A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2663-2670

  Andaloussi, Mounir ^a   Lim, Herman D ^a   Van Der Meer, Tiffany ^a   Sijm, Maarten ^a   Poulie, Chris B M ^a   De Esch, Iwan J P ^a   Leurs, Rob ^a   Smits, Rogier A ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

GPCR; hERG; Histamine H4 receptor; PF 3893787; Pyrido 3,2 d pyrimidine; Residence time

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; PF 3893787; POTASSIUM CHANNEL HERG; PYRIDO[3,2 D]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE;

ANIMALS; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HALF-LIFE; HISTAMINE ANTAGONISTS; HUMANS; INDOLES; KINETICS; MICE; PIPERAZINES; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; PYRROLIDINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 84876144199     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.091     Document Type: Article

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