Pancreatic neuroendocrine tumors: Clinical features, diagnosis and medical treatment: Advances

Best Practice and Research: Clinical Gastroenterology

Volumn 26, Issue 6, 2012, Pages 737-753

  Ito, Tetsuhide ^a,b   Igarashi, Hisato ^a,b   Jensen, Robert T ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Gastrinoma; Glucagonoma; Growth hormone releasing factor secreting tumor (GRPoma); Hypergastrinemia; hypoglycemia; Insulinoma; Multiple endocrine neoplasia type 1(MEN1); Neuroendocrine tumor (NET); Neurofibromatosis 1(NF 1); Nonfunctional pancreatic endocrine tumor (NF pNET); Pancreatic neuroendocrine tumor (pNET); Pancreatic polypeptide secreting tumor (PPoma); Somatostatinoma; Tuberous sclerosis; VIPoma; Von Hippel Lindau disease (VHL); Von Recklinghausen's disease; Zollinger Ellison syndrome (ZES)

Indexed keywords

ANGIOPEPTIN; CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT; CIMETIDINE; DIAZOXIDE; ESOMEPRAZOLE; EVEROLIMUS; FAMOTIDINE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; LANSOPRAZOLE; MOTILIN; NEURON SPECIFIC ENOLASE; NEUROTENSIN; NIZATIDINE; OCTREOTIDE; OMEPRAZOLE; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PANTOPRAZOLE; PEPTIDE YY; RABEPRAZOLE; RANITIDINE;

ACHLORHYDRIA; ARTICLE; CANCER DIAGNOSIS; CANCER PROGNOSIS; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CYTOREDUCTIVE SURGERY; DIFFERENTIAL DIAGNOSIS; DRUG MEGADOSE; DRUG SAFETY; ENDOCRINE TUMOR; FLUID RETENTION; FRACTURE; GASTROINTESTINAL ENDOSCOPY; GLUCAGONOMA; HIRSUTISM; HUMAN; HYPERALIMENTATION; HYPOGLYCEMIA; INSULINOMA; LONG TERM CARE; MULTIPLE ENDOCRINE NEOPLASIA; NAUSEA; NEUROFIBROMATOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREATIC NEUROENDOCRINE TUMOR; PHOTON EMISSION TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY; SIDE EFFECT; SOMATOSTATINOMA; TUBEROUS SCLEROSIS; TUMOR LOCALIZATION; ULTRASOUND; VERNER MORRISON SYNDROME; VIPOMA; VON HIPPEL LINDAU DISEASE; ZOLLINGER ELLISON SYNDROME;

EID: 84876110528     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2012.12.003     Document Type: Review

References (109)

1. K. Oberg Pancreatic endocrine tumors Semin Oncol 37 2010 594 618
2. D.C. Metz, and R.T. Jensen Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors Gastroenterology 135 2008 1469 1492
3. T. Ito, H. Igarashi, and R.T. Jensen Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances J Gastroenterol 47 2012 941 960
4. R.T. Jensen, G. Cadiot, M.L. Brandi, W.W. de Herder, G. Kaltsas, and P. Komminoth ENETS consensus guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes Neuroendocrinology 95 2012 98 119
5. M.H. Kulke, L.B. Anthony, D.L. Bushnell, W.W. de Herder, S.J. Goldsmith, and D.S. Klimstra NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas Pancreas 39 2010 735 752
6. G. Kloppel Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms Endocr Relat Cancer 18 Suppl. 1 2011 S1 S16
7. M. Pavel, E. Baudin, A. Couvelard, E. Krenning, K. Oberg, and T. Steinmuller ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary Neuroendocrinology 95 2012 157 176
8. M.H. Kulke, A.B. Benson III, E. Bergsland, J.D. Berlin, L.S. Blaszkowsky, and M.A. Choti Neuroendocrine tumors J Natl Compr Canc Netw 10 2012 724 764
9. M. Chen, M. Van Ness, Y. Guo, and J. Gregg Molecular pathology of pancreatic neuroendocrine tumors J Gastrointest Oncol 3 2012 182 188
10. L.C. Huang, G.A. Poultsides, and J.A. Norton Surgical management of neuroendocrine tumors of the gastrointestinal tract Oncol (Williston Park) 25 2011 794 803
11. M. Falconi, D.K. Bartsch, B. Eriksson, G. Kloppel, J.M. Lopes, and J.M. O'connor ENETS consensus guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non-functioning tumors Neuroendocrinology 95 2012 120 134
12. D.S. Klimstra, I.R. Modlin, D. Coppola, R.V. Lloyd, and S. Suster The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems Pancreas 39 2010 707 712
13. H.C. Chiang, T.M. O'Dorisio, S.C. Huang, P.N. Maton, J.D. Gardner, and R.T. Jensen Multiple hormone elevations in patients with Zollinger-Ellison syndrome: prospective study of clinical significance and of the development of a second symptomatic pancreatic endocrine tumor syndrome Gastroenterology 99 1990 1565 1575
14. D. O'Toole, A. Grossman, D. Gross, G. Delle Fave, J. Barkmanova, and J. O'Connor ENETS consensus guidelines for the standards of care in neuroendocrine tumors: biochemical markers Neuroendocrinology 90 2009 194 202
15. B. Eriksson, K. Oberg, and B. Skogseid Neuroendocrine pancreatic tumors. Clinical findings in a prospective study of 84 patients Acta Oncol 28 1989 373 377
16. I. Samyn, C. Fontaine, F. Van Tussenbroek, M. Pipeleers-Marichal, and J. De Greve Paraneoplastic syndromes in cancer: case 1. Polycythemia as a result of ectopic erythropoietin production in metastatic pancreatic carcinoid tumor J Clin Oncol 22 2004 2240 2242
17. M.C. Ruddy, S.A. Atlas, and F.G. Salerno Hypertension associated with a renin-secreting adenocarcinoma of the pancreas N Engl J Med 307 1982 993 997
18. R.E. Roberts, M. Zhao, B.C. Whitelaw, J. Ramage, S. Diaz-Cano, and C.W. le Roux GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia J Clin Endocrinol Metab 97 2012 3039 3045
19. J.O. Chung, S.I. Hong, D.H. Cho, J.H. Lee, D.J. Chung, and M.Y. Chung Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report Endocrinol Jpn 2008
20. G. Piaditis, A. Angellou, G. Kontogeorgos, N. Mazarakis, T. Kounadi, and G. Kaltsas Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries J Clin Endocrinol Metab 90 2005 2097 2103
21. E. Brignardello, R. Manti, M. Papotti, E. Allia, D. Campra, and G. Isolato Ectopic secretion of LH by an endocrine pancreatic tumor J Endocrinol Invest 27 2004 361 365
22. M.M. Byrne, G.P. McGregor, P. Barth, M. Rothmund, B. Goke, and R. Arnold Intestinal proliferation and delayed intestinal transit in a patient with a GLP-1-, GLP-2- and PYY-producing neuroendocrine carcinoma Digestion 63 2001 61 68
23. F.M. Stevens, R.W. Flanagan, D. O'Gorman, and K.D. Buchanan Glucagonoma syndrome demonstrating giant duodenal villi Gut 25 1984 351 354
24. S.R. Bloom An enteroglucagon tumour Gut 13 1972 520 523
25. W.B. Vanderlan, Z. Zhang, and M.S. Abouljoud Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with siemens' double glucagon antibody and dakocytomation's polyclonal rabbit anti-human glucagon: a case report J Med Case Rep 4 2010 178
26. A. Fleury, J.F. Flejou, A. Sauvanet, G. Molas, C. Vissuzaine, and P. Hammel Calcitonin-secreting tumors of the pancreas: about six cases Pancreas 16 1998 545 550
27. R. Schneider, J. Waldmann, Z. Swaid, A. Ramaswamy, V. Fendrich, and D.K. Bartsch Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity Pancreas 40 2011 213 221
28. A.I. Vinik, W.E. Strodel, F.E. Eckhauser, A.R. Moattari, and R. Lloyd Somatostatinomas, PPomas, neurotensinomas Semin Oncol 14 1987 263 281
29. V. Amrilleva, E.P. Slater, J. Waldmann, D. Bonorden, and V. Fendrich A pancreatic polypeptide-producing pancreatic tumor causing WDHA syndrome Case Rep Gastroenterol 2 2008 238 243
30. G. Lundqvist, U. Krause, L.I. Larsson, L. Grimelius, O.B. Schaffalitzky de Muckadell, and J. Fahrenkrug A pancreatic-polypeptide-producing tumour associated with the WDHA syndrome Scand J Gastroenterol 13 1978 715 718
31. W.E. Strodel, A.I. Vinik, R.V. Lloyd, B. Glaser, F.E. Eckhauser, and R.G. Fiddian-Green Pancreatic polypeptide-producing tumors. Silent lesions of the pancreas? Arch Surg 119 1984 508 514
32. H.S. Wang, D.S. Oh, G.V. Ohning, and J.R. Pisegna Elevated serum ghrelin exerts an orexigenic effect that may maintain body mass index in patients with metastatic neuroendocrine tumors J Mol Neurosci 33 2007 225 231
33. T. Walter, L. Chardon, V. Hervieu, R. Cohen, J.A. Chayvialle, and J.Y. Scoazec Major hyperghrelinemia in advanced well-differentiated neuroendocrine carcinomas: report of three cases Eur J Endocrinol 161 2009 639 645
34. R.T. Jensen Overview of chronic diarrhea caused by functional neuroendocrine neoplasms Semin Gastrointest Dis 10 1999 156 172
35. J. Zhou, L. Enewold, A. Stojadinovic, G.T. Clifton, J.F. Potter, and G.E. Peoples Incidence rates of exocrine and endocrine pancreatic cancers in the United States Cancer Causes Control 21 2010 853 861
36. T. Ito, H. Sasano, M. Tanaka, R.Y. Osamura, I. Sasaki, and W. Kimura Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan J Gastroenterol 45 2010 234 243
37. L. Gullo, M. Migliori, M. Falconi, P. Pederzoli, R. Bettini, and R. Casadei Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study Am J Gastroenterol 98 2003 2435 2439
38. R.T. Jensen Natural history of digestive endocrine tumors M. Mignon, J.F. Colombel, Recent advances in pathophysiology and management of inflammatory bowel diseases and digestive endocrine tumors 1999 France:John Libbey Eurotext Publishing Co. Paris 192 219
39. J.A. Norton, and R.T. Jensen Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome Ann Surg 240 2004 757 773
40. F. Gibril, and R.T. Jensen Diagnostic uses of radiolabelled somatostatin-receptor analogues in gastroenteropancreatic endocrine tumors Dig Liver Dis 36 2004 S106 S120
41. M.T. Heller, and A.B. Shah Imaging of neuroendocrine tumors Radiol Clin North Am 49 2011 529 548 vii
42. A.G. Krudy, J.L. Doppman, R.T. Jensen, J.A. Norton, M.J. Collen, and T.H. Shawker Localization of islet cell tumors by dynamic CT: comparison with plain CT, arteriography, sonography and venous sampling Am J Roentgenol 143 1984 585 589
43. J.A. Cherner, J.L. Doppman, J.A. Norton, D.L. Miller, A.G. Krudy, and J.P. Raufman Selective venous sampling for gastrin to localize gastrinomas. A prospective study Ann Intern Med 105 1986 841 847
44. J.L. Doppman, D.L. Miller, R. Chang, P.N. Maton, J.F. London, and J.D. Gardner Gastrinomas: localization by means of selective intraarterial injection of secretin Radiology 174 1990 25 29
45. H. Eguchi, M. Tanemura, S. Marubashi, S. Kobayashi, H. Wada, and K. Okita Arterial stimulation and venous sampling for glucagonomas of the pancreas Hepatogastroenterology 59 2011 276 279
46. R.T. Jensen, M.J. Berna, M.D. Bingham, and J.A. Norton Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management and controversies Cancer 113 Suppl. 7 2008 1807 1843
47. F. Gibril, Y.-J. Chen, D.S. Schrump, A. Vortmeyer, Z.P. Zhuang, and I.A. Lubensky Prospective study of thymic carcinoids in patients with multiple endocrine neoplasia type 1 J Clin Endocrinol Metab 88 2003 1066 1081
48. B. Asgharian, Y.J. Chen, N.J. Patronas, D.J. Venzon, P. Peghini, and J.C. Reynolds Meningiomas may be a component tumor of MEN1 Clin Cancer Res 10 2004 869 880
49. J.L. McKeeby, X. Li, Z. Zhuang, A.O. Vortmeyer, S. Huang, and M. Pirner Multiple leiomyomas of the esophagus, lung, and uterus in multiple endocrine neoplasia type 1 Am J Pathol 159 2001 1121 1127
50. B. Asgharian, M.L. Turner, F. Gibril, L.K. Entsuah, J. Serrano, and R.T. Jensen Cutaneous tumors in patients with MEN1 and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity J Clin Endocrinol Metab 89 2004 5328 5336
51. F. Gibril, M. Schumann, A. Pace, and R.T. Jensen Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome. A prospective study of 107 cases and comparison with 1009 patients from the literature Medicine (Baltimore) 83 2004 43 83
52. P.K. Roy, D.J. Venzon, H. Shojamanesh, A. Abou-Saif, P. Peghini, and J.L. Doppman Zollinger-Ellison syndrome: clinical presentation in 261 patients Medicine (Baltimore) 79 2000 379 411
53. M. Anlauf, N. Garbrecht, T. Henopp, A. Schmitt, R. Schlenger, and A. Raffel Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features World J Gastroenterol 12 2006 5440 5446
54. M. Pipeleers-Marichal, G. Somers, G. Willems, A. Foulis, C. Imrie, and A.E. Bishop Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome N Engl J Med 322 1990 723 727
55. M. Anlauf, A. Perren, and G. Kloppel Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance Pathobiology 74 2007 279 284
56. A.K. Thom, J.A. Norton, C.A. Axiotis, and R.T. Jensen Location, incidence and malignant potential of duodenal gastrinomas Surgery 110 1991 1086 1093
57. J.A. Norton, H.R. Alexander, D.L. Fraker, D.J. Venzon, and R.T. Jensen Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases or survival in patients with Zollinger-Ellison syndrome (ZES)? Ann Surg 239 2004 617 626
58. R.T. Jensen Management of the Zollinger-Ellison syndrome in patients with multiple endocrine neoplasia type 1 J Intern Med 243 1998 477 488
59. R.R. Lonser, G.M. Glenn, M. Walther, E.Y. Chew, S.K. Libutti, and W.M. Linehan von Hippel-Lindau disease Lancet 361 2003 2059 2067
60. P.R. Hammel, V. Vilgrain, B. Terris, A. Penfornis, A. Sauvanet, and J.M. Correas Pancreatic involvement in von Hippel-Lindau disease Gastroenterology 119 2000 1087 1095
61. S.K. Libutti, P.L. Choyke, H.R. Alexander, G. Glenn, D.L. Bartlett, and B. Zbar Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau disease Surgery 128 2000 1022 1027
62. R.E. Ferner Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective Lancet Neurol 6 2007 340 351
63. K.M. Hoffmann, M. Furukawa, and R.T. Jensen Duodenal neuroendocrine tumors: classification, functional syndromes, diagnosis and medical treatment Best Pract Res Clin Gastroenterol 19 2005 675 697
64. C. Mao, A. Shah, D.J. Hanson, and J.M. Howard Von Recklinghausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomas J Surg Oncol 59 1995 67 73
65. P.B. Crino, K.L. Nathanson, and E.P. Henske The tuberous sclerosis complex N Engl J Med 355 2006 1345 1356
66. C. Zhou, D. Dhall, N.N. Nissen, C.R. Chen, and R. Yu Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor Pancreas 38 2009 941 946
67. R. Yu, S.G. Ren, and J. Mirocha Glucagon receptor is required for long-term survival: a natural history study of the Mahvash disease in a murine model Endocrinol Nutr 59 2012 523 530
68. P. Stefanini, M. Carboni, N. Patrassi, and A. Basoli Beta-islet cell tumors of the pancreas: results of a study on 1,067 cases Surgery 75 1974 597 609
69. R.T. Jensen, and J.A. Norton Endocrine tumors of the pancreas and gastrointestinal tract M. Feldman, L.S. Friedman, L.J. Brandt, Sleisenger and Fordtran's gastrointestinal and liver disease 2010 Saunders Philadelphia 491 522
70. C.S. Grant Insulinoma Best Pract Res Clin Gastroenterol 19 2005 783 798
71. R. Marsk, E. Jonas, F. Rasmussen, and E. Naslund Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden Diabetologia 53 2010 2307 2311
72. F.J. Service, N. Natt, G.B. Thompson, C.S. Grant, J.A. Van Heerden, and J.C. Andrews Noninsulinoma pancreatogenous hypoglycemia:a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes J Clin Endocrinol Metab 84 1999 1582 1589
73. P.E. Cryer, L. Axelrod, A.B. Grossman, S.R. Heller, V.M. Montori, and E.R. Seaquist Evaluation and management of adult hypoglycemic disorders: an endocrine society clinical practice guideline J Clin Endocrinol Metab 94 2009 709 728
74. P.N. Goode, J.R. Farndon, J. Anderson, I.D. Johnston, and J.A. Morte Diazoxide in the management of patients with insulinoma World J Surg 10 1986 586 592
75. G.V. Gill, O. Rauf, and I.A. MacFarlane Diazoxide treatment for insulinoma: a national UK survey Postgrad Med J 73 1997 640 641
76. D. Vezzosi, A. Bennet, P. Rochaix, F. Courbon, J. Selves, and B. Pradere Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies Eur J Endocrinol 152 2005 757 767
77. M.H. Kulke, E.K. Bergsland, and J.C. Yao Glycemic control in patients with insulinoma treated with everolimus N Engl J Med 360 2009 195 197
78. H.B. Fiebrich, E.J. Siemerink, A.H. Brouwers, T.P. Links, W.S. Remkes, and G.A. Hospers Everolimus induces rapid plasma glucose normalization in insulinoma patients by effects on tumor as well as normal tissues Oncologist 16 2011 783 787
79. M.J. Levy, G.B. Thompson, M.D. Topazian, M.R. Callstrom, C.S. Grant, and A. Vella US-guided ethanol ablation of insulinomas: a new treatment option Gastrointest Endosc 75 2012 200 206
80. P.K. Roy, D.J. Venzon, K.M. Feigenbaum, P.D. Koviack, S. Bashir, and J.V. Ojeaburu Gastric secretion in Zollinger-Ellison syndrome: correlation with clinical expression, tumor extent and role in diagnosis - a prospective NIH study of 235 patients and review of the literature in 984 cases Medicine(Baltimore) 80 2001 189 222
81. R.T. Jensen Gastrointestinal endocrine tumors. Gastrinoma Bailliere's Clin Gastroenterol 10 1996 555 766
82. R.T. Jensen, B. Niederle, E. Mitry, J.K. Ramage, T. Steinmuller, and V. Lewington Gastrinoma (duodenal and pancreatic) Neuroendocrinology 84 2006 173 182
83. R.V. Benya, D.C. Metz, D.J. Venzon, V.A. Fishbeyn, D.B. Strader, and M. Orbuch Zollinger-Ellison syndrome can be the initial endocrine manifestation in patients with multiple endocrine neoplasia-type 1 Am J Med 97 1994 436 444
84. J.A. Norton, D.J. Venzon, M.J. Berna, H.R. Alexander, D.L. Fraker, and S.K. Libutti Prospective study of surgery for primary hyperaparathyroidism (HPT) in multiple endocrine neoplasia type 1 (MEN1), and Zollinger-Ellison syndrome (ZES): longterm outcome of a more virulent form of HPT Ann Surg 247 2008 501 510
85. M.J. Berna, K.M. Hoffmann, J. Serrano, F. Gibril, and R.T. Jensen Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature Medicine (Baltimore) 85 2006 295 330
86. T. Ito, G. Cadiot, and R.T. Jensen Diagnosis of Zollinger-Ellison syndrome: increasingly difficult World J Gastroenterol 18 2012 5495 5503
87. D.C. Metz Diagnosis of the Zollinger-Ellison syndrome Clin Gastroenterol Hepatol 10 2012 126 130
88. M.J. Berna, K.M. Hoffmann, S.H. Long, J. Serrano, F. Gibril, and R.T. Jensen Serum gastrin in Zollinger-Ellison syndrome:I I. Prospective study of gastrin provocative testing in 293 patients from the National Institutes of Health and comparison with 537 cases from the literature. Evaluation of diagnostic criteria, proposal of new criteria, and correlations with clinical and tumoral features Medicine (Baltimore) 85 2006 331 364
89. V.D. Corleto, B. Annibale, F. Gibril, S. Angeletti, J. Serrano, and D.J. Venzon Does the widespread use of proton pump inhibitors mask, complicate and/or delay the diagnosis of Zollinger-Ellison syndrome? Aliment Pharmacol Ther 15 2001 1555 1561
90. J.F. Rehfeld The art of measuring gastrin in plasma: a dwindling diagnostic discipline? Scand J Clin Lab Invest 68 2008 353 361
91. P. Poitras, M.H. Gingras, and J.F. Rehfeld The Zollinger-Ellison syndrome: dangers and consequences of interrupting antisecretory treatment Clin Gastroenterol Hepatol 10 2012 199 202
92. V.A. Fishbeyn, J.A. Norton, R.V. Benya, J.R. Pisegna, D.J. Venzon, and D.C. Metz Assessment and prediction of long-term cure in patients with Zollinger-Ellison syndrome: the best approach Ann Intern Med 119 1993 199 206
93. T. von Schrenck, J.M. Howard, J.L. Doppman, J.A. Norton, P.N. Maton, and F.P. Smith Prospective study of chemotherapy in patients with metastatic gastrinoma Gastroenterology 94 1988 1326 1334
94. T. Ito, H. Igarashi, H. Uehara, and R.T. Jensen Pharmacotherapy of Zollinger-Ellison syndrome Expert Opin Pharmacotherapy 14 2013 307 321
95. D.C. Metz, J.R. Pisegna, V.A. Fishbeyn, R.V. Benya, K.M. Feigenbaum, and P.D. Koviack Currently used doses of omeprazole in Zollinger-Ellison syndrome are too high Gastroenterology 103 1992 1498 1508
96. 12 levels in patients with Zollinger-Ellison syndrome Am J Med 104 1998 422 430
97. T. Ito, and R.T. Jensen Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin b (12), iron, and magnesium Curr Gastroenterol Rep 12 2010 448 457
98. R.T. Jensen Consequences of long-term proton pump blockade: highlighting insights from studies of patients with gastrinomas Basic Clin Pharmacol Toxicol 98 2006 4 19
99. M.J. Berna, B. Annibale, M. Marignani, T.V. Luong, V. Corleto, and A. Pace A prospective study of gastric carcinoids and enterochromaffin-like cells changes in multiple endocrine neoplaisa type 1 and Zollinger-Ellison syndrome: identification of risk factors J Clin Endocrinol Metab 93 2008 1582 1591
100. P.N. Maton, E.E. Lack, M.J. Collen, M.J. Cornelius, E. David, and J.D. Gardner The effect of Zollinger-Ellison syndrome and omeprazole therapy on gastric oxyntic endocrine cells Gastroenterology 99 1990 943 950
101. E.A. Lew, J.R. Pisegna, J.A. Starr, E.F. Soffer, C. Forsmark, and I.M. Modlin Intravenous pantoprazole rapidly controls gastric acid hypersecretion in patients with Zollinger-Ellison syndrome Gastroenterology 118 2000 696 704
102. M. Filopanti, U. Verga, F. Ermetici, L. Olgiati, C. Eller-Vainicher, and S. Corbetta MEN1-related hyperparathyroidism: response to cinacalcet and its relationship with the calcium-sensing receptor gene variant Arg990Gly Eur J Endocrinol 167 2012 157 164
103. P.N. Maton, J.D. Gardner, and R.T. Jensen Cushing's syndrome in patients with Zollinger-Ellison syndrome N Engl J Med 315 1986 1 5
104. G.C. Nikou, C. Toubanakis, P. Nikolaou, E. Giannatou, M. Safioleas, and E. Mallas VIPomas: an update in diagnosis and management in a series of 11 patients Hepatogastroenterology 52 2005 1259 1265
105. R.A. Wermers, V. Fatourechi, and L.K. Kvols Clinical spectrum of hyperglucagonemia associated with malignant neuroendocrine tumors Mayo Clin Proc 71 1996 1030 1038
106. R. Eldor, B. Glaser, M. Fraenkel, V. Doviner, A. Salmon, and D.J. Gross Glucagonoma and the glucagonoma syndrome - cumulative experience with an elusive endocrine tumour Clin Endocrinol (Oxf) 74 2011 593 598
107. G. Nesi, T. Marcucci, C.A. Rubio, M.L. Brandi, and F. Tonelli Somatostatinoma: clinico-pathological features of three cases and literature reviewed J Gastroenterol Hepatol 23 2008 521 526
108. L. Garby, P. Caron, F. Claustrat, P. Chanson, A. Tabarin, and V. Rohmer Clinical characteristics and outcome of acromegaly induced by ectopic secretion of growth hormone-releasing hormone (GHRH): a French nationwide series of 21 cases J Clin Endocrinol Metab 97 2012 2093 2104
109. L.I. Larsson, T. Schwartz, G. Lundqvist, R.E. Chance, F. Sundler, and J.F. Rehfeld Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors. Possible implication in the watery diarrhea syndrome Am J Pathol 85 1976 675 684