메뉴 건너뛰기




Volumn 26, Issue 4, 2013, Pages 245-253

The pathophysiology and pharmacological treatment of Huntington disease

Author keywords

Chorea; dopamine; Huntington disease; non motor symptoms; pharmacotherapy; tetrabenazine

Indexed keywords

AMANTADINE; ATOMOXETINE; ATYPICAL ANTIPSYCHOTIC AGENT; BACLOFEN; CLOZAPINE; DIMEBON; DONEPEZIL; DOPAMINE 2 RECEPTOR BLOCKING AGENT; FLUOXETINE; MODAFINIL; NABILONE; NEUROLEPTIC AGENT; PLACEBO; REMACEMIDE; RILUZOLE; SEROTONIN UPTAKE INHIBITOR; TETRABENAZINE; TIAPRIDE; UBIDECARENONE;

EID: 84876280381     PISSN: 09534180     EISSN: 18758584     Source Type: Journal    
DOI: 10.1155/2013/705373     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 41249096422 scopus 로고    scopus 로고
    • Symptomatic Treatment of Huntington Disease
    • DOI 10.1016/j.nurt.2008.01.008, PII S1933721308000093
    • O.R. Adam and J. Jankovic, Symptomatic treatment of Huntington disease, Neurotherapeutics 5 (2008), 181-197. (Pubitemid 351446213)
    • (2008) Neurotherapeutics , vol.5 , Issue.2 , pp. 181-197
    • Adam, O.R.1    Jankovic, J.2
  • 2
    • 78650031174 scopus 로고    scopus 로고
    • Huntington's disease: From molecular pathogenesis to clinical treatment
    • C.A. Ross and S.J. Tabrizi, Huntington's disease: from molecular pathogenesis to clinical treatment, Lancet Neurol 10 (2011), 83-98.
    • (2011) Lancet Neurol , vol.10 , pp. 83-98
    • Ross, C.A.1    Tabrizi, S.J.2
  • 3
    • 0021028244 scopus 로고
    • A polymorphic DNA marker genetically linked to Huntington's disease
    • J.F. Gusella, N.S. Wexler, P.M. Conneally, S.L. Naylor, M.A. Anderson, R.E. Tanzi et al., A polymporphic DNA marker genetically linker to Huntington's disease, Nature 306 (1983), 234-238. (Pubitemid 14232350)
    • (1983) Nature , vol.306 , Issue.5940 , pp. 234-238
    • Gusella, J.F.1    Wexler, N.S.2    Conneally, P.M.3
  • 4
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes, Cell 72 (1993), 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 5
    • 53049084348 scopus 로고    scopus 로고
    • The current clinical management of Huntington's disease
    • W. Philips, K.M. Shannon and R.A. Barker, The current clinical management of Huntington's disease, Mov Disord 23 (2008), 1491-1504.
    • (2008) Mov Disord , vol.23 , pp. 1491-1504
    • Philips, W.1    Shannon, K.M.2    Barker, R.A.3
  • 6
    • 68249113963 scopus 로고    scopus 로고
    • Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: Cross sectional analysis of baseline data
    • S.J. Tabrizi, D.R. Langbehn, B.R. Leavitt, R.A.C. Roos, A. Durr, D. Crauford et al., Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross sectional analysis of baseline data, Lancet Neurol 8 (2009), 791-801.
    • (2009) Lancet Neurol , vol.8 , pp. 791-801
    • Tabrizi, S.J.1    Langbehn, D.R.2    Leavitt, B.R.3    Roos, R.A.C.4    Durr, A.5    Crauford, D.6
  • 9
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • DOI 10.1016/S0140-6736(07)60111-1, PII S0140673607601111
    • F.O. Walker, Huntington's disease, Lancet 369 (2007), 218-228. (Pubitemid 46107685)
    • (2007) Lancet , vol.369 , Issue.9557 , pp. 218-228
    • Walker, F.O.1
  • 10
    • 36048940046 scopus 로고    scopus 로고
    • Tetrabenazine in the treatment of Huntington's disease
    • D. Paleacu, Tetrabenazine in the treatment of Huntington's disease, Neuropsychiatr Dis Treat 3 (2007), 545-551. (Pubitemid 350090285)
    • (2007) Neuropsychiatric Disease and Treatment , vol.3 , Issue.5 , pp. 545-551
    • Paleacu, D.1
  • 11
    • 78650228452 scopus 로고    scopus 로고
    • Huntington's disease: From molecular basis to therapeutic advances
    • S. Krobitsch and A.G. Kazantsev, Huntington's disease: from molecular basis to therapeutic advances, Int J Biochem Cell B 43 (2010), 20-24.
    • (2010) Int J Biochem Cell B , vol.43 , pp. 20-24
    • Krobitsch, S.1    Kazantsev, A.G.2
  • 12
    • 33846654677 scopus 로고    scopus 로고
    • Huntington's disease-making connections
    • J.T. Greenamyre, Huntington's disease-making connections, N Engl J Med 365 (2007), 518-529.
    • (2007) N Engl J Med , vol.365 , pp. 518-529
    • Greenamyre, J.T.1
  • 13
    • 52049085768 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: From huntingtin functions to potential treatment
    • E. Roze, F. Saudou and J. Caboche, Pathophysiology of Huntington's disease: from huntingtin functions to potential treatment, Curr Opin Neurol 21 (2008), 497-503.
    • (2008) Curr Opin Neurol , vol.21 , pp. 497-503
    • Roze, E.1    Saudou, F.2    Caboche, J.3
  • 14
    • 79951974420 scopus 로고    scopus 로고
    • Tetrabenazine: The first approved drug for the treatment if chorea in US patients with Huntington disease
    • S. Frank, Tetrabenazine: the first approved drug for the treatment if chorea in US patients with Huntington disease, Neuropsychiatr Dis Treat 6 (2010), 657-665.
    • (2010) Neuropsychiatr Dis Treat , vol.6 , pp. 657-665
    • Frank, S.1
  • 15
    • 27344447235 scopus 로고    scopus 로고
    • The therapeutic role of creatine in Huntington's disease
    • DOI 10.1016/j.pharmthera.2005.04.008, PII S0163725805001233
    • H. Ryu, H.D. Rosas, S.M. Hersch and R.J. Ferrante, The therapeutic role of creatine in Huntington's disease, Pharmacol Therapeut 108 (2005), 193-207. (Pubitemid 41527084)
    • (2005) Pharmacology and Therapeutics , vol.108 , Issue.2 , pp. 193-207
    • Ryu, H.1    Rosas, H.D.2    Hersch, S.M.3    Ferrante, R.J.4
  • 16
    • 0036704933 scopus 로고    scopus 로고
    • Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update
    • DOI 10.1016/S0022-3999(02)00428-2, PII S0022399902004282
    • S. Tekin and J.L. Cummings, Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update, J Psychosom Res 53 (2002), 647-654. (Pubitemid 36292444)
    • (2002) Journal of Psychosomatic Research , vol.53 , Issue.2 , pp. 647-654
    • Tekin, S.1    Cummings, J.L.2
  • 17
    • 0032934931 scopus 로고    scopus 로고
    • Huntington's disease: Options for controlling symptoms
    • J.P.P. van Vugt and R.A.C. Roos, Huntington's disease: options for controlling symptoms, CNS Drugs 11 (1999), 105-123. (Pubitemid 29113639)
    • (1999) CNS Drugs , vol.11 , Issue.2 , pp. 105-123
    • Van Vugt, J.P.P.1    Roos, R.A.C.2
  • 18
    • 77952135272 scopus 로고    scopus 로고
    • Dopamine and glutamate in Huntington's disease: A balancing act
    • V.M. Andre, C. Cepeda and M. Levine, Dopamine and glutamate in Huntington's disease: a balancing act, CNS Neurosci Ther 16 (2010), 163-178.
    • (2010) CNS Neurosci Ther , vol.16 , pp. 163-178
    • Andre, V.M.1    Cepeda, C.2    Levine, M.3
  • 19
    • 34447547513 scopus 로고    scopus 로고
    • Frontal-subcortical circuitry and behaviour
    • R.M. Bonelli and J.L.Cummings, Frontal-subcortical circuitry and behaviour, Dialogues Clin Neurosci 9 (2007), 141-151.
    • (2007) Dialogues Clin Neurosci , vol.9 , pp. 141-151
    • Bonelli, R.M.1    Cummings, J.L.2
  • 20
    • 58449103121 scopus 로고    scopus 로고
    • A systematic review of the treatment studies in Huntington's disease since 1990
    • R. Bonelli and P. Hofmann, A systematic review of the treatment studies in Huntington's disease since 1990, Expert Opin Pharmacother 7 (2007), 1-13.
    • (2007) Expert Opin Pharmacother , vol.7 , pp. 1-13
    • Bonelli, R.1    Hofmann, P.2
  • 21
    • 69149107165 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • D. Moher, A. Liberati, J. Tetzlaff and D.G. Altman, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Ann Intern Med 151 (2009), 264-269.
    • (2009) Ann Intern Med , vol.151 , pp. 264-269
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 23
    • 33645798913 scopus 로고    scopus 로고
    • Tetrabenazine as antichorea therapy in Huntington disease: A randomised control trial
    • Huntington Study Group
    • Huntington Study Group, Tetrabenazine as antichorea therapy in Huntington disease: a randomised control trial, Neurology 66 (2006), 366-372.
    • (2006) Neurology , vol.66 , pp. 366-372
  • 25
    • 0021733679 scopus 로고
    • Tiapride versus placebo: A double-blind comparative study in tha management of Huntington's chorea
    • J. Deroover, F. Baro, R.P. Bourguignon and P. Smets, Tiapride versus placebo: a double-blind comparative study in the management ofHuntington's chorea, Curr Med Res Opin 9 (1984), 329-338. (Pubitemid 15180157)
    • (1984) Current Medical Research and Opinion , vol.9 , Issue.5 , pp. 329-338
    • Deroover, J.1    Baro, F.2    Bourguignon, R.P.3    Smets, P.4
  • 26
    • 0020084322 scopus 로고
    • Tiapride in the treatment of Huntington's chorea
    • R.A.C. Roos, O.J.S. Buruma, G.W. Bruyn, B. Kemp and E.A. van deVelde, Tiapride in the treatment of Huntington's chorea, Acta Neurol Scand 65 (1982), 45-50. (Pubitemid 12178846)
    • (1982) Acta Neurologica Scandinavica , vol.65 , Issue.1 , pp. 45-50
    • Roos, R.A.C.1    Buruma, O.J.S.2    Bruyn, G.W.3
  • 27
    • 77957986360 scopus 로고    scopus 로고
    • Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease
    • A. Lundin, E. Dietrichs, S. Haghighi,M.L.Goller, A. Heiberg, G. Loutfi et al., Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease, Clin Neuropharm 33 (2010), 260-264.
    • (2010) Clin Neuropharm , vol.33 , pp. 260-264
    • Lundin, A.1    Dietrichs, E.2    Haghighi, S.3    Goller, M.L.4    Heiberg, A.5    Loutfi, G.6
  • 28
    • 0037056392 scopus 로고    scopus 로고
    • Huntington's disease: A randomised, controlled trial using the NMDA-antagonist amantadine
    • L. Verhagen-Metman, M.J. Morris, C. Farmer, N.P. Gillespie, K. Mosby, J. Wuu et al., Huntington's disease: a randomised, controlled trial using the NMDA-antagonist amantadine, Neurology 59 (2002), 694-699.
    • (2002) Neurology , vol.59 , pp. 694-699
    • Verhagen-Metman, L.1    Morris, M.J.2    Farmer, C.3    Gillespie, N.P.4    Mosby, K.5    Wuu, J.6
  • 29
    • 0038375825 scopus 로고    scopus 로고
    • A randomized trial of amantadine in Huntington disease
    • DOI 10.1001/archneur.60.7.996
    • P. O'Suilleabhain and R.B. Dewey, A randomised trial of amantadine in Huntington disease, Arch Neurol 60 (2003), 996-998. (Pubitemid 36858360)
    • (2003) Archives of Neurology , vol.60 , Issue.7 , pp. 996-998
    • O'Suilleabhain, P.1    Dewey Jr., R.B.2
  • 31
    • 85009226418 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
    • Huntington Study Group
    • Huntington Study Group, A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease, Neurology 57 (2001), 397-404.
    • (2001) Neurology , vol.57 , pp. 397-404
  • 33
    • 0345600893 scopus 로고    scopus 로고
    • Dosage effects if riluzole in Huntington's disease: A multicentre placebo-controlled study
    • Huntington Study Group
    • Huntington Study Group, Dosage effects if riluzole in Huntington's disease: a multicentre placebo-controlled study, Neurology 61 (2003), 1551-1556.
    • (2003) Neurology , vol.61 , pp. 1551-1556
  • 35
    • 33749861388 scopus 로고    scopus 로고
    • Effect of donepezil on motor and cognitive function in Huntington disease
    • DOI 10.1212/01.wnl.0000238106.10423.00, PII 0000611420061010000034
    • E. Cubo, K.M. Shannon, D. Tracy, J.A. Jaglin, B.A. Bernard, J. Wuu et al., Effect of donepezil onmotor and cognitive function in Huntington disease, Neurology 67 (2006), 1268-1271. (Pubitemid 44563842)
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1268-1271
    • Cubo, E.1    Shannon, K.M.2    Tracy, D.3    Jaglin, J.A.4    Bernard, B.A.5    Wuu, J.6    Leurgans, S.E.7
  • 37
    • 72849149551 scopus 로고    scopus 로고
    • A pilot study using nabilone for symptomatic treatment in Huntington's disease
    • A. Curtis, I. Mitchell, S. Patel, N. Ives and H. Rickards, A pilot study using nabilone for symptomatic treatment in Huntington's disease, Mov Disord 24 (2009), 2254-2259.
    • (2009) Mov Disord , vol.24 , pp. 2254-2259
    • Curtis, A.1    Mitchell, I.2    Patel, S.3    Ives, N.4    Rickards, H.5
  • 40
    • 61449249687 scopus 로고    scopus 로고
    • Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease
    • Huntington Study Group TREND-HD Investigators
    • Huntington Study Group TREND-HD Investigators. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease, Arch Neurol 65 (2008), 1582-1589.
    • (2008) Arch Neurol , vol.65 , pp. 1582-1589
  • 45
    • 78149469196 scopus 로고    scopus 로고
    • Treatment of irritability in Huntington's disease
    • E. van Duijn, Treatment of irritability in Huntington's disease, Curr Treat Option Neurol 12 (2010), 424-433.
    • (2010) Curr Treat Option Neurol , vol.12 , pp. 424-433
    • Van Duijn, E.1
  • 46
    • 33745759912 scopus 로고    scopus 로고
    • Pharmacological management of Huntington's disease: And evidence-based review
    • R.M. Bonelli and G.K. Wenning, Pharmacological management of Huntington's disease: and evidence-based review, Curr Pharm Des 12 (2006), 2701-2720.
    • (2006) Curr Pharm des , vol.12 , pp. 2701-2720
    • Bonelli, R.M.1    Wenning, G.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.