Building blood vessels in development and disease

Current Opinion in Hematology

Volumn 20, Issue 3, 2013, Pages 231-236

  Kushner, Erich J ^a   Bautch, Victoria L ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; blood vessel development; cancer; tumor endothelial cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN; G PROTEIN COUPLED RECEPTOR; METHYLTRANSFERASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN 1; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; PACLITAXEL; PROTEIN P53; VANILLOID RECEPTOR 4; VASCULOTROPIN A;

ANGIOGENESIS; APOPTOSIS; CELL FUNCTION; CELL MIGRATION; CENTROSOME; DNA DAMAGE; DNA MODIFICATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; EPIGENETICS; EXTRAVASATION; GENE DELETION; GENE REARRANGEMENT; GENETIC DIFFERENCE; HISTONE MODIFICATION; HUMAN; INTRACELLULAR SIGNALING; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ENDOTHELIAL CELLS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876297676     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328360614b     Document Type: Review

References (59)

1. Cleaver O, Krieg PA. Molecular mechanisms of vascular development. In: Harvey RP, Rosenthal N, editors. Heart development. San Diego: Academic Press; 1999. pp. 221-252.
2. Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature 2005; 438:937-945. (Pubitemid 43093959)
3. Risau W. Mechanisms of angiogenesis. Nature 1997; 386:671-674. (Pubitemid 27193480)
4. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-676. (Pubitemid 36749215)
5. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling: in control of vascular function. Nat Rev Mol Cell Biol 2006; 7:359-371.
6. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435-439. (Pubitemid 26102719)
7. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380:439-442. (Pubitemid 26102720)
8. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376:66-70.
9. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995; 376:62-66.
10. Ruhrberg C, Gerhardt H, Golding M, et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 2002; 16:2684-2698.
11. Stalmans I, Ng Y-S, Rohan R, et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest 2002; 109:327-336. (Pubitemid 34141806)
12. Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 1993; 90:10705-10709. (Pubitemid 23347111)
13. Chappell JC, Taylor SM, Ferrara N, Bautch VL. Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev Cell 2009; 17:377-386.
14. Kearney JB, Ambler CA, Monaco KA, et al. Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 2002; 99:2397-2407. (Pubitemid 34525425)
15. Kearney JB, Kappas NC, Ellerstrom C, et al. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood 2004; 103:4527-4535. (Pubitemid 38745980)
16. Roberts DM, Kearney JB, Johnson JH, et al. The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am J Pathol 2004; 164:1531-1535. (Pubitemid 38529755)
17. Gerhardt H, Golding M, Fruttiger M, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003; 161:1163-1177. (Pubitemid 36870177)
18. Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007; 445:776-780. (Pubitemid 46279716)
19. Leslie JD, Ariza-McNaughton L, Bermange AL, et al. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 2007; 134:839-844. (Pubitemid 46795675)
20. Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 2007; 445:781-784. (Pubitemid 46279717)
21. Suchting S, Freitas C, le Noble F, et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci USA 2007; 104:3225-3230. (Pubitemid 46364141)
22. Jakobsson L, Franco CA, Bentley K, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol 2010; 12:943-953.
23. Dejana E. The Role of Wnt signaling in physiological and pathological angiogenesis. Circ Res 2010; 107:943-952.
24. David L, Feige J-J, Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev 2009; 20:203-212.
25. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-478. (Pubitemid 46823443)
26. Wiley DM, Kim JD, Hao JJ, et al. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol 2011; 13:686-692.
27. Larrivee B, Prahst C, Gordon E, et al. ALK1 signaling inhibits angiogenesis by cooperating with the notch pathway. Dev Cell 2012; 22:489-500.
28. Moya IM, Umans L, Maas E, et al. Stalk cell phenotype depends on integration of notch and smad1/5 signaling cascades. Dev Cell 2012; 22:501-514.
29. Kim J, Oh W-J, Gaiano N, et al. Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev 2011; 25:1399-1411.
30. Torres-Vazquez J, Gitler AD, Fraser SD, et al. Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell 2004; 7:117-123. (Pubitemid 39172693)
31. Gaenge K, Niaudet C, Hagikura K, et al. The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell 2012; 23:587-599.
32. Jung B, Obinata H, Galvani S, et al. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell 2012; 23:600-610.
33. Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000; 106:951-961.
34. Shoham AB, Malkinson G, Krief S, et al. S1P1 inhibits sprouting angiogenesis during vascular development. Development 2012; 139:3859-3869.
35. Saharinen P, Bry M, Alitalo K. How do angiopoietins tie with vascular endothelial growth factors? Curr Opin Hematol 2010; 17:198-205.
36. Armulik A, Genove G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011; 21:193-215.
37. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-364. (Pubitemid 26272076)
38. De Bock K, Cauwenberghs S, Carmeliet P. Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications. Curr Opin Genet Dev 2011; 21:73-79.
39. Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136:839-851.
40. Liu W, Ahmad SA, Reinmuth N, et al. Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis 2000; 5:323-328.
41. Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nature 2011; 10:417-427.
42. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011; 473:298-307.
43. Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM. Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol 2010; 26:315-333.
44. Guilluy C, Garcia-Mata R, Burridge K. Rho protein crosstalk: another social network? Trends Cell Biol 2011; 21:718-726.
45. Ghosh K, Thodeti CK, Dudley AC, et al. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci USA 2008; 105:11305-11310.
46. Fiorio Pla A, Ong HL, Cheng KT, et al. TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling. Oncogene 2012; 31:200-212.
47. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-674.
48. Hida K, Hida Y, Amin DN, et al. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 2004; 64:8249-8255. (Pubitemid 39491762)
49. Akino T, Hida K, Hida Y, et al. Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors. Am J Pathol 2009; 175:2657-2667.
50. Dudley AC, Shih SC, Cliffe AR, et al. Attenuated p53 activation in tumourassociated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer 2008; 99:118-125. (Pubitemid 351920247)
51. Dudley AC, Udagawa T, Melero-Martin JM, et al. Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood 2010; 116:3367-3371.
52. Griffioen AW, Damen CA, Martinotti S, et al. Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res 1996; 56:1111-1117. (Pubitemid 26065408)
53. Bussolati B, Deambrosis I, Russo S, et al. Altered angiogenesis and survival in human tumor-derived endothelial cells. Faseb J 2003; 17:1159-1161.
54. Bussolati B, Grange C, Bruno S, et al. Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillary-like structures. Exp Cell Res 2006; 312:913-924.
55. Matsuda K, Ohga N, Hida Y, et al. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Comm 2010; 394:947-954.
56. Taylor SM, Nevis KR, Park HL, et al. Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood 2010; 116:3108-3117.
57. Ohga N, Ishikawa S, Maishi N, et al. Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high-and lowmetastatic tumors. Am J Pathol 2012; 180:1294-1307.
58. Akiyama K, Ohga N, Hida Y, et al. Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment. Am J Pathol 2012; 180:1283-1293.
59. Chung I, Karpf AR, Muindi JR, et al. Epigenetic silencing of CYP24 in tumorderived endothelial cells contributes to selective growth inhibition by calcitriol. J Biol Chem 2007; 282:8704-8714. (Pubitemid 47093535)