The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemia-induced impairment of long-term potentiation in rat hippocampus

Interdisciplinary Toxicology

Volumn 4, Issue 1, 2011, Pages 56-61

  Gáspárová, Zdenka ^a   Šnirc, Vladimír ^a   Štolc, Svorad ^a,b  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Biont as   (Slovakia)

Author keywords

hippocampus; long term potentiation; oxidative stress; pyridoindole; rat

Indexed keywords

ANTIOXIDANT; CARBOLINE DERIVATIVE; SME1EC2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOXIA; IN VITRO STUDY; INTERVENTION STUDY; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; RAT;

HELIOTHIS ZEA VIRUS 1; RATTUS;

EID: 79955095590     PISSN: 13376853     EISSN: 13379569     Source Type: Journal    
DOI: 10.2478/v10102-011-0011-0     Document Type: Article

References (33)

1. Cao XJ, Wang M, Chen WH, Zhu DM, She JQ, Ruan DY. (2009). Effects of chronic administration of melatonin on spatial learning ability and longterm potentiation in lead-exposed and control rats. Biomed Environ Sci 22: 70-75.
2. Cooke SF, Bliss TVP. (2006). Plasticity in the human central nervous system. Brain 129: 1659-1673. (Pubitemid 43999401)
3. Dai X, Chen L, Sokabe M. (2007). Neurosteroid estradiol rescues ischemia-induced defi cit in the long-term potentiation of rat hippocampal CA1 neurons. Neuropharmacology 52: 1124-1138.
4. Ito C, Im WB, Takagi H, Takahashi M, Tsuzuki K, Liou SY, Kunihara M. (1994). U-92032, a T-type Ca2+ channel blocker and antioxidant, reduces neuronal ischemic injuries. Eur J Pharmacol 257: 203-210. (Pubitemid 24154575)
5. Fisher M. (2011). New approaches to neuroprotective drug development. Stroke 42[suppl 1]: S24-S27.
6. Horáková L, Štolc S. (1998). Antioxidant and pharmacodynamic effect of pyridoindole stobadine. Gen Pharmacol 30: 627-638. (Pubitemid 28167763)
7. Gáspárová Z, Jariabka P, Štolc S. (2008). Effect of transient ischemia on longterm potentiation of synaptic transmission in rat hippocampal slices. Neuro Endocrinol Lett 29: 702-705.
8. Gáspárová Z, Janega P, Babál P, Šnirc V, Štolc S, Mach M, Ujházy E. (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional defi cits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuro Endocrinol Lett 30: 574-581.
9. Gáspárová Z, Ondrejièková O, Gajdošíková A, Gajdošík A, Šnirc V, Štolc S. (2010a). Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: Effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue. Interdiscip Toxicol 3: 122-126.
10. Gáspárová Z, Šnirc V, Štolc S, Dubovický M, Mach M, Ujházy E. (2010b). Maternal treatment of rats with the new pyridoindole antioxidant during pregnancy and lactation resulting in improved off spring hippocampal resistance to ischemia in vitro. NeuroEndocrinol Lett 31: 348-352.
11. Gáspárová-Kvaltínová Z, Štolc S. (2003). Effect of antioxidants and NMDA antagonists on the density of NMDA binding sites in rat hippocampal slices exposed to hypoxia/reoxygenation. Methods Find Exp Clin Pharmacol 25: 17-25. (Pubitemid 36313922)
12. Gemma C, Vila J, Bachstetter A, Bickford PC. (2007). Oxidative stress and the aging brain: from theory to prevention. In: Brain aging: Models, Methods, and Mechanisms. Ed Riddle DR, Boca Raton (FL), CRC Press, Chapter 15.
13. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral defi cits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19: 8114-8121. (Pubitemid 30225807)
14. Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A, Taglialatela G, Bickford PC. (1998). Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral defi cits. J Neurosci 18: 8047-8055. (Pubitemid 28441042)
15. Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfi eld DA, Markesbery WR. (2005). Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology 64:1152-1156.
16. Kvaltínová Z, Štolc S. (1997). NMDA binding sites in rat hippocampus under oxidative stress: Effect of antioxidants and NMDA antagonists. Ann N Y Acad Sci 812: 240-242.
17. Maalouf M, Rho JM. (2008). Oxidative impairment of hippocampal long-term potentiation involves activation of protein Phosphatase 2A and is prevented by ketone bodies. J Neurosci Res 86: 3322-3330.
18. Mariani E, Polidori MC, Cherubini A, Mecocci P. (2005). Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 827: 65-75. (Pubitemid 41551598)
19. Miyazaki S, Katayama Y, Lyeth BG, Jenkins LW, DeWitt DS, Goldberg SJ, Newlon PG, Hayes RL. (1992). Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat. Brain Res 585:335-339.
20. Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. (2006). Brain and brawn: parallels in oxidative strength. Neurology 66: S97-101. (Pubitemid 43739993)
21. Murray CA, Lynch MA. (1998). Dietary supplementation with vitamin E reverses the age-related defi cits in long-term potentiation in dentate gyrus. J Biol Chem 273: 12161.
22. Reeves TM, Lyeth BG, Povlishock JT. (1995). Long-term potentiation defi cits and excitability changes following traumatic brain injury. Exp Brain Res 106: 248-256.
23. Sanders MJ, Sick TJ, Perez-Pinzon MA, Dietrich WD, Green EJ. (2000). Chronic failure in the maintenance of long-term potentiation following fl uid percussion injury in the rat. Brain Res 861: 69-76. (Pubitemid 30177284)
24. Schwarzbach E, Bonislawski DP, Xiong G, Cohen AS. (2006). Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury. Hippocampus 16: 541-550. (Pubitemid 43942102)
25. Sick TJ, Perez-Pinzon MA, Feng ZZ. (1998). Impaired expression of long-term potentiation in hippocampal slices 4 and 48 h following mild fl uid-percussion brain injury in vivo. Brain Res 785: 287-292. (Pubitemid 28179391)
26. Sopala M, Frankiewicz T, Parsons C, Danysz W. (2000). Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats involvement of N-methyl-D-aspartate receptors? Neurosci Lett 281:143-146. (Pubitemid 30125885)
27. Štolc S, Šnirc V, Májeková M, Gáspárová Z, Gajdošíková A, Štvrtina S (2006). Development of the new group of indole-derived neuroprotective drugs aff ecting oxidative stress. Cell Mol Neurobiol. 26, 1493-1502.
28. Štolc S, Šnirc V, Gajdošíková A, Gajdošík A, Gáspárová Z, Ondrejiè ková O, Sotníková R, Viola A, Rapta P, Jariabka P, Syneková I, Vajdová M, Zacharová S, Nemèek V, Krchnárová V. (2008). New pyridoindoles with antioxidant and neuroprotective actions. In: Trends in pharmacological research (V. Bauer, ed.) pp. 118-136, Institute of Experimental Pharmacology, Bratislava, Slovakia.
29. Štolc S, Považanec F, Bauer V, Májeková M, Wilcox AL, Šnirc V, Raèková L, Sotníková R, Štefek M, Gáspárová Z, Gajdoší ková A, Mihálová D, Alfoldi J. (2010). Pyridoindole derivatives with antioxidant properties: their synthesis and use in therapeutic practice (in Slovak) Slovak, Patent No. 287506.
30. Tariq A., Ai J, Chen G, Sabri M, Jeon H., Shang X, Macdonald RL. (2010). Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats. Neuroscience 165: 418-426.
31. Velísek L. (1998). Extracellular acidosis and high level of carbon dioxide suppress synaptic transmission and prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices. Hippocampus 8: 24-32. (Pubitemid 28108146)
32. Yang J, Jiang LN, Yuan ZL, Zheng YF, Wang L, Ji M, Shen ZQ, Wang XW, Ma Q, Xi ZG, Li JW. (2008). Impacts of passive smoking on learning and memory ability of mouse off spring and intervention by antioxidants. Biomed Environ Sci 21: 144-149. (Pubitemid 351702406)
33. Wang HL, Chen XT, Yin ST, Liu J, Tang ML, Wu CY, Ruan DY. (2008). Opposite effects of alpha-lipoic acid on antioxidation and long-term potentiation in control and chronically lead-exposed rats. Naunyn Schmied Arch Pharmacol 378: 303-310.