GW0742, a high-affinity PPAR-δ agonist, mediates protection in an organotypic model of spinal cord damage

Spine

Volumn 37, Issue 2, 2012, Pages

  Esposito, Emanuela ^a   Paterniti, Irene ^a   Meli, Rosaria ^b   Bramanti, Placido ^c   Cuzzocrea, Salvatore ^a,c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

Author keywords

organotypic cultures; PPAR ; spinal cord

Indexed keywords

[4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOOXYGENASE 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; MOLECULAR INTERACTION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

ANIMALS; MICE; MODELS, BIOLOGICAL; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PPAR DELTA; PROTEIN ISOFORMS; SPINAL CORD; SPINAL CORD INJURIES; THIAZOLES;

EID: 84855430333     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182276d88     Document Type: Article

References (27)

1. Hihi AK, Michalik L, Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 2002; 59: 790-8. (Pubitemid 34628240)
2. Tan NS, Icre G, Montagner A, et al. The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration. Mol Cell Biol 2007; 27: 7161-75. (Pubitemid 47549752)
3. Nadra K, Anghel SI, Joye E, et al. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol 2006; 26: 3266-81.
4. Matsusue K, Peters JM, Gonzalez FJ. PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation. FASEB J 2004; 18: 1477-9. (Pubitemid 39561620)
5. Kim DJ, Prabhu KS, Gonzalez FJ, et al. Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Carcinogenesis 2006; 27: 1105-12.
6. Muller-Brusselbach S, Ebrahimsade S, Jakel J, et al. Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. Int J Oncol 2007; 31: 607-11.
7. Benani A, Heurtaux T, Netter P, et al. Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation. Neurosci Lett 2004; 369: 59-63. (Pubitemid 39369503)
8. Hall MG, Quignodon L, Desvergne B. Peroxisome proliferator-activated receptor beta/delta in the brain: facts and hypothesis. PPAR Res 2008;2008:780452.
9. Braissant O, Wahli W. Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998; 139: 2748-54. (Pubitemid 28512383)
10. Peters JM, Lee SS, Li W, et al. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse per-oxisome proliferator-activated receptor beta(delta). Mol Cell Biol 2000; 20: 5119-28. (Pubitemid 30431565)
11. Saluja I, Granneman JG, Skoff RP. PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture. Glia 2001; 33: 191-204. (Pubitemid 32219128)
12. Zai LJ, Wrathall JR. Cell proliferation and replacement following contusive spinal cord injury. Glia 2005; 50: 247-57. (Pubitemid 40769854)
13. Polak PE, Kalinin S, Dello Russo C, et al. Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol 2005; 168: 65-75. (Pubitemid 41396404)
14. Moya-Camarena SY, Van den Heuvel JP, Belury MA. Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta 1999; 1436: 331-42. (Pubitemid 29242914)
15. Madrigal JL, Kalinin S, Richardson JC, et al. Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta. J Neurochem 2007; 103: 2092-101. (Pubitemid 350126619)
16. Iwashita A, Muramatsu Y, Yamazaki T, et al. Neuroprotective effi cacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo. J Pharmacol Exp Ther 2007; 320: 1087-96. (Pubitemid 46294065)
17. Abe K, Matsuki N. Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neurosci Res 2000; 38: 325-9. (Pubitemid 32063338)
18. Woods JW, Tanen M, Figueroa DJ, et al. Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons. Brain Res 2003; 975: 10-21. (Pubitemid 36588548)
19. Paterniti I, Esposito E, Mazzon E, et al. Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury. J Pharmacol Exp Ther 2010; 333: 465-77.
20. Matsuura H, Adachi H, Smart RC, et al. Correlation between expression of peroxisome proliferator-activated receptor beta and squamous differentiation in epidermal and tracheobronchial epithelial cells. Mol Cell Endocrinol 1999; 147: 85-92. (Pubitemid 29090396)
21. Welch JS, Ricote M, Akiyama TE, et al. PPARgamma and PPARdelta negatively regulate specifi c subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 2003; 100: 6712-17. (Pubitemid 36666645)
22. Ding G, Cheng L, Qin Q, et al. PPARdelta modulates lipopolysaccharide- induced TNFalpha infl ammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol 2006; 40: 821-8. (Pubitemid 43817042)
23. Kapoor A, Collino M, Castiglia S, et al. Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat. Shock 2010; 34: 117-24.
24. Adamchik Y, Frantseva MV, Weisspapir M, et al. Methods to induce primary and secondary traumatic damage in organotypic hippo-campal slice cultures. Brain Res Brain Res Protoc 2000; 5: 153-8. (Pubitemid 30210033)
25. Delfs J, Friend J, Ishimoto S, et al. Ventral and dorsal horn acetyl-cholinesterase neurons are maintained in organotypic cultures of postnatal rat spinal cord explants. Brain Res 1989; 488: 31-42.
26. Marsh DR, Dekaban GA, Tan W, et al. Herpes simplex viral and amplicon vector-mediated gene transfer into glia and neurons in organotypic spinal cord and dorsal root ganglion cultures. Mol Ther 2000; 1: 464-78.
27. Kerkut GA, Bagust J. The isolated mammalian spinal cord. Prog Neurobiol 1995; 46: 1-48.