Angiotensin converting enzyme inhibitory activity of soy protein subjected to selective hydrolysis and thermal processing

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 14, 2013, Pages 3460-3467

  Margatan, Wynnie ^a   Ruud, Kirsten ^a   Wang, Qian ^a   Markowski, Todd ^a   Ismail, Baraem ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

conglycinin; angiotensin converting enzyme (ACE); antihypertensive peptides; glycinin; soy protein hydrolysate

Indexed keywords

ANGIOTENSIN-CONVERTING ENZYME; ANTIHYPERTENSIVE PEPTIDES; CONGLYCININ; GLYCININ; SOY PROTEIN HYDROLYSATE;

BIOLOGICAL MATERIALS; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PAPAIN; PEPTIDES;

ENZYME ACTIVITY;

GLYCINE MAX;

ANTIHYPERTENSIVE AGENT; BETA-CONGLYCININ PROTEIN, GLYCINE MAX; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLOBULIN; GLYCININ; PAPAIN; PEPSIN A; PEPTIDE FRAGMENT; PLANT ANTIGEN; SEED STORAGE PROTEIN; SOYBEAN PROTEIN;

ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG DEVELOPMENT; FOOD HANDLING; HEAT; KINETICS; METABOLISM; PROTEIN DEGRADATION; RABBIT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIGENS, PLANT; ANTIHYPERTENSIVE AGENTS; DRUG DISCOVERY; FOOD HANDLING; GLOBULINS; HOT TEMPERATURE; KINETICS; PAPAIN; PEPSIN A; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; PROTEOLYSIS; RABBITS; SEED STORAGE PROTEINS; SOYBEAN PROTEINS;

EID: 84876150414     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4001555     Document Type: Article

References (40)

1. De Leo, F.; Panarese, S.; Gallerani, R.; Ceci, L. R. Angiotensin converting enzyme (ACE) inhibitory peptides: production and implementation of functional food Curr. Pharm. Design. 2009, 15, 3622-3643
2. Hernandez-Ledesma, B.; del Mar Contreras, M.; Recio, I. Antihypertensive peptides: production, bioavailability and incorporation into foods Adv. Colloid Interface Sci. 2011, 165, 23-35
3. Pena-Ramos, E. A.; Xiong, Y. L. Antioxidant activity of soy protein hydrolysates in a liposomal system J. Food Sci. 2002, 67, 2952-2956
4. Kim, S. E.; Kim, H. H.; Kim, J. Y.; Kang, Y. I.; Woo, H. J.; Lee, H. J. Anticancer activity of hydrophobic peptides from soy proteins BioFactors 2000, 12, 151-155
5. Wu, J.; Ding, X. Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats J. Agric. Food Chem. 2001, 49, 501-506
6. American Heart Association (AHA). Heart disease and stroke statistic-2009 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation 2009, 119, e21-e181.
7. Natesh, R.; Schwager, S. L.; Sturrock, E. D.; Acharya, K. R. Crystal structure of the human angiotensin-converting enzyme-lisinopril complex Nature 2003, 421, 551-554
8. Korhonen, H.; Pihlanto, A. Food-derived bioactive peptides-opportunities for designing future foods Curr. Pharm. Design 2003, 9, 1297-1308
9. Gibbs, B. F.; Zougman, A.; Masse, R.; Mulligan, C. Productions and characterization of bioactive peptides from soy hydrolysate and soy-fermented foods Food Res. Int. 2004, 37, 123-131
10. Chen, J.; Okada, T.; Muramoto, K.; Suetsuna, K.; Yang, S. Identification of angiotensin 1-converting enzyme inhibitory peptides derived from the peptic digest of soybean protein J. Food Biochem. 2003, 26, 543-554
11. Chen, J. R.; Yang, S. C.; Suetsuna, K.; Chao, J. C. J. Soybean protein-derived hydrolysate affects blood pressure in spontaneously hypertensive rats J. Food Biochem. 2004, 28, 61-73
12. Lovati, M. R.; Manzoni, C.; Corsini, A.; Granata, A.; Fumagalli, R.; Sirtori, C. R. 7S globulin from soybean is metabolized in human cell cultures by a specific uptake and degradation system J. Nutr. 1996, 126, 2831-2842
13. Manzoni, C.; Duranti, M.; Eberini, I.; Scharnag, H.; Maerz, W.; Castiglioni, S.; Lovati, M. R. Subcellular localization of soybean 7S globulin in HepG2 cells and LDL receptor Up-regulation by its α′ constituents subunit J. Nutr. 2003, 133, 2149-2155
14. Martinez-Villaluenga, C.; Bringe, N. A.; Berhow, M. A.; Gonzales de Mejia, E. β-conglycinin embeds active peptides that inhibit lipid accumulation in 3T3-L1 adipocytes in vitro J. Agric. Food Chem. 2008, 56, 10533-10543
15. Martinez-Villaluenga, C.; Rupasinghe, S. G.; Schuler, M. A.; Gonzales de Mejia, E. Peptides from purified soybean β-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain FEBS J. 2010, 277, 1481-1493
16. Gonzalez de Mejia, E.; Martinez-Villaluenga, C.; Bringe, N. A. Fatty acid synthase and in vitro adipogenic response of human adipocytes inhibited by α and α′ subunits of soybean β-conglycinin hydrolysates by α and α′ subunits of soybean β-conglycinin hydrolysates Food Chem. 2010, 119, 1571-1577
17. Martinez-Villaluenga, C.; Dia, V. P.; Berhow, M. A.; Bring, N. A.; Gonzales de Mejia, E. Protein hydrolysates from β-conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro Mol. Nutr. Food Res. 2009, 53, 1007-1018
18. Wang, W.; Bring, N. A.; Berhow, M. A.; Gonzales de Mejia, E. β-Conglycinin among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro J. Agric. Food Chem. 2008, 56, 4012-4020
19. Tsumura, K.; Saito, T.; Kugimiya, W.; Inouye, K. Selective proteolysis of the glycinin and β-conglycinin fractions in a soy protein isolate by pepsin and papain with controlled pH and temperature J. Food Sci. 2004, 69, C363-C367
20. 3 J. Food Sci. 2006, 71, C413-C424
21. Tang, C. H.; Choi, S. M.; Ma, C. Y. Study of thermal properties and heat-induced denaturation and aggregation of soy proteins by modulated differential scanning calorimetry Int. J. Biol. Macromol. 2007, 40, 96-104
22. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 1970, 227, 680-685
23. Nielsen, P. M.; Petersen, D.; Dambmann, C. Improved method for determining food protein degree of hydrolysis J. Food Sci. 2001, 66, 642-646
24. Adler-Nissen, J. Control of the proteolytic reaction and of the level of bitterness in protein hydrolysis processes J. Chem. Technol. Biotechnol. 1984, 34B, 215-222
25. Otte, J.; Shalaby, S. M.; Zakora, M.; Pripp, A. H.; El-Shabrawy, S. A. Angiotensin-converting enzyme inhibitory activity of milk protein hydrolysates: effect of substrate, enzyme and time of hydrolysis Int. Dairy J. 2007, 17, 488-503
26. Shalaby, S. M.; Zakora, M.; Otte, J. Performance of two commonly used angiotensin-converting enzyme inhibition assay using FA-PGG and HHL as substrate J. Dairy Res. 2006, 73, 178-186
27. Bunning, P. The catalytic mechanism of angiotensin converting enzyme Clin. Exp. Hypertens., Part A 1983, 5, 1263-1275
28. Holmquist, B.; Bunning, P.; Riordan, J. E. A continuous spectrophotometric assay for the angiotensin converting enzyme Anal. Biochem. 1979, 95, 40-48
29. Vermeirssen, V.; van Camp, J.; Verstraete, W. Optimization and validation of an angiotensin-converting enzyme inhibition assay for the screening of bioactive peptides J. Biochem. Biophys. Methods 2003, 51, 75-87
30. Keller, A.; Nesvizhdkii, A. I.; Kolker, E.; Aebersold, R. Emperical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search Anal. Chem. 2002, 74, 5383-5392
31. Nesvizhskii, A. I.; Keller, A.; Kolker, E.; Aebersold, R. A statistical model for identifying proteins by tandem mass spectrometry Anal. Chem. 2003, 75, 4646-4658
32. Statistical Program for Social Sciences (SPSS).SPSS for Windows, release 17; SPSS Inc., Chicago, IL, 2010.
33. Damodaran, S. Refolding of thermally unfolded soy proteins during the cooling regime of gelation process: effect on gelation J. Agric. Food Chem. 1988, 36, 262-269
34. Lamsal, B. P.; Sung, S.; Johnson, L. A. Rheological properties of soy protein hydrolysates obtained from limited enzymatic hydrolysis Lebensm. Wiss. Technol. 2007, 40, 1215-1223
35. Matoba, T.; Hata, T. Relationship between bitterness of peptides and their chemical structures Agric. Biol. Chem. 1972, 36, 1423-1431
36. Chiang, W. D.; Tsou, M. J.; Tsai, Z. Y.; Tsai, T. C. Angiotensin 1-converting enzyme inhibitor derived from soy protein hydrolysate and produced by using membrane reactor Food Chem. 2006, 98, 725-732
37. Lo, W. M. Y.; Farnworth, E. R.; Li-Chan, E. C. Y. Angiotensin 1-converting enzyme inhibitory activity of soy protein digests in a dynamic model system simulating the upper gastrointestinal tract J. Food Sci. 2006, 71, S231-S237
38. Lo, W. M. Y.; Li-Chan, E. C. Y. Angiotensin 1-converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digetsion of soy protein J. Agric. Food Chem. 2005, 53, 3369-3376
39. Cha, M.; Park, J. R. Production and characterization of a soy protein-derived angiotensin I-converting enzyme inhibitory hydrolysate J. Med. Food 2005, 8, 305-310
40. Wu, J.; Ding, X. Characterization of inhibition and stability of soy-protein derived angiotensin 1-converting enzyme inhibitory peptides Food Res. Int. 2002, 35, 367-375