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Volumn 54, Issue , 2013, Pages 239-251

Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype

Author keywords

Alcoholism; Alternative activation; Blood brain barrier; Cytokine; Entorhinal cortex; Ethanol; Hippocampus; Inflammation; Microgliosis

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84876304760     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.12.016     Document Type: Article
Times cited : (197)

References (119)
  • 1
    • 84860215152 scopus 로고    scopus 로고
    • The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion
    • Abdul Muneer P.M., Alikunju S., Szlachetka A.M., Haorah J. The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion. Arterioscler. Thromb. Vasc. Biol. 2012, 32:1167-1177.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1167-1177
    • Abdul Muneer, P.M.1    Alikunju, S.2    Szlachetka, A.M.3    Haorah, J.4
  • 3
    • 0025162755 scopus 로고
    • Brain microglia constitutively express beta-2 integrins
    • Akiyama H., McGeer P.L. Brain microglia constitutively express beta-2 integrins. J. Neuroimmunol. 1990, 30:81-93.
    • (1990) J. Neuroimmunol. , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 6
    • 33644960523 scopus 로고    scopus 로고
    • Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    • Battista D., Ferrari C.C., Gage F.H., Pitossi F.J. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur. J. Neurosci. 2006, 23:83-93.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 83-93
    • Battista, D.1    Ferrari, C.C.2    Gage, F.H.3    Pitossi, F.J.4
  • 7
    • 0028339366 scopus 로고
    • Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis
    • Bauer J., Sminia T., Wouterlood F.G., Dijkstra C.D. Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J. Neurosci. Res. 1994, 38:365-375.
    • (1994) J. Neurosci. Res. , vol.38 , pp. 365-375
    • Bauer, J.1    Sminia, T.2    Wouterlood, F.G.3    Dijkstra, C.D.4
  • 9
    • 43649099789 scopus 로고    scopus 로고
    • Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury
    • (Chapter 7:Unit7)
    • Benavides J., Dubois A., Scatton B. Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury. Curr. Protoc. Neurosci. 2001, 16. (Chapter 7:Unit7).
    • (2001) Curr. Protoc. Neurosci. , pp. 16
    • Benavides, J.1    Dubois, A.2    Scatton, B.3
  • 10
    • 0032739262 scopus 로고    scopus 로고
    • Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats
    • Bethea J.R., Nagashima H., Acosta M.C., Briceno C., Gomez F., Marcillo A.E., Loor K., Green J., Dietrich W.D. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma 1999, 16:851-863.
    • (1999) J. Neurotrauma , vol.16 , pp. 851-863
    • Bethea, J.R.1    Nagashima, H.2    Acosta, M.C.3    Briceno, C.4    Gomez, F.5    Marcillo, A.E.6    Loor, K.7    Green, J.8    Dietrich, W.D.9
  • 11
    • 77649139342 scopus 로고    scopus 로고
    • Early-life programming of later-life brain and behavior: a critical role for the immune system
    • Bilbo S.D., Schwarz J.M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front. Behav. Neurosci. 2009, 3:14.
    • (2009) Front. Behav. Neurosci. , vol.3 , pp. 14
    • Bilbo, S.D.1    Schwarz, J.M.2
  • 12
    • 77950947668 scopus 로고    scopus 로고
    • Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain
    • Bland S.T., Beckley J.T., Young S., Tsang V., Watkins L.R., Maier S.F., Bilbo S.D. Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain Behav. Immun. 2010, 24:329-338.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 329-338
    • Bland, S.T.1    Beckley, J.T.2    Young, S.3    Tsang, V.4    Watkins, L.R.5    Maier, S.F.6    Bilbo, S.D.7
  • 13
    • 79955713366 scopus 로고    scopus 로고
    • Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice
    • Blednov Y.A., Benavidez J.M., Geil C., Perra S., Morikawa H., Harris R.A. Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav. Immun. 2011, 25:S92-S105.
    • (2011) Brain Behav. Immun. , vol.25
    • Blednov, Y.A.1    Benavidez, J.M.2    Geil, C.3    Perra, S.4    Morikawa, H.5    Harris, R.A.6
  • 14
    • 84255187288 scopus 로고    scopus 로고
    • Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies
    • Blednov Y.A., Ponomarev I., Geil C., Bergeson S., Koob G.F., Harris R.A. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict. Biol. 2012, 17:108-120.
    • (2012) Addict. Biol. , vol.17 , pp. 108-120
    • Blednov, Y.A.1    Ponomarev, I.2    Geil, C.3    Bergeson, S.4    Koob, G.F.5    Harris, R.A.6
  • 15
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 2005, 76:77-98.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 16
    • 34848863163 scopus 로고    scopus 로고
    • A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease
    • Carson M.J., Bilousova T.V., Puntambekar S.S., Melchior B., Doose J.M., Ethell I.M. A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease. Neurotherapeutics 2007, 4:571-579.
    • (2007) Neurotherapeutics , vol.4 , pp. 571-579
    • Carson, M.J.1    Bilousova, T.V.2    Puntambekar, S.S.3    Melchior, B.4    Doose, J.M.5    Ethell, I.M.6
  • 17
    • 0028598750 scopus 로고
    • Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice
    • Chiang C.S., Stalder A., Samimi A., Campbell I.L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev. Neurosci. 1994, 16:212-221.
    • (1994) Dev. Neurosci. , vol.16 , pp. 212-221
    • Chiang, C.S.1    Stalder, A.2    Samimi, A.3    Campbell, I.L.4
  • 18
    • 0029870044 scopus 로고    scopus 로고
    • Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics
    • Collins M.A., Corse T.D., Neafsey E.J. Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol. Clin. Exp. Res. 1996, 20:284-292.
    • (1996) Alcohol. Clin. Exp. Res. , vol.20 , pp. 284-292
    • Collins, M.A.1    Corse, T.D.2    Neafsey, E.J.3
  • 19
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • Colton C.A., Gilbert D.L. Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett. 1987, 223:284-288.
    • (1987) FEBS Lett. , vol.223 , pp. 284-288
    • Colton, C.A.1    Gilbert, D.L.2
  • 21
    • 0033491266 scopus 로고    scopus 로고
    • Alcohol and neurodegeneration
    • Crews F.T. Alcohol and neurodegeneration. CNS Drug Rev. 1999, 5:379-394.
    • (1999) CNS Drug Rev. , vol.5 , pp. 379-394
    • Crews, F.T.1
  • 22
    • 67649439164 scopus 로고    scopus 로고
    • Impulsivity, frontal lobes and risk for addiction
    • Crews F.T., Boettiger C.A. Impulsivity, frontal lobes and risk for addiction. Pharmacol. Biochem. Behav. 2009, 93:237-247.
    • (2009) Pharmacol. Biochem. Behav. , vol.93 , pp. 237-247
    • Crews, F.T.1    Boettiger, C.A.2
  • 23
    • 61449176928 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration and regeneration in alcoholism
    • Crews F.T., Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol 2009, 44:115-127.
    • (2009) Alcohol , vol.44 , pp. 115-127
    • Crews, F.T.1    Nixon, K.2
  • 24
    • 0033739075 scopus 로고    scopus 로고
    • Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats
    • Crews F.T., Braun C.J., Hoplight B., Switzer R.C., Knapp D.J. Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol. Clin. Exp. Res. 2000, 24:1712-1723.
    • (2000) Alcohol. Clin. Exp. Res. , vol.24 , pp. 1712-1723
    • Crews, F.T.1    Braun, C.J.2    Hoplight, B.3    Switzer, R.C.4    Knapp, D.J.5
  • 26
    • 79955729616 scopus 로고    scopus 로고
    • Induction of innate immune genes in brain create the neurobiology of addiction
    • Crews F.T., Zou J., Qin L. Induction of innate immune genes in brain create the neurobiology of addiction. Brain Behav. Immun. 2011, 25:S4-S12.
    • (2011) Brain Behav. Immun. , vol.25
    • Crews, F.T.1    Zou, J.2    Qin, L.3
  • 29
    • 0032983595 scopus 로고    scopus 로고
    • Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    • Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim. Biophys. Acta 1999, 1450:191-231.
    • (1999) Biochim. Biophys. Acta , vol.1450 , pp. 191-231
    • Donato, R.1
  • 30
    • 0142229704 scopus 로고    scopus 로고
    • Intracellular and extracellular roles of S100 proteins
    • Donato R. Intracellular and extracellular roles of S100 proteins. Microsc. Res. Tech. 2003, 60:540-551.
    • (2003) Microsc. Res. Tech. , vol.60 , pp. 540-551
    • Donato, R.1
  • 31
    • 84858009243 scopus 로고    scopus 로고
    • Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats
    • Ehrlich D., Pirchl M., Humpel C. Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. Neuroscience 2012, 205:154-166.
    • (2012) Neuroscience , vol.205 , pp. 154-166
    • Ehrlich, D.1    Pirchl, M.2    Humpel, C.3
  • 33
    • 70449732755 scopus 로고    scopus 로고
    • Critical role of TLR4 response in the activation of microglia induced by ethanol
    • Fernandez-Lizarbe S., Pascual M., Guerri C. Critical role of TLR4 response in the activation of microglia induced by ethanol. J. Immunol. 2009, 183:4733-4744.
    • (2009) J. Immunol. , vol.183 , pp. 4733-4744
    • Fernandez-Lizarbe, S.1    Pascual, M.2    Guerri, C.3
  • 35
    • 0024518511 scopus 로고
    • Selective localization by neuroglia of immunoglobulin G in normal mice
    • Fishman P.S., Savitt J.M. Selective localization by neuroglia of immunoglobulin G in normal mice. J. Neuropathol. Exp. Neurol. 1989, 48:212-220.
    • (1989) J. Neuropathol. Exp. Neurol. , vol.48 , pp. 212-220
    • Fishman, P.S.1    Savitt, J.M.2
  • 36
    • 77649184973 scopus 로고    scopus 로고
    • Microglia: biology and pathology
    • Graeber M.B., Streit W.J. Microglia: biology and pathology. Acta Neuropathol. 2009, 119:89-105.
    • (2009) Acta Neuropathol. , vol.119 , pp. 89-105
    • Graeber, M.B.1    Streit, W.J.2
  • 37
    • 0024255828 scopus 로고
    • Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
    • Graeber M.B., Streit W.J., Kreutzberg G.W. Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J. Neurosci. Res. 1988, 21:18-24.
    • (1988) J. Neurosci. Res. , vol.21 , pp. 18-24
    • Graeber, M.B.1    Streit, W.J.2    Kreutzberg, G.W.3
  • 38
    • 81755173570 scopus 로고    scopus 로고
    • Role of microglia in CNS inflammation
    • Graeber M.B., Li W., Rodriguez M.L. Role of microglia in CNS inflammation. FEBS Lett. 2011, 585:3798-3805.
    • (2011) FEBS Lett. , vol.585 , pp. 3798-3805
    • Graeber, M.B.1    Li, W.2    Rodriguez, M.L.3
  • 39
    • 0033045425 scopus 로고    scopus 로고
    • The efficiency of systematic sampling in stereology-reconsidered
    • Gundersen H.J., Jensen E.B., Kieu K., Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J. Microsc. 1999, 193:199-211.
    • (1999) J. Microsc. , vol.193 , pp. 199-211
    • Gundersen, H.J.1    Jensen, E.B.2    Kieu, K.3    Nielsen, J.4
  • 40
    • 53949089392 scopus 로고    scopus 로고
    • Acute, regional inflammatory response after traumatic brain injury: implications for cellular therapy
    • Harting M.T., Jimenez F., Adams S.D., Mercer D.W., Cox C.S. Acute, regional inflammatory response after traumatic brain injury: implications for cellular therapy. Surgery 2008, 144:803-813.
    • (2008) Surgery , vol.144 , pp. 803-813
    • Harting, M.T.1    Jimenez, F.2    Adams, S.D.3    Mercer, D.W.4    Cox, C.S.5
  • 41
    • 41349093774 scopus 로고    scopus 로고
    • Increased MCP-1 and microglia in various regions of the human alcoholic brain
    • He J., Crews F.T. Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp. Neurol. 2008, 210:349-358.
    • (2008) Exp. Neurol. , vol.210 , pp. 349-358
    • He, J.1    Crews, F.T.2
  • 42
    • 0025978546 scopus 로고
    • Intracellular calcium-binding proteins: more sites than insights
    • Heizmann C.W., Hunziker W. Intracellular calcium-binding proteins: more sites than insights. Trends Biochem. Sci. 1991, 16:98-103.
    • (1991) Trends Biochem. Sci. , vol.16 , pp. 98-103
    • Heizmann, C.W.1    Hunziker, W.2
  • 43
    • 0035155254 scopus 로고    scopus 로고
    • Basic principles of immunological surveillance of the normal central nervous system
    • Hickey W.F. Basic principles of immunological surveillance of the normal central nervous system. Glia 2001, 36:118-124.
    • (2001) Glia , vol.36 , pp. 118-124
    • Hickey, W.F.1
  • 44
    • 0027763251 scopus 로고
    • Are binge drinkers more at risk of developing brain damage?
    • Hunt W.A. Are binge drinkers more at risk of developing brain damage?. Alcohol 1993, 10:559-561.
    • (1993) Alcohol , vol.10 , pp. 559-561
    • Hunt, W.A.1
  • 45
    • 33746493978 scopus 로고    scopus 로고
    • Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion
    • Hwang I.K., Yoo K.Y., Kim D.W., Choi S.Y., Kang T.C., Kim Y.S., Won M.H. Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion. Neurochem. Res. 2006, 31:957-965.
    • (2006) Neurochem. Res. , vol.31 , pp. 957-965
    • Hwang, I.K.1    Yoo, K.Y.2    Kim, D.W.3    Choi, S.Y.4    Kang, T.C.5    Kim, Y.S.6    Won, M.H.7
  • 46
    • 0026770377 scopus 로고
    • Integrins: versatility, modulation, and signaling in cell adhesion
    • Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992, 69:11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 47
    • 0030601207 scopus 로고    scopus 로고
    • A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    • Imai Y., Ibata I., Ito D., Ohsawa K., Kohsaka S. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem. Biophys. Res. Commun. 1996, 224:855-862.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 855-862
    • Imai, Y.1    Ibata, I.2    Ito, D.3    Ohsawa, K.4    Kohsaka, S.5
  • 49
    • 0010610150 scopus 로고
    • Chronic ethanol treatment promotes aberrant microglial morphology in area CA1 of the rat hippocampus
    • Kalehua A.N., Streit W.J., Walker D.W., Hunter B.E. Chronic ethanol treatment promotes aberrant microglial morphology in area CA1 of the rat hippocampus. Alcohol. Clin. Exp. Res. 1992, 16:401.
    • (1992) Alcohol. Clin. Exp. Res. , vol.16 , pp. 401
    • Kalehua, A.N.1    Streit, W.J.2    Walker, D.W.3    Hunter, B.E.4
  • 50
    • 0029094436 scopus 로고
    • Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance
    • Kato H., Kogure K., Araki T., Itoyama Y. Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance. Brain Res. 1995, 694:85-93.
    • (1995) Brain Res. , vol.694 , pp. 85-93
    • Kato, H.1    Kogure, K.2    Araki, T.3    Itoyama, Y.4
  • 51
    • 0026766883 scopus 로고
    • Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain
    • Kaur C., Ling E.A. Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain. J. Anat. 1992, 180:333-342.
    • (1992) J. Anat. , vol.180 , pp. 333-342
    • Kaur, C.1    Ling, E.A.2
  • 52
    • 33645972942 scopus 로고    scopus 로고
    • The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice
    • Kelso M.L., Wehner J.M., Collins A.C., Scheff S.W., Pauly J.R. The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice. Brain Res. 2006, 1083:204-210.
    • (2006) Brain Res. , vol.1083 , pp. 204-210
    • Kelso, M.L.1    Wehner, J.M.2    Collins, A.C.3    Scheff, S.W.4    Pauly, J.R.5
  • 53
    • 70349757546 scopus 로고    scopus 로고
    • Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice
    • Kelso M.L., Scheff S.W., Pauly J.R., Loftin C.D. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. BMC Neurosci. 2009, 10:108.
    • (2009) BMC Neurosci. , vol.10 , pp. 108
    • Kelso, M.L.1    Scheff, S.W.2    Pauly, J.R.3    Loftin, C.D.4
  • 54
    • 82855165038 scopus 로고    scopus 로고
    • Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder
    • Kelso M.L., Liput D.J., Eaves D.W., Nixon K. Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder. Neuroscience 2011, 197:381-393.
    • (2011) Neuroscience , vol.197 , pp. 381-393
    • Kelso, M.L.1    Liput, D.J.2    Eaves, D.W.3    Nixon, K.4
  • 55
    • 0032906175 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal
    • Knapp D.J., Crews F.T. Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal. Alcohol. Clin. Exp. Res. 1999, 23:633-643.
    • (1999) Alcohol. Clin. Exp. Res. , vol.23 , pp. 633-643
    • Knapp, D.J.1    Crews, F.T.2
  • 56
    • 0030756351 scopus 로고    scopus 로고
    • Drug abuse: hedonic homeostatic dysregulation
    • Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science 1997, 278:52-58.
    • (1997) Science , vol.278 , pp. 52-58
    • Koob, G.F.1    Le Moal, M.2
  • 57
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 58
    • 38349086976 scopus 로고    scopus 로고
    • Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury
    • Lai A.Y., Todd K.G. Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury. Glia 2008, 56:259-270.
    • (2008) Glia , vol.56 , pp. 259-270
    • Lai, A.Y.1    Todd, K.G.2
  • 59
    • 0035083678 scopus 로고    scopus 로고
    • Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury
    • Lau L.T., Yu A.C. Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J. Neurotrauma 2001, 18:351-359.
    • (2001) J. Neurotrauma , vol.18 , pp. 351-359
    • Lau, L.T.1    Yu, A.C.2
  • 60
    • 0034032594 scopus 로고    scopus 로고
    • Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells
    • Ledeboer A., Breve J.J., Poole S., Tilders F.J., Van Dam A.M. Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia 2000, 30:134-142.
    • (2000) Glia , vol.30 , pp. 134-142
    • Ledeboer, A.1    Breve, J.J.2    Poole, S.3    Tilders, F.J.4    Van Dam, A.M.5
  • 62
    • 0016752279 scopus 로고
    • Induction of physical dependence upon ethanol and the associated behavioral changes in rats
    • Majchrowicz E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 1975, 43:245-254.
    • (1975) Psychopharmacologia , vol.43 , pp. 245-254
    • Majchrowicz, E.1
  • 65
    • 0026511491 scopus 로고
    • Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia
    • Morioka T., Kalehua A.N., Streit W.J. Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia. Acta Neuropathol. 1992, 83:149-157.
    • (1992) Acta Neuropathol. , vol.83 , pp. 149-157
    • Morioka, T.1    Kalehua, A.N.2    Streit, W.J.3
  • 66
    • 77749308336 scopus 로고    scopus 로고
    • Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model
    • Morris S.A., Eaves D.W., Smith A.R., Nixon K. Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model. Hippocampus 2010, 20:596-607.
    • (2010) Hippocampus , vol.20 , pp. 596-607
    • Morris, S.A.1    Eaves, D.W.2    Smith, A.R.3    Nixon, K.4
  • 67
    • 76449083906 scopus 로고    scopus 로고
    • Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence
    • Morris S.A., Kelso M.L., Liput D.J., Marshall S.A., Nixon K. Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence. Alcohol 2010, 44:89-98.
    • (2010) Alcohol , vol.44 , pp. 89-98
    • Morris, S.A.1    Kelso, M.L.2    Liput, D.J.3    Marshall, S.A.4    Nixon, K.5
  • 68
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 69
    • 7444229099 scopus 로고    scopus 로고
    • Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol
    • Nixon K., Crews F.T. Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J. Neurosci. 2004, 24:9714-9722.
    • (2004) J. Neurosci. , vol.24 , pp. 9714-9722
    • Nixon, K.1    Crews, F.T.2
  • 70
    • 47149105823 scopus 로고    scopus 로고
    • Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis
    • Nixon K., Kim D.H., Potts E.N., He J., Crews F.T. Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis. Neurobiol. Dis. 2008, 31:218-229.
    • (2008) Neurobiol. Dis. , vol.31 , pp. 218-229
    • Nixon, K.1    Kim, D.H.2    Potts, E.N.3    He, J.4    Crews, F.T.5
  • 72
    • 0036123834 scopus 로고    scopus 로고
    • Binge ethanol exposure in adult rats causes necrotic cell death
    • Obernier J.A., Bouldin T.W., Crews F.T. Binge ethanol exposure in adult rats causes necrotic cell death. Alcohol. Clin. Exp. Res. 2002, 26:547-557.
    • (2002) Alcohol. Clin. Exp. Res. , vol.26 , pp. 547-557
    • Obernier, J.A.1    Bouldin, T.W.2    Crews, F.T.3
  • 74
    • 0036949032 scopus 로고    scopus 로고
    • Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: implications in neurological diseases
    • O'Keefe G.M., Nguyen V.T., Benveniste E.N. Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: implications in neurological diseases. J. Neurovirol. 2002, 8:496-512.
    • (2002) J. Neurovirol. , vol.8 , pp. 496-512
    • O'Keefe, G.M.1    Nguyen, V.T.2    Benveniste, E.N.3
  • 76
    • 0034880129 scopus 로고    scopus 로고
    • Effects of nicotine on ethanol dependence and brain damage
    • Penland S., Hoplight B., Obernier J., Crews F.T. Effects of nicotine on ethanol dependence and brain damage. Alcohol 2001, 24:45-54.
    • (2001) Alcohol , vol.24 , pp. 45-54
    • Penland, S.1    Hoplight, B.2    Obernier, J.3    Crews, F.T.4
  • 77
    • 0037315747 scopus 로고    scopus 로고
    • The impact of systemic infection on the progression of neurodegenerative disease
    • Perry V.H., Newman T.A., Cunningham C. The impact of systemic infection on the progression of neurodegenerative disease. Nat. Rev. Neurosci. 2003, 4:103-112.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 103-112
    • Perry, V.H.1    Newman, T.A.2    Cunningham, C.3
  • 79
    • 67649515340 scopus 로고    scopus 로고
    • Neuroprotection of microglial condition medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2
    • Polazzi E., Altamira L.E., Eleuteri S., Barbaro R., Casadio C., Contestabile A., Monti B. Neuroprotection of microglial condition medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2. J. Neurochem. 2009, 2:545-556.
    • (2009) J. Neurochem. , vol.2 , pp. 545-556
    • Polazzi, E.1    Altamira, L.E.2    Eleuteri, S.3    Barbaro, R.4    Casadio, C.5    Contestabile, A.6    Monti, B.7
  • 80
    • 84855482133 scopus 로고    scopus 로고
    • U.S. mortality from liver cirrhosis and alcoholic liver disease in 1999-2004: regional and state variation in relation to per capita alcohol consumption
    • Polednak A.P. U.S. mortality from liver cirrhosis and alcoholic liver disease in 1999-2004: regional and state variation in relation to per capita alcohol consumption. Subst. Use Misuse 2012, 47:202-213.
    • (2012) Subst. Use Misuse , vol.47 , pp. 202-213
    • Polednak, A.P.1
  • 81
    • 84862255818 scopus 로고    scopus 로고
    • Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    • Qin L., Crews F.T. Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration. J. Neuroinflammation 2012, 9:130.
    • (2012) J. Neuroinflammation , vol.9 , pp. 130
    • Qin, L.1    Crews, F.T.2
  • 82
    • 43149085744 scopus 로고    scopus 로고
    • Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    • Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J. Neuroinflammation 2008, 5:10.
    • (2008) J. Neuroinflammation , vol.5 , pp. 10
    • Qin, L.1    He, J.2    Hanes, R.N.3    Pluzarev, O.4    Hong, J.S.5    Crews, F.T.6
  • 83
    • 0033583924 scopus 로고    scopus 로고
    • Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis
    • Rabchevsky A.G., Degos J.D., Dreyfus P.A. Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis. Brain Res. 1999, 832:84-96.
    • (1999) Brain Res. , vol.832 , pp. 84-96
    • Rabchevsky, A.G.1    Degos, J.D.2    Dreyfus, P.A.3
  • 84
    • 0034660250 scopus 로고    scopus 로고
    • Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines
    • Rabuffetti M., Sciorati C., Tarozzo G., Clementi E., Manfredi A.A., Beltramo M. Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J. Neurosci. 2000, 20:4398-4404.
    • (2000) J. Neurosci. , vol.20 , pp. 4398-4404
    • Rabuffetti, M.1    Sciorati, C.2    Tarozzo, G.3    Clementi, E.4    Manfredi, A.A.5    Beltramo, M.6
  • 85
    • 0032814562 scopus 로고    scopus 로고
    • Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
    • Raivich G., Bohatschek M., Kloss C.U., Werner A., Jones L.L., Kreutzberg G.W. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res. Brain Res. Rev. 1999, 30:77-105.
    • (1999) Brain Res. Brain Res. Rev. , vol.30 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.U.3    Werner, A.4    Jones, L.L.5    Kreutzberg, G.W.6
  • 87
    • 78049450207 scopus 로고    scopus 로고
    • Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury
    • Readnower R.D., Chavko M., Adeeb S., Conroy M.D., Pauly J.R., McCarron R.M., Sullivan P.G. Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury. J. Neurosci. Res. 2010, 88:3530-3539.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 3530-3539
    • Readnower, R.D.1    Chavko, M.2    Adeeb, S.3    Conroy, M.D.4    Pauly, J.R.5    McCarron, R.M.6    Sullivan, P.G.7
  • 89
    • 0022654730 scopus 로고
    • Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3
    • Robinson A.P., White T.M., Mason D.W. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology 1986, 57:239-247.
    • (1986) Immunology , vol.57 , pp. 239-247
    • Robinson, A.P.1    White, T.M.2    Mason, D.W.3
  • 90
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K., Glass C.K. Microglial cell origin and phenotypes in health and disease. Nat. Rev. Immunol. 2012, 11:775-787.
    • (2012) Nat. Rev. Immunol. , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 91
    • 0027738727 scopus 로고
    • Regional patterns of blood-brain barrier breakdown following central and lateral fluid percussion injury in rodents
    • Schmidt R.H., Grady M.S. Regional patterns of blood-brain barrier breakdown following central and lateral fluid percussion injury in rodents. J. Neurotrauma 1993, 10:415-430.
    • (1993) J. Neurotrauma , vol.10 , pp. 415-430
    • Schmidt, R.H.1    Grady, M.S.2
  • 93
    • 79958813517 scopus 로고    scopus 로고
    • Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances
    • Seth D., Haber P.S., Syn W.K., Diehl A.M., Day C.P. Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J. Gastroenterol. Hepatol. 2011, 26:1089-1105.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 1089-1105
    • Seth, D.1    Haber, P.S.2    Syn, W.K.3    Diehl, A.M.4    Day, C.P.5
  • 94
    • 79151475898 scopus 로고    scopus 로고
    • IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways
    • Sharma S., Yang B., Xi X., Grotta J.C., Aronowski J., Savitz S.I. IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. Brain Res. 2011, 1373:189-194.
    • (2011) Brain Res. , vol.1373 , pp. 189-194
    • Sharma, S.1    Yang, B.2    Xi, X.3    Grotta, J.C.4    Aronowski, J.5    Savitz, S.I.6
  • 97
    • 0032921821 scopus 로고    scopus 로고
    • Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice
    • Sparks J.A., Pauly J.R. Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice. Psychopharmacology (Berl) 1999, 141:145-153.
    • (1999) Psychopharmacology (Berl) , vol.141 , pp. 145-153
    • Sparks, J.A.1    Pauly, J.R.2
  • 98
    • 84886949297 scopus 로고    scopus 로고
    • Endogenous transforming growth factor-beta promotes quiescence of primary microgli in vitro
    • Spittau B., Wullkopf L., Zhou X., Rilka J., Pfeifer D., Krieglstein K. Endogenous transforming growth factor-beta promotes quiescence of primary microgli in vitro. Glia 2012, 12.
    • (2012) Glia , vol.12
    • Spittau, B.1    Wullkopf, L.2    Zhou, X.3    Rilka, J.4    Pfeifer, D.5    Krieglstein, K.6
  • 99
    • 0029047144 scopus 로고
    • Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat
    • Stephenson D.T., Schober D.A., Smalstig E.B., Mincy R.E., Gehlert D.R., Clemens J.A. Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J. Neurosci. 1995, 15:5263-5274.
    • (1995) J. Neurosci. , vol.15 , pp. 5263-5274
    • Stephenson, D.T.1    Schober, D.A.2    Smalstig, E.B.3    Mincy, R.E.4    Gehlert, D.R.5    Clemens, J.A.6
  • 100
    • 0033624408 scopus 로고    scopus 로고
    • Cytokines in CNS disorders: neurotoxicity versus neuroprotection
    • Stoll G., Jander S., Schroeter M. Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J. Neural Transm. 2000, 81-89.
    • (2000) J. Neural Transm. , pp. 81-89
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 101
    • 0010635310 scopus 로고
    • Microglia in the pathological brain
    • (Report nr 94-3742)
    • Streit W.J. Microglia in the pathological brain. Nat. Inst. Alcohol Abuse Alcohol. 1994, 55-68. (Report nr 94-3742).
    • (1994) Nat. Inst. Alcohol Abuse Alcohol. , pp. 55-68
    • Streit, W.J.1
  • 103
    • 33947492321 scopus 로고    scopus 로고
    • Roles of glia-derived cytokines on neuronal degeneration and regeneration
    • Suzumura A., Takeuchi H., Zhang G., Kuno R., Mizuno T. Roles of glia-derived cytokines on neuronal degeneration and regeneration. Ann. N. Y. Acad. Sci. 2006, 1088:219-229.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1088 , pp. 219-229
    • Suzumura, A.1    Takeuchi, H.2    Zhang, G.3    Kuno, R.4    Mizuno, T.5
  • 104
    • 0023868632 scopus 로고
    • Chronic ethanol exposure increases peripheral-type benzodiazepine receptors in brain
    • Syapin P.J., Alkana R.L. Chronic ethanol exposure increases peripheral-type benzodiazepine receptors in brain. Eur. J. Pharmacol. 1988, 147:101-109.
    • (1988) Eur. J. Pharmacol. , vol.147 , pp. 101-109
    • Syapin, P.J.1    Alkana, R.L.2
  • 105
    • 0016192339 scopus 로고
    • "Binge" and continuous drinkers. Characteristics and treatment follow-up
    • Tomsovic M. "Binge" and continuous drinkers. Characteristics and treatment follow-up. Q. J. Stud. Alcohol 1974, 35:558-564.
    • (1974) Q. J. Stud. Alcohol , vol.35 , pp. 558-564
    • Tomsovic, M.1
  • 106
    • 80054905220 scopus 로고    scopus 로고
    • A role for microglia in synaptic plasticity?
    • Tremblay M.E., Majewska A.K. A role for microglia in synaptic plasticity?. Commun. Integr. Biol. 2011, 4:220-222.
    • (2011) Commun. Integr. Biol. , vol.4 , pp. 220-222
    • Tremblay, M.E.1    Majewska, A.K.2
  • 107
    • 0001120209 scopus 로고
    • Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein
    • Triguero D., Buciak J.B., Yang J., Pardridge W.M. Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:4761-4765.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 4761-4765
    • Triguero, D.1    Buciak, J.B.2    Yang, J.3    Pardridge, W.M.4
  • 108
    • 8744309183 scopus 로고    scopus 로고
    • Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes
    • Valles S.L., Blanco A.M., Pascual M., Guerri C. Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol. 2004, 14:365-371.
    • (2004) Brain Pathol. , vol.14 , pp. 365-371
    • Valles, S.L.1    Blanco, A.M.2    Pascual, M.3    Guerri, C.4
  • 109
    • 34648828256 scopus 로고    scopus 로고
    • Translocator protein 18kDa is involved in the regulation of reactive gliosis
    • Veiga S., Carrero P., Pernia O., Azcoitia I., Garcia-Segura L.M. Translocator protein 18kDa is involved in the regulation of reactive gliosis. Glia 2007, 55:1426-1436.
    • (2007) Glia , vol.55 , pp. 1426-1436
    • Veiga, S.1    Carrero, P.2    Pernia, O.3    Azcoitia, I.4    Garcia-Segura, L.M.5
  • 110
    • 4644308783 scopus 로고    scopus 로고
    • Microglia: phagocyte and glia cell
    • Vilhardt F. Microglia: phagocyte and glia cell. Int. J. Biochem. Cell Biol. 2005, 37:17-21.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 17-21
    • Vilhardt, F.1
  • 111
    • 3543027426 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature
    • Vitarbo E.A., Chatzipanteli K., Kinoshita K., Truettner J.S., Alonso O.F., Dietrich W.D. Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature. Neurosurgery 2004, 55:416-424.
    • (2004) Neurosurgery , vol.55 , pp. 416-424
    • Vitarbo, E.A.1    Chatzipanteli, K.2    Kinoshita, K.3    Truettner, J.S.4    Alonso, O.F.5    Dietrich, W.D.6
  • 114
    • 70350654793 scopus 로고    scopus 로고
    • Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content
    • Ward R.J., Colivicchi M.A., Allen R., Schol F., Lallemand F., de Witte P., Ballini C., Corte L.D., Dexter D. Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content. J. Neurochem. 2009, 111:1119-1128.
    • (2009) J. Neurochem. , vol.111 , pp. 1119-1128
    • Ward, R.J.1    Colivicchi, M.A.2    Allen, R.3    Schol, F.4    Lallemand, F.5    de Witte, P.6    Ballini, C.7    Corte, L.D.8    Dexter, D.9
  • 115
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., Gundersen H.J.G. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 1991, 231:482-497.
    • (1991) Anat. Rec. , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.G.3
  • 117
    • 0025820808 scopus 로고
    • Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
    • Woodroofe M.N., Sarna G.S., Wadhwa M., Hayes G.M., Loughlin A.J., Tinker A., Cuzner M.L. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 1991, 33:227-236.
    • (1991) J. Neuroimmunol. , vol.33 , pp. 227-236
    • Woodroofe, M.N.1    Sarna, G.S.2    Wadhwa, M.3    Hayes, G.M.4    Loughlin, A.J.5    Tinker, A.6    Cuzner, M.L.7
  • 118
    • 78049300507 scopus 로고    scopus 로고
    • Measurement of serum, liver, and brain cytokine induction, thiamine levels, and hepatopathology in rats exposed to a 4-day alcohol binge protocol
    • Zahr N.M., Luong R., Sullivan E.V., Pfefferbaum A. Measurement of serum, liver, and brain cytokine induction, thiamine levels, and hepatopathology in rats exposed to a 4-day alcohol binge protocol. Alcohol. Clin. Exp. Res. 2010, 34:1858-1870.
    • (2010) Alcohol. Clin. Exp. Res. , vol.34 , pp. 1858-1870
    • Zahr, N.M.1    Luong, R.2    Sullivan, E.V.3    Pfefferbaum, A.4
  • 119
    • 80355125158 scopus 로고    scopus 로고
    • CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
    • Zhang S., Wang X.J., Tian L.P., Pan J., Lu G.Q., Zhang Y.J., Ding J.Q., Chen S.D. CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease. J. Neuroinflammation 2011, 8:154.
    • (2011) J. Neuroinflammation , vol.8 , pp. 154
    • Zhang, S.1    Wang, X.J.2    Tian, L.P.3    Pan, J.4    Lu, G.Q.5    Zhang, Y.J.6    Ding, J.Q.7    Chen, S.D.8


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