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Volumn 18, Issue 2, 2013, Pages 71-75

Antioxidant action of the hexahydropyridoindole SMe1EC2 in the cellular system of isolated red blood cells in vitro

Author keywords

Antioxidant; Free radical; Hemolysis; Hexahydropyridoindole; Oxidative stress; SMe1EC2; Stobadine

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; CIS 8 METHOXY 2,3,4,4A,5,9B HEXAHYDRO 1H PYRIDO [4,3B]INDOLE 2 CARBOXYLIC ACID ETHYL ESTER; FREE RADICAL; STOBADINE; TROLOX C; UNCLASSIFIED DRUG;

EID: 84876305234     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/1351000213Y.0000000043     Document Type: Article
Times cited : (14)

References (26)
  • 2
    • 0345676510 scopus 로고    scopus 로고
    • Antioxidant and pharmacodynamic effects of pyridoindole stobadine
    • Horakova L, Stolc S. Antioxidant and pharmacodynamic effects of pyridoindole stobadine. Gen Pharmacol 1998;30:627-38.
    • (1998) Gen Pharmacol , vol.30 , pp. 627-638
    • Horakova, L.1    Stolc, S.2
  • 3
    • 77950662469 scopus 로고    scopus 로고
    • Antioxidants in treating pathologies involving oxidative damage: An update on medicinal chemistry and biological activity of stobadine and related pyridoindoles
    • Juranek I, Horakova L, Rackova L, Stefek M. Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles. Curr Med Chem 2010;17:552-70.
    • (2010) Curr Med Chem , vol.17 , pp. 552-570
    • Juranek, I.1    Horakova, L.2    Rackova, L.3    Stefek, M.4
  • 4
    • 84894171801 scopus 로고    scopus 로고
    • Stobadine - An indole type alternative to the phenolic antioxidant reference trolox
    • In: Ekinci D, (ed.)
    • Juranek I, Rackova L, Stefek M. Stobadine - an indole type alternative to the phenolic antioxidant reference trolox. In: Ekinci D, (ed.) Biochemistry. Rijeka: InTech; 2012. p. 443-52.
    • (2012) Biochemistry. Rijeka: InTech , pp. 443-452
    • Juranek, I.1    Rackova, L.2    Stefek, M.3
  • 5
    • 33646095778 scopus 로고    scopus 로고
    • Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure-activity relationships
    • Rackova L, Snirc V, Majekova M, Majek P, Stefek M. Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure-activity relationships. J Med Chem 2006;49:2543-8.
    • (2006) J Med Chem , vol.49 , pp. 2543-2548
    • Rackova, L.1    Snirc, V.2    Majekova, M.3    Majek, P.4    Stefek, M.5
  • 6
    • 84888871889 scopus 로고    scopus 로고
    • Pyridoindole derivatives with antioxidant properties: Synthesis, therapy and pharmaceutical remedies
    • Stolc S, Povazanec F, Bauer V, Majekova M, Wilcox AL, Snirc V, et al. Pyridoindole derivatives with antioxidant properties: synthesis, therapy and pharmaceutical remedies. Slovak Patent Agency; 2010: P 287506.
    • (2010) Slovak Patent Agency , pp. 2875-2906
    • Stolc, S.1    Povazanec, F.2    Bauer, V.3    Majekova, M.4    Wilcox, A.L.5    Snirc, V.6
  • 7
    • 0036378834 scopus 로고    scopus 로고
    • Structural aspects of antioxidant activity of substituted pyridoindoles
    • Rackova L, Stefek M, Majekova M. Structural aspects of antioxidant activity of substituted pyridoindoles. Redox Rep 2002;7(4): 207-14.
    • (2002) Redox Rep , vol.7 , Issue.4 , pp. 207-214
    • Rackova, L.1    Stefek, M.2    Majekova, M.3
  • 8
    • 33845539511 scopus 로고    scopus 로고
    • Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress
    • Stolc S, Snirc V, Majekova M, Gasparova Z, Gajdosikova A, Stvrtina S. Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. Cell Mol Neurobiol 2006;26(7-8):1495-504.
    • (2006) Cell Mol Neurobiol , vol.26 , Issue.7-8 , pp. 1495-1504
    • Stolc, S.1    Snirc, V.2    Majekova, M.3    Gasparova, Z.4    Gajdosikova, A.5    Stvrtina, S.6
  • 9
    • 77649268279 scopus 로고    scopus 로고
    • Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro
    • Gasparova Z, Janega P, Babal P, Snirc V, Stolc S, Mach M, et al. Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuro Endocrinol Lett 2009;30: 574-81.
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 574-581
    • Gasparova, Z.1    Janega, P.2    Babal, P.3    Snirc, V.4    Stolc, S.5    Mach, M.6
  • 10
    • 79551601421 scopus 로고    scopus 로고
    • Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: Effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue
    • Gasparova Z, Ondrejickova O, Gajdosikova A, Gajdosik A, Snirc V, Stolc S. Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue. Interdiscip Toxicol 2010;3:122-6.
    • (2010) Interdiscip Toxicol , vol.3 , pp. 122-126
    • Gasparova, Z.1    Ondrejickova, O.2    Gajdosikova, A.3    Gajdosik, A.4    Snirc, V.5    Stolc, S.6
  • 11
    • 79955095590 scopus 로고    scopus 로고
    • The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemiainduced impairment of longterm potentiation in rat hippocampus
    • Gasparova Z, Snirc V, Stolc S. The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemiainduced impairment of longterm potentiation in rat hippocampus. Interdiscip Toxicol 2010;4:56-61.
    • (2010) Interdiscip Toxicol , vol.4 , pp. 56-61
    • Gasparova, Z.1    Snirc, V.2    Stolc, S.3
  • 13
    • 70349333841 scopus 로고    scopus 로고
    • Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells
    • Rackova L, Snirc V, Jung T, Stefek M, Karasu C, Grune T. Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells. Free Radic Res 2009;43: 876-86.
    • (2009) Free Radic Res , vol.43 , pp. 876-886
    • Rackova, L.1    Snirc, V.2    Jung, T.3    Stefek, M.4    Karasu, C.5    Grune, T.6
  • 14
    • 80755176742 scopus 로고    scopus 로고
    • Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells
    • Rackova L, Cumaoglu A, Bagriacik EU, Stefek M, Maechler P, Karasu C. Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells. Med Chem 2011;7:711-7.
    • (2011) Med Chem , vol.7 , pp. 711-717
    • Rackova, L.1    Cumaoglu, A.2    Bagriacik, E.U.3    Stefek, M.4    Maechler, P.5    Karasu, C.6
  • 16
    • 0025145949 scopus 로고
    • Oxidative reactions of hemoglobin
    • Winterbourn CC. Oxidative reactions of hemoglobin. Meth Enzymol 1990;186:265-72.
    • (1990) Meth Enzymol , vol.186 , pp. 265-272
    • Winterbourn, C.C.1
  • 17
    • 0025983604 scopus 로고
    • Pyridoindole stobadine is a potent scavenger of hydroxyl radicals
    • Stefek M, Benes L. Pyridoindole stobadine is a potent scavenger of hydroxyl radicals. FEBS Lett 1991;294:264-6.
    • (1991) FEBS Lett , vol.294 , pp. 264-266
    • Stefek, M.1    Benes, L.2
  • 18
    • 0026784064 scopus 로고
    • Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen
    • Steenken S, Sunquist AR, Jovanovic SV, Crockett R, Sies H. Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen. Chem Res Toxicol 1992;5:355-60.
    • (1992) Chem Res Toxicol , vol.5 , pp. 355-360
    • Steenken, S.1    Sunquist, A.R.2    Jovanovic, S.V.3    Crockett, R.4    Sies, H.5
  • 19
    • 0026623264 scopus 로고
    • Inhibition of cumene hydroperoxide-induced lipid peroxidation by a novel pyridoindole antioxidant in rat liver microsomes
    • Stefek M, Masarykova M, Benes L. Inhibition of cumene hydroperoxide-induced lipid peroxidation by a novel pyridoindole antioxidant in rat liver microsomes. Pharmacol Toxicol 1992; 70:407-11.
    • (1992) Pharmacol Toxicol , vol.70 , pp. 407-411
    • Stefek, M.1    Masarykova, M.2    Benes, L.3
  • 20
    • 0027398196 scopus 로고
    • Interaction of the pyridoindole stobadine with peroxyl, superoxide and chromanoxyl radicals
    • Kagan VE, Tsuchiya M, Serbinova E, Packer L, Sies H. Interaction of the pyridoindole stobadine with peroxyl, superoxide and chromanoxyl radicals. Biochem Pharmacol 1993;45: 393-400.
    • (1993) Biochem Pharmacol , vol.45 , pp. 393-400
    • Kagan, V.E.1    Tsuchiya, M.2    Serbinova, E.3    Packer, L.4    Sies, H.5
  • 21
    • 0030071934 scopus 로고    scopus 로고
    • The pyridoindole antioxidant stobadine prevents alloxan-induced lipid peroxidation by inhibiting its propagation
    • Stefek M, Trnkova Z. The pyridoindole antioxidant stobadine prevents alloxan-induced lipid peroxidation by inhibiting its propagation. Pharmacol Toxicol 1996;78:77-81.
    • (1996) Pharmacol Toxicol , vol.78 , pp. 77-81
    • Stefek, M.1    Trnkova, Z.2
  • 22
    • 36949063535 scopus 로고
    • Antioxidant determinations by the use of a stable free radical
    • Blois MS. Antioxidant determinations by the use of a stable free radical. Nature 1958;181:1199-200.
    • (1958) Nature , vol.181 , pp. 1199-1200
    • Blois, M.S.1
  • 23
    • 0025082043 scopus 로고
    • Free radicals initiators as source of water- or lipidsoluble peroxyl radicals
    • Niki E. Free radicals initiators as source of water- or lipidsoluble peroxyl radicals. Methods Enzymol 1990;186:100-8.
    • (1990) Methods Enzymol , vol.186 , pp. 100-108
    • Niki, E.1
  • 24
    • 0020955573 scopus 로고
    • Lipid peroxidation and haemoglobin degradation in red blood cells exposed to t-butyl hydroperoxide. The relative roles of haem- and glutathionedependent decomposition of t-butyl hydroperoxide and membrane lipid hydroperoxides in lipid peroxidation and haemolysis
    • Trotta RJ, Sullivan SG, Stern A. Lipid peroxidation and haemoglobin degradation in red blood cells exposed to t-butyl hydroperoxide. The relative roles of haem- and glutathionedependent decomposition of t-butyl hydroperoxide and membrane lipid hydroperoxides in lipid peroxidation and haemolysis. Biochem J 1983;212(3):759-72.
    • (1983) Biochem J , vol.212 , Issue.3 , pp. 759-772
    • Trotta, R.J.1    Sullivan, S.G.2    Stern, A.3
  • 25
    • 0020965547 scopus 로고
    • Free radical involvement in the oxidative phenomena induced by tert-butyl hydroperoxide in erythrocytes
    • Thornalley PJ, Trotta RJ, Stern A. Free radical involvement in the oxidative phenomena induced by tert-butyl hydroperoxide in erythrocytes. Biochim Biophys Acta 1983;759(1-2): 16-22.
    • (1983) Biochim Biophys Acta , vol.759 , Issue.1-2 , pp. 16-22
    • Thornalley, P.J.1    Trotta, R.J.2    Stern, A.3
  • 26
    • 0024546562 scopus 로고
    • N-oxygenation of stobadine, a gamma-carboline antiarrhytmic and cardioprotective agent: The role of flavin-containing monooxygenase
    • Stefek M, Benes L, Zelnik V. N-oxygenation of stobadine, a gamma-carboline antiarrhytmic and cardioprotective agent: the role of flavin-containing monooxygenase. Xenobiotica 1989;19: 143-50.
    • (1989) Xenobiotica , vol.19 , pp. 143-150
    • Stefek, M.1    Benes, L.2    Zelnik, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.