Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway

Oncology Reports

Volumn 29, Issue 6, 2013, Pages 2109-2113

  Jung, Chan Hun ^a   Kim, Eun Mi ^a   Park, Jong Kuk ^a   Hwang, Sang Gu ^a   Moon, Sung Kwon ^b   Kim, Wun Jae ^c   Um, Hong Duck ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Chungju National University   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

Author keywords

Bcl w; Bmal1; Cancer invasion; Circadian clocks; Tumor suppressor

Indexed keywords

GELATINASE A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL W; PROTEIN KINASE B;

ARTICLE; BCL W GENE; BIOACCUMULATION; CANCER CELL; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLIOMA CELL; HUMAN; HUMAN CELL; LUNG CANCER; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS REGULATORY PROTEINS; ARNTL TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL MOVEMENT; GENE KNOCKDOWN TECHNIQUES; GENES, TUMOR SUPPRESSOR; HUMANS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84876254318     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2381     Document Type: Article

References (34)

1. Friedl P and Alexander S: Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147: 992-1009, 2011.
2. Mohawk JA, Green CB and Takahashi JS: Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 35: 445-462, 2012.
3. Takahashi JS, Hong HK, Ko CH and McDearmon EL: The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 9: 764-775, 2008.
4. Rafnsson V, Tulinius H, Jónasson JG and Hrafnkelsson J: Risk of breast cancer in female flight attendants: a population-based study (Iceland). Cancer Causes Control 12: 95-101, 2001.
5. Viswanathan AN, Hankinson SE and Schernhammer ES: Night shift work and the risk of endometrial cancer. Cancer Res 67: 10618-10622, 2007.
6. Schernhammer ES, Kroenke CH, Laden F and Hankinson SE: Night work and risk of breast cancer. Epidemiology 17: 108-111, 2006.
7. Fu L and Lee CC: The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer 3: 350-361, 2003.
8. Dunlap JC: Molecular bases for circadian clocks. Cell 96: 271-290, 1999.
9. Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U and Schibler U: The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110: 251-260, 2002
10. Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA and Hogenesch JB: A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43: 527-537, 2004.
11. Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK and Koeffler HP: Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia. Blood 106: 2827-2836, 2005.
12. Winter SL, Bosnoyan-Collins L, Pinnaduwage D and Andrulis IL: Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors. Neoplasia 9: 797-800, 2007.
13. Yeh KT, Yang MY, Liu TC, Chen JC, Chan WL, Lin SF and Chang JG: Abnormal expression of period 1 (PER1) in endometrial carcinoma. J Pathol 206: 111-120, 2005.
14. Pogue-Geile KL, Lyons-Weiler J and Whitcomb DC: Molecular overlap of fly circadian rhythms and human pancreatic cancer. Cancer Lett 243: 55-57, 2006.
15. Fu L, Pelicano H, Liu J, Huang P and Lee C: The circadian gene period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41-50, 2002.
16. Gery S, Komatsu N, Baldjyan L, Yu A, Koo D and Koeffler HP: The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 22: 375-382, 2006.
17. Hua H, Wang Y, Wan C, Liu Y, Zhu B, Wang X, Wang Z and Ding JM: Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Cancer Gene Ther 14: 815-818, 2007.
18. Oda A, Katayose Y, Yabuuchi S, Yamamoto K, Mizuma M, Shirasou S, Onogawa T, Ohtsuka H, Yoshida H, Hayashi H, Rikiyama T, Kim H, Choe Y, Kim K, Son H, Motoi F, Egawa S and Unno M: Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin. Anticancer Res 29: 1201-1209, 2009.
19. King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW and Takahashi JS: Positional cloning of the mouse circadian clock gene. Cell 89: 641-653, 1997.
20. Zeng ZL, Wu MW, Sun J, Sun YL, Cai YC, Huang YJ and Xian LJ: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem 148: 319-326, 2010.
21. Kim EM, Kim J, Park JK, Hwang SG, Kim WJ, Lee WJ, Kang SW and Um HD: Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. Cell Signal 24: 1163-1172, 2012.
22. Lehman TA, Bennett WP, Metcalf RA, Welsh JA, Ecker J, Modali RV, Ullrich S, Romano JW, Appella E, Testa JR, Gerwin BI and Harris CC: p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res 51: 4090-4096, 1991.
23. Soussi T, Dehouche K and Béroud C: p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. Hum Mutat 15: 105-113, 2000.
24. Roberson RS, Kussick SJ, Vallieres E, Chen SY and Wu DY: Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res 65: 2795-2803, 2005.
25. Shukla S, Maclennan GT, Hartman DJ, Fu P, Resnick MI and Gupta S: Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int J Cancer 121: 1424-1432, 2007.
26. Bae IH, Park MJ, Yoon SH, Kang SW, Lee SS, Choi KM and Um HD: Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. Cancer Res 66: 4991-4995, 2006.
27. Bae IH, Yoon SH, Lee SB, Park JK, Ho JN and Um HD: Signaling components involved in Bcl-w-induced migration of gastric cancer cells. Cancer Lett 277: 22-28, 2008.
28. Kong D and Yamori T: Advances in development of phosphatidylinositol 3-kinase inhibitors. Curr Med Chem 16: 2839-2854, 2009.
29. Cory S and Adams JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656, 2002.
30. Lee HW, Lee SS, Lee SJ and Um HD: Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation. Cancer Res 63: 1093-1100, 2003.
31. Hoelzinger DB, Mariani L, Weis J, Woyke T, Berens TJ, McDonough WS, Sloan A, Coons SW and Berens ME: Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 7: 7-16, 2005.
32. Chen-Goodspeed M and Lee CC: Tumor suppression and circadian function. J Biol Rhythms 22: 291-298, 2007.
33. Mazzoccoli G, Panza A, Valvano MR, Palumbo O, Carella M, Pazienza V, Biscaglia G, Tavano F, Di Sebastiano P, Andriulli A and Piepoli A: Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int 28: 841-851, 2011.
34. Muller PA, Vousden KH and Norman JC: p53 and its mutants in tumor cell migration and invasion. J Cell Biol 192: 209-218, 2011.