Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: An analysis of Phase III and IV randomized clinical trial data

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 2, 2012, Pages 494-502

  Butterfield, Jill M ^a   Lawrence, Kenneth R ^b,d   Reisman, Arlene ^c   Huang, David B ^c,e   Thompson, Charles A ^c   Lodise, Thomas P ^a  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c PFIZER INC   (United States)

^d ASTRAZENECA   (United Kingdom)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Drug interactions; Oxazolidinones; Serotonergic; Syndrome

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CEFADROXIL; CEFPODOXIME; CEFTRIAXONE; CLARITHROMYCIN; DICLOXACILLIN; FLUCLOXACILLIN; LINEZOLID; OXACILLIN; SEROTONIN; SEROTONIN AGONIST; SULTAMICILLIN; TEICOPLANIN; VANCOMYCIN;

AGITATION; ARTICLE; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL (TOPIC); COORDINATION DISORDER; DEMOGRAPHY; DIAPHORESIS; DIARRHEA; DRUG FEVER; DRUG USE; HUMAN; HYPERREFLEXIA; META ANALYSIS; MYOCLONUS; PHASE 3 CLINICAL TRIAL (TOPIC); PHASE 4 CLINICAL TRIAL (TOPIC); SEROTONIN TOXICITY; SHIVERING; SIDE EFFECT; TOXICITY; TREMOR;

ACETAMIDES; ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS, PHASE III AS TOPIC; CLINICAL TRIALS, PHASE IV AS TOPIC; DATABASES, FACTUAL; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; MIDDLE AGED; OXAZOLIDINONES; SEROTONIN; SEROTONIN AGENTS;

EID: 84855846603     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr467     Document Type: Article

References (20)

1. Sternbach H. The serotonin syndrome. Am J Psychiatry 1991; 148: 705-13.
2. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med 2005; 352: 1112-20.
3. Gillman PK. Serotonin syndrome: history and risk. Fundam Clin Pharmacol 1998; 12: 482-91.
4. Isbister GK, Buckley NA. The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuropharmacol 2005; 28: 205-14.
5. Zyvox Package Insert. New York, NY: Pfizer Inc., 2010.
6. Yamada M, Yasuhara H. Clinical pharmacology of MAO inhibitors: safety and future. Neurotoxicology 2004; 25: 215-21.
7. Lawrence KR, Adra M, Gillman PK. Serotonin toxicity associated with the use of linezolid: a review of postmarketing data. Clin Infect Dis 2006; 42: 1578-83.
8. Sola CL, Bostwick JM, Hart DA et al. Anticipating potential linezolid-SSRI interactions in the general hospital setting: an MAOI in disguise. Mayo Clin Proc 2006; 81: 330-4.
9. Aga VM, Barklage NE, Jefferson JW. Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants. J Clin Psychiatry 2003; 64: 609-11.
10. Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clin Infect Dis 2002; 34: 1651-2.
11. Lavery S, Ravi H, McDaniel WW et al. Linezolid and serotonin syndrome. Psychosomatics 2001; 42: 432-4.
12. Bernard L, Stern R, Lew D et al. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clin Infect Dis 2003; 36: 1197.
13. Hachem RY, Hicks K, Huen A et al. Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin Infect Dis 2003; 37: e8-11.
14. Jones SL, Athan E, O'Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. J Antimicrob Chemother 2004; 54: 289-90.
15. Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram. J Am Med Dir Assoc 2004; 5: 111-3.
16. Thomas CR, Rosenberg M, Blythe V et al. Serotonin syndrome and linezolid. J Am Acad Child Adolesc Psychiatry 2004; 43: 790.
17. Morales N, Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics 2005; 46: 274-5.
18. Bergeron L, Boule M, Perreault S. Serotonin toxicity associated with concomitant use of linezolid. Ann Pharmacother 2005; 39: 956-61.
19. Taylor JJ, Wilson JW, Estes LL. Linezolid and serotonergic drug interactions: a retrospective survey. Clin Infect Dis 2006; 43: 180-7.
20. Dunkley EJ, Isbister GK, Sibbritt D et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM 2003; 96: 635-42.