Serotonergic and adrenergic drug interactions associated with linezolid: A critical review andpractical management approach;Interacciones de medicamentos con linezolid que resultan en reacciones serotonérgicas y adrenérgicas: Una revisión crítica y acercamiento práctico de su manejo

Annals of Pharmacotherapy

Volumn 47, Issue 4, 2013, Pages 543-560

  Ramsey, Tasha D ^a   Lau, Tim T Y ^a   Ensom, Mary H H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; BUSPIRONE; CITALOPRAM; CLONAZEPAM; DEXTROMETHORPHAN; DIGOXIN; DOCUSATE SODIUM; DULOXETINE; ESCITALOPRAM; FLUOXETINE; FUROSEMIDE; HYDROMORPHONE; INSULIN; LINEZOLID; METFORMIN; METHOTREXATE; OXAZEPAM; PAROXETINE; PERINDOPRIL; PETHIDINE; PHENYLPROPANOLAMINE; PLACEBO; PREDNISONE; PSEUDOEPHEDRINE; SEROTONIN AGONIST; SERTRALINE; TORASEMIDE; TRAZODONE; VENLAFAXINE;

ABDOMINAL INFECTION; ABSCESS; AGITATION; ANXIETY DISORDER; AREA UNDER THE CURVE; ARTICLE; CELLULITIS; CLINICAL PRACTICE; CLINICAL TRIAL (TOPIC); CONFUSION; DATA EXTRACTION; DIARRHEA; DRUG WITHDRAWAL; DYSARTHRIA; EMBASE; FLUSHING; HEART ARREST; HEART VENTRICLE FUNCTION; HOT FLUSH; HUMAN; HYPERTENSION; HYPERTHERMIA; HYPOTENSION; INCIDENCE; LEUKOPENIA; LIVER FAILURE; MAXIMUM PLASMA CONCENTRATION; MEDLINE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MYOCLONUS; NAUSEA AND VOMITING; NEUTROPENIA; OSTEOMYELITIS; PANIC; PANNICULITIS; PARESTHESIA; PHASE 3 CLINICAL TRIAL (TOPIC); PHASE 4 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; RIGIDITY; SEROTONIN SYNDROME; SIDE EFFECT; SLEEP DISORDER; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; THROMBOCYTOPENIA; TREMOR; URINARY TRACT INFECTION;

EID: 84876233517     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R604     Document Type: Article

References (46)

1. Product monograph. Zyvoxam (linezolid). Kirkland, Quebec: Pfizer Canada Inc., Oct 5, 2009. www.pfizer.ca/en/our_products/products/monograph/143 (accessed 2012 Sept 18).
2. MacDougall C, Chambers HF. Protein synthesis inhibitors and miscellaneous antibacterial agents. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman's the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill, 2011. www.accessmedicine.com/content. aspx?aID=16677888 (accessed 2012 Sept 18).
3. Stalker DJ, Jungbluth GL. Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial. Clin Pharmacokinet 2003;42:1129-40.
4. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med 2005; 352:1112-20.
5. Gillman PK. A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biol Psychiatry 2006;59: 1046-51.
6. Flomenbaum NE, Goldfrank LR, Hoffman RS, Howland MA, Lewin NA, Nelson LS. Initial evaluation of the patient: vital signs and toxic syndromes. In: Goldfrank's toxicologic emergencies. 8th ed. New York: McGraw-Hill Medical, 2006:231-2.
7. Sternbach H. The serotonin syndrome. Am J Psychiatry 1991;148:705-13.
8. Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM 2003;96:635-42.
9. Baxter K, ed. Stockley's drug interactions [online]. London: Pharmaceutical Press, 2012. www.medicinescomplete.com.ezproxy.library.ubc.ca/ (accessed 2012 Sept 18).
10. Horn JR, Hansten PD, Chan L-N. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother 2007;41:674-80. doi: 10.1345/aph.1H423
11. Hines LE, Malone DC, Murphy JE. Recommendations for generating, evaluating, and implementing drug-drug interaction evidence. Pharmacotherapy 2012;32:304-13.
12. Hendershot PE, Antal EJ, Welshman IR, Batts DH, Hopkins NK. Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr. J Clin Pharmacol 2001;41:563-72.
13. Butterfield JM, Lawrence KR, Reisman A, Huang DB, Thompson CA, Lodise TP. Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of Phase III and IV randomized clinical trial data. J Antimicrob Chemother 2012;67:494-502.
14. Bishop E, Melvani S, Howden BP, Charles PG, Grayson ML. Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients. Antimicrob Agents Chemother 2006;50:1599-602.
15. Taylor JJ, Estes LL, Wilson JW. Linezolid and serotonergic drug interactions (letter). Clin Infect Dis 2006;43:1371.
16. Lorenz RA, Vandenberg AM, Canepa EA. Serotonergic antidepressants and linezolid: a retrospective chart review and presentation of cases. Int J Psychiatry Med 2008;38:81-90.
17. Go AC, Golightly LK, Barber GR, Barron MA. Linezolid interaction with serotonin reuptake inhibitors: report of two cases and incidence assessment. Drug Metabol Drug Interact 2010;25:41-7.
18. Lawrence KR, Adra M, Gillman PK. Serotonin toxicity associated with the use of linezolid: a review of postmarketing data. Clin Infect Dis 2006;42:1578-83.
19. Morrison EK, Rowe AS. Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia. J Clin Pharm Ther 2012;37:610-3.
20. Bernard L, Stern R, Lew D, Hoffmeyer P. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clin Infect Dis 2003;36:1197.
21. Hachem RY, Hicks K, Huen A, Raad I. Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin Infect Dis 2003;37:e8-11.
22. Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram. J Am Med Dir Assoc 2004;5:111-3.
23. Bergeron L, Boulé M, Perreault S. Serotonin toxicity associated with concomitant use of linezolid. Ann Pharmacother 2005;39:956-61. doi: 10.1345/aph.1E523
24. DeBellis RJ, Schaefer OP, Liquori M, Volturo GA. Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient. J Intensive Care Med 2005;20:351-3.
25. McClean M, Walsh JC, Condon F. Serotonin syndrome in an orthopaedic patient secondary to linezolid therapy for MRSA infection. Ir J Med Sci 2011;180:285-6.
26. Strouse TB, Kerrihard TN, Forscher CA, Zakowski P. Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine. J Clin Psychopharmacol 2006;26:681-3.
27. Thomas CR, Rosenberg M, Blythe V, Meyer WJ III. Serotonin syndrome and linezolid (letter). J Am Acad Child Adolesc Psychiatry 2004;43:790.
28. Morales N, Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics 2005;46: 274-5.
29. Steinberg M, Morin AK. Mild serotonin syndrome associated with concurrent linezolid and fluoxetine. Am J Health Syst Pharm 2007;64:59-62.
30. Das PK, Warkentin DI, Hewko R, Forrest DL. Serotonin syndrome after concomitant treatment with linezolid and meperidine. Clin Infect Dis 2008;46:264-5.
31. Aga VM, Barlage NE, Jefferson JW. Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants. J Clin Psychiatry 2003;64:609-11.
32. Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clin Infect Dis 2002;34:1651-2.
33. Lavery S, Ravi H, McDaniel WW, Pushkin YR. Linezolid and serotonin syndrome. Psychosomatics 2001;42:432-4.
34. Clark DB, Andrus MR, Byrd DC. Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature. Pharmacotherapy 2006;26:269-76.
35. Sahiner V, Erden Aki SO. Serotonin syndrome associated with linezolid use: a case report. Turk Psikiyatri Derg 2009;20:398-402.
36. Jones SL, Athan E, O'Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. J Antimicrob Chemother 2004;54: 289-90.
37. Packer S, Berman SA. Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid. Am J Psychiatry 2007;164:346-7.
38. Mason LW, Randhawa KS, Carpenter EC. Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty. Orthopedics 2008;31:1140.
39. Miller DG, Lovell EO. Antibiotic-induced serotonin syndrome. J Emerg Med 2011;40:25-7.
40. Marcucci C, Sandson NB, Dunlap JA. Linezolid-bupropion interaction as possible etiology of severe intermittent intraoperative hypertension? Anesthesiology 2004;101:1487-8.
41. Serio RN. Acute delirium associated with combined diphenhydramine and linezolid use. Ann Pharmacother 2004;38:62-5. doi: 10.1345/aph.1D018
42. Ferry T, Ponceau B, Simon M, et al. Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases. Infection 2005;33:151-4.
43. Dardis C, Omoregie E, Ly V. Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using a selective serotonin reuptake inhibitor. Neurologist 2012;18:204-5.
44. Beekmann SE, Gilbert DN, Polgreen PM, IDSA Emerging Infections Network. Toxicity of extended courses of linezolid: results of an Infectious Diseases Society of America Emerging Infections Network survey. Diagn Microbiol Infect Dis 2008;62:407-10.
45. Ables AZ, Nagubilli R. Prevention, recognition, and management of serotonin syndrome. Am Fam Physician 2010;81:1139-42.
46. Flomenbaum NE, Goldfrank LR, Hoffman RS, Howland MA, Lewin NA, Nelson LS. Principles of managing the poisoned or overdosed patient. In: Goldfrank's toxicologic emergencies. 8th ed. New York: McGraw-Hill Medical, 2006:231-2.