Peroxisome proliferator-activated receptor delta agonist attenuates nicotine suppression effect on human mesenchymal stem cell-derived osteogenesis and involves increased expression of heme oxygenase-1

Journal of Bone and Mineral Metabolism

Volumn 31, Issue 1, 2013, Pages 44-52

  Kim, Dong Hyun ^a   Liu, Jiayong ^b   Bhat, Samerna ^b   Benedict, Gregory ^b   Lecka Czernik, Beata ^a,b   Peterson, Stephen J ^c   Ebraheim, Nabil A ^b   Heck, Bruce E ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF TOLEDO MEDICAL CENTER   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

HO 1; Nicotine; Osteogenesis; PPAR

Indexed keywords

[4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; ALKALINE PHOSPHATASE; BETA ACTIN; BONE MORPHOGENETIC PROTEIN 2; HEME OXYGENASE 1; NICOTINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST;

ARTICLE; BONE DEVELOPMENT; BONE REMODELING; CALCIUM DEPLETION; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLASTIC DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALKALINE PHOSPHATASE; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; BONE REMODELING; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMANS; MESENCHYMAL STROMAL CELLS; NICOTINE; NICOTINIC AGONISTS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; PPAR DELTA; SMOKING; THIAZOLES;

EID: 84876282648     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-012-0382-0     Document Type: Article

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