Serotonergic antidepressants and linezolid: A retrospective chart review and presentation of cases

International Journal of Psychiatry in Medicine

Volumn 38, Issue 1, 2008, Pages 81-90

  Lorenz, Raymond A ^a,d   Vandenberg, Amy M ^b   Canepa, Elizabeth A ^c  

^a AUBURN UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d Mobile Mental Health Center   (United States)

Author keywords

Antidepressants; Linezolid; Serotonin syndrome

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BUSPIRONE; CEFEPIME; CIPROFLOXACIN; CITALOPRAM; CYCLOBENZAPRINE; DULOXETINE; ESCITALOPRAM; FENTANYL; FLUOXETINE; FLUVOXAMINE; LINEZOLID; LITHIUM; LORAZEPAM; METHADONE; METOCLOPRAMIDE; MIRTAZAPINE; ONDANSETRON; PAROXETINE; PETHIDINE; QUETIAPINE; SERTRALINE; SUMATRIPTAN; TRAMADOL; TRAZODONE; UNINDEXED DRUG; VALPROIC ACID; VANCOMYCIN; VENLAFAXINE; ANTIINFECTIVE AGENT; SEROTONIN RECEPTOR AFFECTING AGENT; SEROTONIN UPTAKE INHIBITOR;

ABDOMINAL INFECTION; ADD ON THERAPY; ADOLESCENT; ADULT; AGED; AGITATION; ARTICLE; CHILD; CLINICAL ARTICLE; CLONUS; COORDINATION DISORDER; DEPRESSION; DIAPHORESIS; DIARRHEA; DRUG DOSE ESCALATION; DRUG WITHDRAWAL; EYE DISEASE; FEMALE; FEVER; FLUSHING; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HYPERREFLEXIA; INTENSIVE CARE UNIT; KIDNEY FAILURE; LEUKOCYTE COUNT; LUNG EMBOLISM; MALE; MEDICAL RECORD REVIEW; MENTAL HEALTH; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MIXED INFECTION; MUSCLE RIGIDITY; MYOCLONUS; NEUROLEPTIC MALIGNANT SYNDROME; PRESCHOOL CHILD; PROBABILITY SAMPLE; PYELONEPHRITIS; RETROSPECTIVE STUDY; SEROTONIN SYNDROME; SHIVERING; SIDE EFFECT; TEMPERATURE; TONIC CLONIC SEIZURE; TREATMENT DURATION; TREMOR; UROSEPSIS; CASE REPORT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG INTERACTION; GRAND MAL EPILEPSY; MEDICAL RECORD; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CHILD, PRESCHOOL; CITALOPRAM; DEPRESSIVE DISORDER; DRUG INTERACTIONS; EPILEPSY, TONIC-CLONIC; FEMALE; HUMANS; MALE; MEDICAL RECORDS; MIDDLE AGED; MYOCLONUS; RETROSPECTIVE STUDIES; SEROTONIN AGENTS; SEROTONIN SYNDROME; SEROTONIN UPTAKE INHIBITORS;

EID: 50649105318     PISSN: 00912174     EISSN: 15413527     Source Type: Journal    
DOI: 10.2190/PM.38.1.h     Document Type: Article

References (21)

1. Bergeron L, Boulé M, Perreault S. Serotonin toxicity associated with concomitant use of linezolid. Annals of Pharmacotherapy 2005;39:956-961. DOI 10.1345/aph.1E523
2. Hachem RY, Hicks K, Huen A, Raad I. Myelosupression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clinical Infectious Diseases 2003;37:e8-11. Epub 25 June 2003
3. Bernard L, Stern R, Lew D, Hoffmeyer P. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clinical Infectious Diseases 2003;63:1197. Epub 21 Apr 2003
4. Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: An interaction between linezolid and citalopram. Journal of the American Medical Directors Association 2004;5:111-113. DOI 110.1097/01JAM.0000110645.20530.46
5. DeBellis RJ, Schaefer OP, Liquori M, Volturo GA. Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient. Journal of Intensive Care Medicine 2005;20:351-353. DOI 10.1177/088506660528085
6. Strouse TB, Kerrihard TN, Forscher CA, Zakowski P. Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine. Journal of Clinical Psychopharmacology 2006;26:681-683
7. Thomas CR, Rosenberg M, Blythe V, Meyer WJ. Serotonin syndrome and linezolid. Journal of the American Academy of Adolescent Psychiatry 2004;43:790. DOI 10.1097/01.chi.0000128830.13997.aa
8. Steinberg M, Morin AK. Mild serotonin syndrome associated with concurrent linezolid and fluoxetine. American Journal of Health-System Pharmacy 2007;64:59-62. DOI 10.2146/ajhp060227
9. Morales N, Vermette H. Serotonin syndrome associated with linezolid after discontinuation of fluoxetine. Psychosomatics 2005;46:274-275
10. Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clinical Infectious Diseases 2002;34:1651-1652. Epub 23 May 2002
11. Morales-Molina JA, Mateu-de Antonio J, Grau Cerrato S, Marin-Casino M. [Likely serotonergic syndrome from an interaction between amitriptyline, paroxetine, and linezolid]. Farm Hospital 2005;29:292-299
12. Taylor JJ, Wilson JW, Estes L. Linezolid and serotonergic drug interactions: a retrospective survey. Clinical Infectious Diseases 2006;43:180-187. Epub 9 Jun 2006
13. Lavery S, Ravi H, McDaniel WW, Pushkin YR. Linezolid and serotonin syndrome. Psychosomatics 2001;42:432-434
14. Clark DB, Andrus MR, Byrd DC. Drug interactions between linezolid and selective serotonin reuptake inhibitors: Case report involving sertraline and review of the literature. Pharmacotherapy 2006;26:269-276
15. Packer S, Berman SA. Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid. American Journal of Psychiatry 2007;164:346-347
16. Jones SL, Athan E, O'Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. Journal of Antimicrobial Chemotherapy 2004;54:289-290. Epub 12 May 2004. DOI 10.1093/jac/dkh257
17. Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: Simple and accurate diagnostic decision rules for serotonin toxicity. Quarterly Journal of Medicine 2003;96:635-642.
18. Boyer EW, Shannon M. The serotonin syndrome. New England Journal of Medicine 2005;352:1112-20.
19. Taylor JJ, Wilson JW, Estes LL. Linezolid and serotonergic drug interactions: A retrospective survey. Clinical Infectious Diseases 2006 Jul 15;43(2):180-187.
20. Sternbach H. The serotonin syndrome. American Journal of Psychiatry 1991;148:705-713.
21. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clinical Pharmacology and Therapeutics 1981;30:239-245