Nanocarrier systems for oral drug delivery: Do we really need them?

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 2, 2013, Pages 272-277

  Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Gastrointestinal stability; Nanocarrier systems; Nanoparticles; Oral drug delivery; Permeation; Solubility

Indexed keywords

ADSORBENT; APREPITANT; EMULSIFYING AGENT; FENOFIBRATE; MEGESTROL ACETATE; NANOCARRIER; NANOCRYSTAL; RAPAMYCIN; RIBOFLAVIN; SOLID LIPID NANOPARTICLE;

DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG METABOLISM; DRUG PENETRATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; DRUG UPTAKE; GASTROINTESTINAL ABSORPTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM;

ADMINISTRATION, ORAL; ANIMALS; DRUG CARRIERS; GASTROINTESTINAL TRACT; HUMANS; NANOPARTICLES; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 84876161904     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.03.008     Document Type: Review

References (39)

1. G. Ahuja, and K. Pathak Porous carriers for controlled/modulated drug delivery Indian J. Pharm. Sci. 71 2009 599 607
2. Y. Akiyama, N. Nagahara, E. Nara, M. Kitano, S. Iwasa, I. Yamamoto, J. Azuma, and Y. Ogawa Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites J. Pharm. Pharmacol. 50 1998 159 166
3. K. Albrecht, and A. Bernkop-Schnürch Thiomers: forms, functions and applications to nanomedicine Nanomedicine (Lond.) 2 2007 41 50
4. K. Albrecht, M. Greindl, B. Deutel, C. Kremser, C. Wolf, H. Talasz, M.M. Stollenwerk, P. Debbage, and A. Bernkop-Schnürch In vivo investigation of thiomer-polyvinylpyrrolidon nanoparticles using magnetic resonance imaging J. Pharm. Sci. 99 2008 2008 2017
5. D. Attivi, I. Ajana, A. Astier, B. Demoré, and S. Gibaud Development of microemulsion of mitotane for improvement of oral bioavailability Drug Dev. Ind. Pharm. 36 2010 421 427
6. M.M. Bandivadeka, S.S. Pancholi, R. Kaul-Ghanekar, A. Choudhari, and S. Koppikar Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug Drug Dev. Ind. Pharm. 38 2012 883 892
7. Bandivadekar, M.; Pancholi, S.; Kaul-Ghanekar, R.; Choudhari, A.; Koppikar, S.; in press. Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: formulation, characterization, cytotoxicity and permeability enhancement study. Drug Dev. Ind. Pharm.
8. S. Beg, S. Swain, H.P. Singh, Ch.N. Patra, and M.E. Rao Development, optimization, and characterization of solid self-nanoemulsifying drug delivery systems of valsartan using porous carriers AAPS PharmSciTech. 13 2012 1416 1427
9. S. Beg, S.S. Jena, Ch.N. Patra, M. Rizwan, S. Swain, J. Sruti, M.E. Rao, and B. Singh Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential Colloids Surf. B Biointerfaces 101 2013 414 423
10. A. Bernkop-Schnürch, C. Paikl, and C. Valenta Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N Pharm. Res. 14 1997 917 922
11. A. Christiansen, T. Backensfeld, and W. Weitschies Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes Eur. J. Pharm. Sci. 41 2010 376 382
12. R. Cone Mucus W.S. Michael, E. Lamm, Lloyd Mayer, Jerry R. McGhee, John Bienenstock, Jiri Mestecky, Mucosal Immunology 1999 Academic Press San Diego 43 64
13. A.J. Coupe, S.S. Davis, and I.R. Wilding Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects Pharm. Res. 8 1991 360 364
14. A. des Rieux, E.G. Ragnarsson, E. Gullberg, V. Préat, Y.J. Schneider, and P. Artursson Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium Eur. J. Pharm. Sci. 25 2005 455 465
15. A.T. Florence The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual Pharm. Res. 14 1997 259 266
16. A.T. Florence, A.M. Hillery, N. Hussain, and P.U. Jani Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence J. Drug Target. 3 1995 65 70
17. H. Harde, M. Das, and S. Jain Solid lipid nanoparticles: an oral bioavailability enhancer vehicle Expert Opin. Drug Deliv. 8 2011 1407 1424
18. Hintzen, F.; Laffleur, F.; Perera, G.; Müller, C.; Bernkop-Schnürch, A.; 2012. Protection of leuprorelin against enzymatic degradation by a self-microemulsifying drug delivery system (SMEDDS). In: XI International Conference on Nanostructured Materials, Rhodos, Greece.
19. X. Hu, C. Lin, D. Chen, J. Zhang, Z. Liu, W. Wu, and H. Song Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation Int. J. Pharm. 438 2012 123 133
20. A.C. Hunter, J. Elsom, P.P. Wibroe, and S.M. Moghimi Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective Nanomedicine Suppl. 1 2012 S15 20
21. J. Iqbal, D. Sakloetsakun, and A. Bernkop-Schnürch Thiomers: inhibition of cytochrome P450 activity Eur. J. Pharm. Biopharm. 78 2011 361 365
22. J.U. Junghanns, and R.H. Müller Nanocrystal technology, drug delivery and clinical applications Int. J. Nanomedicine 3 2008 295 309
23. S.K. Lai, Y.Y. Wang, and J. Hanes Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Deliv. Rev. 61 2009 158 171
24. S.K. Lai, Y.Y. Wang, K. Hida, R. Cone, and J. Hanes Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses Proc. Natl. Acad. Sci. USA 107 2010 598 603
25. X. Lin Release-controlling absorption enhancement of enterally administered Ophiopogon japonicus polysaccharide by sodium caprate in rats J. Pharm. Sci. 95 2006 2534 2542
26. H.L. Luessen, B.J. de Leeuw, M.W. Langemeÿer, A.B. de Boer, J.C. Verhoef, and H.E. Junginger Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo Pharm. Res. 13 1996 1668 1672
27. Müller, C.; 2013. Thesis. University of Innsbruck, Austria.
28. R.H. Müller, S. Gohla, and C.M. Keck State of the art of nanocrystals - special features, production, nanotoxicology aspects and intracellular delivery Eur. J. Pharm. Biopharm. 78 2011 1 9
29. Müller, C.; Leithner, K.; Hauptstein, S.; Hintzen, F.; Salvenmoser, W.; Bernkop-Schnürch, A.; 2013. Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications. J. Nanopart. Res. 15, 1353.
30. S.S. Olmsted, J.L. Padgett, A.I. Yudin, K.J. Whaley, T.R. Moench, and R.A. Cone Diffusion of macromolecules and virus-like particles in human cervical mucus Biophys. J. 81 2001 1930 1937
31. S.V. Rao, P. Agarwal, and J. Shao Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: II. In vitro transport study Int. J. Pharm. 362 2008 10 15
32. S.V. Rao, K. Yajurvedi, and J. Shao Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study Int. J. Pharm. 362 2008 16 19
33. A. Sparreboom, J. Verweij, M.E. van der Burg, W.J. Loos, E. Brouwer, L. Viganò, A. Locatelli, A.I. de Vos, K. Nooter, G. Stoter, and L. Gianni Disposition of Cremophor EL in humans limits the potential for modulation of the multidrug resistance phenotype in vivo Clin. Cancer Res. 4 1998 1937 1942
34. H. Takeuchi, Y. Matsui, H. Yamamoto, and Y. Kawashima Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats J. Control. Release 86 2003 235 242
35. M. Thanou, J.C. Verhoef, and H.E. Junginger Chitosan and its derivatives as intestinal absorption enhancers Adv. Drug Deliv. Rev. 50 Suppl. 1 2001 S91 101
36. B. Wahlang, D. Kabra, Y.B. Pawar, K. Tikoo, and A.K. Bansal Contribution of formulation and excipients towards enhanced permeation of curcumin Arzneimittelforschung 62 2012 88 93
37. Y. Wu, A. Loper, E. Landis, L. Hettrick, L. Novak, K. Lynn, C. Chen, K. Thompson, R. Higgins, U. Batra, S. Shelukar, G. Kwei, and D. Storey The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human Int. J. Pharm. 285 2004 135 146
38. W. Wu, Y. Wang, and L. Que Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system Eur. J. Pharm. Biopharm. 63 2006 288 294
39. V. Zabaleta, G. Ponchel, H. Salman, M. Agüeros, C. Vauthier, and J.M. Irache Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study Eur. J. Pharm. Biopharm. 81 2012 514 523