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Becker HI, Walton RC, Diamant JI, Zegans ME. Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate. Arch Ophthalmol 2004; 122:1063-1066.
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Stewart WC, Stewart JA, Jenkins JN, Jackson AL. Corneal punctate staining with latanoprost, bimatoprost, and travoprost in healthy subjects. J Glaucoma 2003; 12:475-479.
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A comparison of the fourth-generation fluoroquinolones gatifloxacin 0.3% and moxifloxacin 0.5% in terms of ocular tolerability
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Donnenfeld E, Perry HD, Chruscicki DA, et al. A comparison of the fourth-generation fluoroquinolones gatifloxacin 0.3% and moxifloxacin 0.5% in terms of ocular tolerability. Curr Med Res Opin 2004; 20:1753-1758. This study found that despite the absence of preservative, a new-generation fluoroquinolone may be less tolerated, by indirect mechanisms involving prostaglandin release.
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Mullins RJ, Lones R, Dutta B. Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops. Australas J Dermatol 2004; 45:151-152.
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Herbst RA, Uter W, Pirker C, et al. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermatitis 2004; 51: 13-19. The authors tested a large series of patients with drug-induced periocular dermatitis. In addition to standard allergens, eyedrops should be tested to determine the accurate compounds responsible for atypical blepharitis.
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Herbst, R.A.1
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Flach AJ. Does medical treatment influence the success of trabeculectomy? Trans Am Ophthalmol Soc 2004; 102:219-223. A meta-analysis aimed at determining from the literature the influence of topical treatments on filtration surgery. Most studies consistently described inflammatory infiltrates in the conjunctiva that could favour further fibrosis. However, no definitive conclusions can be drawn from those studies.
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Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride
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Nenciu A, Stefan C, Ardelean C. Structural and immunohistochemical changes of conjunctiva induced by topical glaucoma medication [in Romanian]. Oftalmologia 2004; 48:35-42. A new consistent study confirming that antiglaucoma eyedrops cause inflammatory infiltrates in the conjunctiva.
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Manni G, Centofanti M, Oddone F, et al. Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers. Am J Ophthalmol 2005; 139:72-77. A cross-over study bringing major information: first a proinflammatory cytokine is stimulated in the tears of patients with antiglaucoma medications; second, this increased cytokine secretion was only found with preserved timolol, which further demonstrates the role of preservative in inducing conjunctival inflammation.
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Am J Ophthalmol
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