Anti-diabetic effect of ramulus mori polysaccharides, isolated from Morus alba L., on STZ-diabetic mice through blocking inflammatory response and attenuating oxidative stress

International Immunopharmacology

Volumn 16, Issue 1, 2013, Pages 93-99

  Guo, Chao ^a   Li, Rong ^c   Zheng, Ni ^a   Xu, Lingyuan ^b   Liang, Tao ^a   He, Qiaoling ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b Youjiang Medical University for Nationalities   (China)

^c GUILIN MEDICAL UNIVERSITY   (China)

Author keywords

Glycemia; Inflammation; Oxidative stress; Ramulus mori polysaccharides

Indexed keywords

ANTIDIABETIC AGENT; CYCLOOXYGENASE 2; GLUCOSE; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; INSULIN; INTERLEUKIN 6; INTERLEUKIN 8; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; METFORMIN; MULBERRY EXTRACT; RAMULUS MORI POLYSACCHARIDE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; ATTENUATION; BODY WEIGHT; DRUG EFFECT; DRUG SAFETY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HISTOPATHOLOGY; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; THERAPY EFFECT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CYCLOOXYGENASE 2; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; GLUTATHIONE REDUCTASE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MALONDIALDEHYDE; MICE; MORUS; OXIDATIVE STRESS; PANCREAS; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; SUPEROXIDE DISMUTASE;

EID: 84876191884     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.03.029     Document Type: Article

References (42)

1. P. Zimmet, E.J. Boyko, G.R. Collier, and M. de Courten Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players Ann N Y Acad Sci 892 1999 25 44
2. N.L. Rasgon, H.A. Kenna, M.F. Reynolds-May, P.G. Stemmle, M. Vemuri, and W. Marsh Metabolic dysfunction in women with bipolar disorder: the potential influence of family history of type 2 diabetes mellitus Bipolar Disord 12 2010 504 513
3. K. Cusi Lessons learned from studying families genetically predisposed to type 2 diabetes mellitus Curr Diab Rep 9 2009 200 207
4. C.S. Mathew, M. Dominic, R. Isaac, and J.J. Jacob Prevalence of depression in consecutive patients with type 2 diabetes mellitus of 5-year duration and its impact on glycemic control Indian J Endocrinol Metab 16 2012 764 768
5. A.E. Kitabchi, and E.A. Nyenwe Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state Endocrinol Metab Clin North Am 35 2006 725 751
6. A.E. Kitabchi, G.E. Umpierrez, J.N. Fisher, M.B. Murphy, and F.B. Stentz Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state J Clin Endocrinol Metab 93 2008 1541 1552
7. E.A. Nyenwe, and A.E. Kitabchi Evidence-based management of hyperglycemic emergencies in diabetes mellitus Diabetes Res Clin Pract 94 2011 340 351
8. M.R. Kraine, and R.M. Tisch The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue Environ Health Perspect 5 1999 777 781
9. T.L. Hectors, C. Vanparys, K. van der Ven, G.A. Martens, P.G. Jorens, and L.F. Van Gaal Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function Diabetologia 54 2011 1273 1290
10. W.L. Li, H.C. Zheng, J. Bukuru, and N. De Kimpe Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus J Ethnopharmacol 92 2004 1 21
11. Y. Gu, Y. Zhang, X. Shi, X. Li, J. Hong, and J. Chen Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics Talanta 81 2010 766 772
12. F. Ye, Z. Shen, and M. Xie Alpha-glucosidase inhibition from a Chinese medical herb (ramulus mori) in normal and diabetic rats and mice Phytomedicine 9 2002 161 166
13. F. Ye, Z.F. Shen, F.X. Qiao, D.Y. Zhao, and M.Z. Xie Experimental treatment of complications in alloxan diabetic rats with alpha-glucosidase inhibitor from the Chinese medicinal herb ramulus mori Yao Xue Xue Bao 37 2002 108 112
14. Z. Zhang, and L. Shi Anti-inflammatory and analgesic properties of cis-mulberroside A from ramulus mori Fitoterapia 81 2010 214 218
15. Z. Zhang, and L. Shi Detection of antioxidant active compounds in mori ramulus by HPLC-MS-DPPH Zhongguo Zhong Yao Za Zhi 37 2012 800 802
16. K. Srinivasan, and P. Ramarao Animal models in type 2 diabetes research: an overview Indian J Med Res 125 2007 451 472
17. A.E. Kitabchi, G.E. Umpierrez, M.B. Murphy, E.J. Barrett, R.A. Kreisberg, and J.I. Malone Management of hyperglycemic crises in patients with diabetes Diabetes Care 24 2001 131 153
18. D.M. Nathan, J.B. Buse, M.B. Davidson, R.J. Heine, R.R. Holman, and R. Sherwin Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes Diabetes Care 29 2006 1963 1972
19. D.M. Nathan, J.B. Buse, M.B. Davidson, E. Ferrannini, R.R. Holman, and R. Sherwin Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes Diabetes Care 32 2009 193 203
20. T. Shimizu, D.M. Nathan, J.B. Buse, M.B. Davidson, E. Ferrannini, and R.R. Holman Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes Nihon rinsho Jpn J Clin Med 3 2012 591 601
21. J.H. Kang, T. Goto, I.S. Han, T. Kawada, Y.M. Kim, and R. Yu Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet Obesity (Silver Spring) 18 2010 780 787
22. S. El Akoum, V. Lamontagne, I. Cloutier, and J.F. Tanguay Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice Diabetol Metab Syndr 3 2011 34 45
23. T. Szkudelski The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Physiol Res 50 2001 537 546
24. S. Lenzen The mechanisms of alloxan- and streptozotocin-induced diabetes Diabetologia 51 2008 216 226
25. E. Tomás, Y.S. Lin, Z. Dagher, A. Saha, Z. Luo, and Y. Ido Hyperglycemia and insulin resistance: possible mechanisms Ann N Y Acad Sci 967 2002 43 51
26. K.G. Alberti, and P.Z. Zimmet Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 1998 539 553
27. G. Rossi American Diabetes Association. Diagnosis and classification of diabetes mellitus Recenti Prog Med 101 2010 274 276
28. P. Pánczél Diagnosis of diabetes mellitus Orv Hetil 147 2006 1223 1238
29. G.L. ing The role of inflammatory cytokines in diabetes and its complications J Periodontol 79 2008 1527 1534
30. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat Rev Immunol 11 2011 98 107
31. M.Y. Donath, D.M. Schumann, M. Faulenbach, H. Ellingsgaard, A. Perren, and J.A. Ehses Islet inflammation in type 2 diabetes: from metabolic stress to therapy Diabetes Care 2 2008 161 164
32. B. Brooks-Worrell, and J.P. Palmer Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation Clin Exp Immunol 167 2012 40 46
33. M.R. Heitmeier, C.B. Kelly, N.J. Ensor, K.A. Gibson, K.G. Mullis, and J.A. Corbett Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets J Biol Chem 279 2004 53145 53151
34. S.J. Persaud, C.J. Burns, V.D. Belin, and P.M. Jones Glucose-induced regulation of COX-2 expression in human islets of Langerhans Diabetes 1 2004 190 192
35. P. Pérez-Matute, M.A. Zulet, and J.A. Martínez Reactive species and diabetes: counteracting oxidative stress to improve health Curr Opin Pharmacol 9 2009 771 779
36. P.D. Ray, B.W. Huang, and Y. Tsuji Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Cell Signal 24 2012 981 990
37. A. Djordjevic, S. Spasic, A. Jovanovic-Galovic, R. Djordjevic, and G. Grubor-Lajsic Oxidative stress in diabetic pregnancy: SOD, CAT and GSH-Px activity and lipid peroxidation products J Matern Fetal Neonatal Med 16 2004 367 372
38. H. Esterbauer Cytotoxicity and genotoxicity of lipid-oxidation products Am J Clin Nutr 57 1993 779 785
39. A.E. Kartikasari, F.A. Wagener, A. Yachie, E.T. Wiegerinck, E.H. Kemna, and D.W. Swinkels Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency J Cell Mol Med 13 2009 3091 3102
40. S. Immenschuh, E. Baumgart-Vogt, and S. Mueller Heme oxygenase-1 and iron in liver inflammation: a complex alliance Curr Drug Targets 11 2010 1541 1550
41. J.F. Ndisang, and A. Jadhav The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension Am J Physiol Regul Integr Comp Physiol 298 2010 211 223
42. P.A. Hosick, and D.E. Stec Heme oxygenase, a novel target for the treatment of hypertension and obesity? Am J Physiol Regul Integr Comp Physiol 302 2012 207 214