Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2683-2687

  Jiang, Rong ^a   Frackowiak, Bozena ^a   Shin, Youseung ^a   Song, Xinyi ^a   Chen, Weimin ^a   Lin, Li ^a   Cameron, Michael D ^a   Duckett, Derek R ^a   Kamenecka, Theodore M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ARYL 5 ANILINOINDAZOLE DERIVATIVE; 2 AMINOBENZIMIDAZOLE; 5 ANILINOINDAZOLE; BENZIMIDAZOLE; ETHYL 3(5 AMINO 1H INDAZOL 1 YL) BENZOATE; INDAZOLE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANIMALS; BRAIN; DRUG DESIGN; HALF-LIFE; INDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 8; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876155987     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.082     Document Type: Article

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