Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: Criteria, molecular concepts and clinical significance

Pathobiology

Volumn 74, Issue 5, 2007, Pages 279-284

  Anlauf, Martin ^a   Perren, Aurel ^b,c   Klöppel, Günter ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Endocrine tumor; Gastrinoma; Insulinoma; MEN1 mutation; Zollinger Ellison syndrome

Indexed keywords

GLUCAGON; INSULIN; PANCREAS POLYPEPTIDE;

DISEASE ASSOCIATION; DUODENUM GASTRINOMA; DUODENUM MICROADENOMA; GASTRIN CELL; GASTRINOMA; GENE DELETION; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; PANCREAS MICROADENOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SOMATOSTATINOMA; STEM CELL; TUMOR VOLUME; VON HIPPEL LINDAU DISEASE; ZOLLINGER ELLISON SYNDROME;

ADENOMA; CARCINOMA, NEUROENDOCRINE; DUODENAL NEOPLASMS; GASTRINOMA; HUMANS; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS;

EID: 34548860701     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000105810     Document Type: Review

References (24)

1. Huang SC, Koch CA, Vortmeyer AO, Pack SD, Lichtenauer UD, Mannan P, Lubensky IA, Chrousos GP, Gagel RF, Pacak K, Zhuang Z: Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas. Cancer Res 2000;60:6223-6226.
2. Koch CA, Huang SC, Moley JF, Azumi N, Chrousos GP, Gagel RF, Zhuang Z, Pacak K, Vortmeyer AO: Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma. Oncogene 2001;20:7809-7811.
3. Solcia E, Bordi C, Creutzfeldt W, et al: Histopathological classification of nonantral gastric endocrine growths in man. Digestion 1988;41:185-200.
4. Studer H, Derwahl M: Mechanisms of nonneoplastic endocrine hyperplasia - a changing concept: a review focused on the thyroid gland. Endocr Rev 1995;16:411-426.
5. Marx SJ, Simonds WF: Hereditary hormone excess: genes, molecular pathways, and syndromes. Endocr Rev 2005;26:615-661.
6. Burke AP, Federspiel BH, Sobin LH, Shekitka KM, Helwig EB: Carcinoids of the duodenum: a histologic and immunohistochemical study of 65 tumors. Am J Surg Pathol 1989;13:828-837.
7. Capella C, Riva C, Rindi G, et al: Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: a study of 44 cases. Endocr Pathol 1991;2:92-110.
8. Anlauf M, Garbrecht N, Henopp T, et al: Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinicopathological and epidemiological features. World J Gastroenterol 2006;12:5440-5446.
9. Zollinger RM, Ellison EH: Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 1955;142:709-723.
10. Norton JA, Fraker DL, Alexander HR, et al: Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med 1999;341:635-644.
11. Anlauf M, Perren A, Meyer CL, et al: Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology 2005;128:1187-1198.
12. Pipeleers-Marichal M, Somers G, Willems G, et al: Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med 1990;322:723-727.
13. Solcia E, Capella C, Fiocca R, Cornaggia M, Bosi F: The gastroenteropancreatic endocrine system and related tumors. Gastroenterol Clin North Am 1989;18:671-693.
14. Chandrasekharappa SC, Guru SC, Manickam P, et al: Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997;276:404-407.
15. Calender A, Morrison CD, Komminoth P, Scoazec JY, Sweet KM, Teh BT: Multiple endocrine neoplasia type 1; in DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds): Pathology and Genetics: Tumours of Endocrine Organs. WHO Classification of Tumors. Lyon, IARC Press, 2004, pp 218-227.
16. Anlauf M, Perren A, Henopp T, et al: Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. Gut 2007;56:637-644.
17. Klöppel G, Willemer S, Stamm B, Häcki WH, Heitz PU: Pancreatic lesions and hormonal profile of pancreatic tumors in multiple endocrine neoplasia type I: an immunocytochemical study of nine patients. Cancer 1986;57:1824-1832.
18. Thompson NW, Lloyd RV, Nishiyama RH, et al: MEN 1 pancreas: a histological and immunohistochemical study. World J Surg 1984;8:561-574.
19. Anlauf M, Schlenger R, Perren A, et al: Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol 2006;30:560-574.
20. Le Bodic MF, Heymann MF, Lecomte M, et al: Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I. Am J Surg Pathol 1996;20:1378-1384.
21. Vortmeyer AO, Huang S, Lubensky I, Zhuang Z: Non-islet origin of pancreatic islet cell tumors. J Clin Endocrinol Metab 2004;89:1934-1938.
22. Perren A, Anlauf M, Henopp T, et al: Multiple endocrine neoplasia type 1: loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters, but not in islet hyperplasia of the pancreas: a combined FISH and immunofluorescence study. J Clin Endocrinol Metab 2006, E-pub ahead of print.
23. Chetty R, Kennedy M, Ezzat S, Asa SL: Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions. Endocr Pathol 2004;15:141-148.
24. Lubensky IA, Pack S, Ault D, et al: Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients: histopathological and molecular genetic analysis. Am J Pathol 1998;153:223-231.