44, 95-104.
27. Poelzing, S. & Rosenbaum, D.S. 2004 Altered connexin43 expression produces arrhythmia substrate in heart failure. Am J Physiol Heart Circ Physiol 287, H1762-H1770.
28. Richard, S., Leclercq, F., Lemaire, S., Piot, C. & Nargeot, J. 1998 Ca2 + currents in compensated hypertrophy and heart failure. Cardiovasc Res 37, 300-311.
29. Rosati, B., Grau, F., Rodriguez, S., Li, H., Nerbonne, J.M. & McKinnon, D. 2003 Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 548, 815-822.
30. Shi, C.X., Wang, Y.H., Dong, F., Zhang, Y.J. & Xu, Y.F. 2007 Transmural L-type calcium current in a pressure-overloaded mouse model with heart failure. Sheng Li Xue Bao 59, 19-26.
31. Stengl, M., Ramakers, C., Donker, D.W., Nabar, A., Rybin, A.V., Spatjens, R.L., van der Nagel, T., Wodzig, W.K., Sipido, K.R., Antoons, G., Moorman, A.F., Vos, M.A. & Volders, P.G. 2006 Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation. Cardiovasc Res 72, 90-100.
32. Tanaka, N., Dalton, N., Mao, L., Rockman, H.A., Peterson, K.L., Gottshall, K.R., Hunter, J.J., Chien, K.R. & Ross, J. Jr. 1996 Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation 94, 1109-1117.
33. Tomaselli, G.F. & Marban, E. 1999 Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42, 270-283.
34. Tomaselli, G.F. & Zipes, D.P. 2004 What causes sudden death in heart failure? Circ Res 95, 754-763.
35. Valdivia, C.R., Chu, W.W., Pu, J., Foell, J.D., Haworth, R.A., Wolff, M.R., Kamp, T.J. & Makielski, J.C. 2005 Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38, 475-483.
36. Volk, T. & Ehmke, H. 2002 Conservation of L-type Ca2 + current characteristics in endo- and epicardial myocytes from rat left ventricle with pressure-induced hypertrophy. Pflugers Arch 443, 399-404.
37. Volk, T.N.T., Schultz, J.H., Faulhaber, J. & Ehmke, H. 2001 Regional alterations of repolarizing K+ currents among the lefe ventricular free wall of rats with ascending aortic stenosis. J Physiol 530, 443-455.
38. Wang, Z., Kutschke, W., Richardson, K.E., Karimi, M. & Hill, J.A. 2001. Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin. Circulation 104, 1657-1663.
39. Wang, Y., Cheng, J., Joyner, R.W., Wagner, M.B. & Hill, J.A. 2006 Remodeling of early-phase repolarization: a mechanism of abnormal impulse conduction in heart failure. Circulation 113, 1849-1856.
40. Wang, Y., Cheng, J., Chen, G., Rob, F., Naseem, R.H., Nguyen, L., Johnstone, J.L. & Hill, J.A. 2007. Remodeling of outward K+ currents in pressure-overload heart failure. J Cardiovasc Electrophysiol 18, 869-875.
41. Weber dos Santos, R., Nygren, A., Otaviano Campos, F., Koch, H. & Giles, W.R. 2009 Experimental and theo-retical ventricular electrograms and their relation to electrophysiological gradients in the adult rat heart. Am J Physiol Heart Circ Physiol 297, H1521-H1534.
42. Xu, H., Guo, W. & Nerbonne, J.M. 1999 Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. J Gen Physiol 113, 661-678.
43. Xu, Y., Zhang, Z., Timofeyev, V., Sharma, D., Xu, D., Tuteja, D., Dong, P.H., Ahmmed, G.U., Ji, Y., Shull, G.E., Periasamy, M. & Chiamvimonvat, N. 2005 The effects of intracellular Ca2 + on cardiac K+ channel expression and activity: novel insights from genetically altered mice. J Physiol 562, 745-758.