Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2781-2786

  James, Clint A ^a   Deroy, Patrick ^a   Duplessis, Martin ^a   Edwards, Paul J ^a   Halmos, Teddy ^a   Minville, Joannie ^a   Morency, Louis ^a   Morin, Sébastien ^a   Simoneau, Bruno ^a   Tremblay, Martin ^a   Bethell, Richard ^a   Cordingley, Michael ^a   Duan, Jianmin ^a   Lamorte, Louie ^a   Pelletier, Alex ^a   Rajotte, Daniel ^a   Salois, Patrick ^a   Tremblay, Sonia ^a   Sturino, Claudio F ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Benzofuranopyrimidone; HIV 1; NcRTI; Nucleotide competing; Reverse transcriptase

Indexed keywords

AMINE; ANTIVIRUS AGENT; BENZOFURANO[3,2 D]PYRIMIDIN 2 ONE; FURANONE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PHYSICAL CHEMISTRY;

BENZOFURANS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MICROSOMES, LIVER; NUCLEOTIDES; PROTEIN BINDING; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876101790     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.021     Document Type: Article

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