An in-vacuum, pixelated detection system for mass spectrometric analysis and imaging of macromolecules

International Journal of Mass Spectrometry

Volumn 341-342, Issue , 2013, Pages 34-44

  Jungmann, Julia H ^a   Smith, Donald F ^a   Kiss, Andras ^a   MacAleese, Luke ^a,b   Buijs, Ronald ^a   Heeren, Ron M A ^a  

^a FOM INSTITUTE AMOLF   (Netherlands)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Gigabit read out; High m z; High spatial resolution; High voltage; Imaging mass spectrometry; In vacuum mounting; Intact protein; MALDI; Mass spectrometry imaging; MCP; Microscope mode; Multiplexed TDC; Pixelated detector; Timepix

Indexed keywords

EID: 84876147869     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2013.02.010     Document Type: Article

References (35)

1. L.A. McDonnell, and R.M.A. Heeren Mass spectrometry imaging Mass Spectrometry Reviews 26 2007 606 643
2. K. Chughtai, and R.M.A. Heeren Mass spectrometric imaging for biomedical tissue analysis Chemical Reviews 110 2010 3237 3277
3. J.H. Jungmann, and R.M.A. Heeren Emerging technologies in mass spectrometry imaging Journal of Proteomics 2012
4. R.D. Chen, X.H. Cheng, D.W. Mitchell, S.A. Hofstadler, Q.Y. Wu, A.L. Rockwood, M.G. Sherman, and R.D. Smith Trapping, detection, and mass determination of coliphage T4 DNA ions of 10(8) Da by electrospray-ionization Fourier-transform ion-cyclotron resonance mass-spectrometry Analytical Chemistry 67 1995 1159 1163
5. S. Sanglier, E. Leize, A. Van Dorsselaer, and F. Zal Comparative ESI-MS study of similar to 2.2 MDa native hemocyanins from deep-sea and shore crabs: from protein oligomeric state to biotope Journal of the American Society for Mass Spectrometry 14 2003 419 429 (Pubitemid 36871623)
6. R.J. Rose, E. Damoc, E. Denisov, A. Makarov, and A.J.R. Heck High-sensitivity orbitrap mass analysis of intact macromolecular assemblies Nature Methods 9 2012 1084 1086
7. F. DiFilippo, V. Natarajan, M. Bradley, F. Palmer, and D.E. Pritchard Accurate atomic mass measurements from Penning trap mass comparisons of individual ions Physica Scripta T59 1995
8. S.D. Fuerstenau, and W.H. Benner Molecular weight determination of megadalton DNA electrospray ions using charge detection time-of-flight mass spectrometry Rapid Communications in Mass Spectrometry 9 1995 1528 1538 (Pubitemid 3007796)
9. T. Doussineau, C.Y. Bao, R. Antoine, P. Dugourd, W.J. Zhang, F. D'Agosto, and B. Charleux Direct molar mass determination of self-assembled amphiphilic block copolymer nanoobjects using electrospray-charge detection mass spectrometry ACS Macro Letters 1 2012 414 417
10. M.A. Park, and J.H. Callahan An inductive detector for time-of-flight mass-spectrometry Rapid Communications in Mass Spectrometry 8 1994 317 322
11. D.W. Chandler, and P.L. Houston Two-dimensional imaging of state-selected photodissociation products detected by multiphoton ionization Journal of Chemical Physics 87 1987 1445 1447
12. B. Spengler, D. Kirsch, R. Kaufmann, M. Karas, F. Hillenkamp, and U. Giessmann The detection of large molecules in matrix-assisted Uv-laser desorption Rapid Communications in Mass Spectrometry 4 1990 301 305
13. R.J. Wenzel, S. Kern, and R. Zenobi Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics Seattle, USA 2006
14. A. van Remoortere, R.J.M. van Zeijl, N. van den Oever, J. Franck, R. Longuespee, M. Wisztorski, M. Salzet, A.M. Deelder, I. Fournier, and L.A. McDonnell MALDI imaging and profiling MS of higher mass proteins from tissue Journal of the American Society for Mass Spectrometry 21 2010 1922 1929
15. H. Kraus Cryogenic detectors and their application to mass spectrometry International Journal of Mass Spectrometry 215 2002 45 58
16. M. Frank, S.E. Labov, G. Westmacott, and W.H. Benner Energy-sensitive cryogenic detectors for high-mass biomolecule mass spectrometry Mass Spectrometry Reviews 18 1999 155 186 (Pubitemid 129660485)
17. M. Frank Mass spectrometry with cryogenic detectors Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 444 2000 375 384
18. S.L.M. Luxembourg, T.H. McDonnell, and L.A.R.M.A. Heeren High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface Analytical Chemistry 76 2004 5339 5344
19. J.H. Jungmann, L. MacAleese, R. Buijs, F. Giskes, A. de Snaijer, J. Visser, J. Visschers, M.J.J. Vrakking, and R.M.A. Heeren Fast, high resolution mass spectrometry imaging using a Medipix pixelated detector Journal of the American Society for Mass Spectrometry 21 2010 2023 2030
20. J.H. Jungmann, L. MacAleese, J. Visser, M.J.J. Vrakking, and R.M.A. Heeren High dynamic range bio-molecular ion microscopy with the Timepix detector Analytical Chemistry 83 2011 7888 7894
21. J.H. Jungmann, D.F. Smith, L. MacAleese, I. Klinkert, J. Visser, and R.M.A. Heeren Biological tissue imaging with a position and time sensitive pixelated detector Journal of the American Society for Mass Spectrometry 23 2012 1679 1688
22. G. Gademann, Y. Gijsbertsen, A. Jungmann, J. Visschers, and J.M.J.J. Vrakking Velocity map imaging using an in-vacuum pixel detector Review of Scientific Instruments 8 2009 103105 103107
23. C. Bamberger, U. Renz, and A. Bamberger Digital imaging mass spectrometry Journal of the American Society for Mass Spectrometry 22 2011 1079 1087
24. X.C. Llopart, M. Dinapoli, R. San Segundo, and D.E. Pernigotti Medipix2, a 64k pixel readout chip with 55micron square elements working in single photon counting mode IEEE Trans Nuclear Science 49 2002 2279 2283
25. X.C. Llopart M First test measurements of a 64k pixel readout chip working in single photon counting mode Nuclear Instruments and Methods A 509 2003 157 163
26. X. Llopart, R. Ballabriga, M. Campbell, L. Tlustos, and W. Wong Timepix, a 65k programmable pixel readout chip for arrival time, energy and/or photon counting measurements Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 581 2007 485 494 (Pubitemid 47576358)
27. J.M. Vallerga, J. Tremsin, A. Siegmund, O. Mikulec, and B.A. Clark Optically sensitive Medipix2 detector for adaptive optics wavefront sensing Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers Detectors and Associated Equipment 546 2005 263 269
28. T.J. Holy, J. Pospisil, S. Uher, J. Vavrik, and D.Z. Vykydal Data acquisition and processing software package for Medipix2 Nuclear Instruments and Methods A 1 2006
29. D. Turecek, T. Holy, J. Jakubek, S. Pospisil, and Z. Vykydal Pixelman: a multi-platform data acquisition and processing software package for Medipix2, Timepix and Medipix3 detectors Journal of Instruments 6 2011
30. M. Campbell 10 years of the Medipix2 Collaboration Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 633 2011 S1 S10
31. B.W. Schueler Microscope imaging by time-of-flight secondary ion mass spectrometry Microscopy Microanalysis Microstructures 3 1992 119 139
32. Z.V. Vykydal, J. Sabuncuoglu Tezcan, D. De Munck, K. Borgers, T. Ruythooren, and W.P. De Moor The RELAXd project: development of four-side tilable photon-counting imagers Nuclear Instruments and Methods A 591 2008 241 244
33. J. Visser, B. van der Heijden, S.J.A. Weijers, R. de Vries, and J.L. Visschers A Gigabit per second read-out system for Medipix Quads Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 633 2011 S22 S25
34. D.P. Fries, S.Z. Ivanov, H.A. Broadbent, R. Willoughby, and E. Sheehan Micro ion-optical systems technology [MIST] for mass spectrometry using PCBMEMS International Symposium on Industrial Electronics, 2007. ISIE 2007 2007 3278 3281
35. T. Holy, J. Jakubek, S. Pospisil, J. Uher, D. Vavrik, and Z. Vykydal Data acquisition and processing software package for Medipix2 Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers Detectors and Associated Equipment 563 2006 254 258 (Pubitemid 43867003)