Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5521-5527

  Bowers, Simeon ^a   Truong, Anh P ^a   Jeffrey Neitz, R ^a   Hom, Roy K ^a   Sealy, Jennifer M ^a   Probst, Gary D ^a   Quincy, David ^a   Peterson, Brian ^a   Chan, Wayman ^a   Galemmo Jr , Robert A ^a   Konradi, Andrei W ^a   Sham, Hing L ^a   Tóth, Gergely ^a   Pan, Hu ^a   Lin, May ^a   Yao, Nanhua ^a   Artis, Dean R ^a   Zhang, Heather ^a   Chen, Linda ^a   Dryer, Mark ^a   Samant, Bhushan ^a   Zmolek, Wes ^a   Wong, Karina ^a   Lorentzen, Colin ^a   Goldbach, Erich ^a   Tonn, George ^a   Quinn, Kevin P ^a   Sauer, John Michael ^a   Wright, Sarah ^a   Powell, Kyle ^a   Ruslim, Lany ^a   Ren, Zhao ^a   Bard, Frédérique ^a   Yednock, Ted A ^a   Griswold Prenner, Irene ^a   more..

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

c Jun N terminal kinase inhibitor; JNK; Neurodegeneration; Trisubstituted thiophene

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ARTICLE; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MOUSE; NERVE DEGENERATION; NONHUMAN; RAT;

ANIMALS; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HALF-LIFE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NERVE DEGENERATION; PROTEIN KINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 80051924264     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.100     Document Type: Article

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