Methylation of wnt7a is modulated by dnmt1 and cigarette smoke condensate in non-small cell lung cancer

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Tennis, Meredith A ^a   VanScoyk, Michelle M ^a   Wilson, Lora A ^a   Kelley, Nicole ^a   Winn, Robert A ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CIGARETTE SMOKE CONDENSATE; DNA METHYLTRANSFERASE 1; SHORT HAIRPIN RNA; WNT7A PROTEIN; AZACITIDINE; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DRUG DERIVATIVE; WNT PROTEIN; WNT7A PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; PHENOTYPE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN METHYLATION; SIGNAL TRANSDUCTION; DNA METHYLATION; DRUG EFFECT; EPITHELIUM CELL; GENETICS; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; SMOKE; SMOKING;

AZACITIDINE; CARCINOMA, NON-SMALL-CELL LUNG; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPITHELIAL CELLS; LUNG; LUNG NEOPLASMS; PHENOTYPE; PROMOTER REGIONS, GENETIC; SMOKE; SMOKING; WNT PROTEINS;

EID: 84857758880     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032921     Document Type: Article

References (29)

1. Kirikoshi H, Katoh M, (2002) Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Int J Oncol 21: 895-900.
2. Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, et al. (2005) Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. J Biol Chem 280: 19625-19634.
3. Calvo R, West J, Franklin W, Erickson P, Bemis L, et al. (2000) Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 97: 12776-12781.
4. Chen C, Yin N, Yin B, Lu Q, DNA methylation in thoracic neoplasms. Cancer Lett 301: 7-16.
5. Kersting M, Friedl C, Kraus A, Behn M, Pankow W, et al. (2000) Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol 18: 3221-3229.
6. Maruyama R, Sugio K, Yoshino I, Maehara Y, Gazdar AF, (2004) Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma. Cancer 100: 1472-1477.
7. Dammann R, Takahashi T, Pfeifer GP, (2001) The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 20: 3563-3567.
8. Groeger AM, Caputi M, Esposito V, De Luca A, Bagella L, et al. (1999) Independent prognostic role of p16 expression in lung cancer. J Thorac Cardiovasc Surg 118: 529-535.
9. Yanagawa N, Tamura G, Oizumi H, Takahashi N, Shimazaki Y, et al. (2002) Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers. Jpn J Cancer Res 93: 1107-1113.
10. Tomizawa Y, Iijima H, Nomoto T, Iwasaki Y, Otani Y, et al. (2004) Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. Lung Cancer 46: 305-312.
11. Liu F, Killian JK, Yang M, Walker RL, Hong JA, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 29: 3650-3664.
12. Tang M, Xu W, Wang Q, Xiao W, Xu R, (2009) Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics 10: 336-352.
13. Li J, Ying J, Fan Y, Wu L, Ying Y, et al. WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol Ther 10: 617-624.
14. Ahn JB, Chung WB, Maeda O, Shin SJ, Kim HS, et al. DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer 117: 1847-1854.
15. Shu J, Jelinek J, Chang H, Shen L, Qin T, et al. (2006) Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Cancer Res 66: 5077-5084.
16. Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, et al. (2003) Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 63: 3735-3742.
17. Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, et al. (1992) Three distinct regions involved in 3p deletion in human lung cancer. Oncogene 7: 445-449.
18. Lin RK, Hsieh YS, Lin P, Hsu HS, Chen CY, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest 120: 521-532.
19. Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT Jr, et al. (2006) Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. J Biol Chem 281: 26943-26950.
20. Mathers JC, Strathdee G, Relton CL, Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet 71: 3-39.
21. Xi S, Yang M, Tao Y, Xu H, Shan J, et al. (2010) Cigarette smoke induces C/EBP-beta-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells. PLoS ONE 5: e13764.
22. Huang Y, Liu G, Zhang B, Xu G, Xiong W, et al. (2010) Wnt-5a regulates proliferation in lung cancer cells. Oncol Rep 23: 177-181.
23. Soltermann A, Tischler V, Arbogast S, Braun J, Probst-Hensch N, et al. (2008) Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer. Clin Cancer Res 14: 7430-7437.
24. Kim H, Kwon YM, Kim JS, Han J, Shim YM, et al. (2006) Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer. Cancer 107: 1042-1049.
25. Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, et al. (2008) Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res 68: 9005-9014.
26. Liu WB, Cui ZH, Ao L, Zhou ZY, Zhou YH, et al. (2011) Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Toxicol Appl Pharmacol 251: 70-78.
27. Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, et al. (2010) Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia 12: 244-253.
28. Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, et al. (2004) Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 64: 9027-9034.
29. Debnath J, Muthuswamy SK, Brugge JS, (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30: 256-268.