A rex family transcriptional repressor influences H2O2 accumulation by Enterococcus faecalis

Journal of Bacteriology

Volumn 195, Issue 8, 2013, Pages 1815-1824

  Vesić, Dušanka ^a   Kristich, Christopher J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN EF2638; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANAEROBIC GROWTH; ANAEROBIC METABOLISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DETOXIFICATION; DNA BINDING; ENTEROCOCCUS FAECALIS; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PURIFICATION; UPREGULATION; WILD TYPE;

BACTERIAL PROTEINS; ENTEROCOCCUS FAECALIS; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; HOMEOSTASIS; HYDROGEN PEROXIDE; MUTATION; NAD; OXIDATION-REDUCTION; PROTEIN ARRAY ANALYSIS; PROTEIN BINDING; REPRESSOR PROTEINS; TRANSCRIPTOME;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; POSIBACTERIA;

EID: 84876088340     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.02135-12     Document Type: Article

References (43)

1. de Graef MR, Alexeeva S, Snoep JL, Teixeira de Mattos MJ. 1999. The steady-state internal redox state (NADH/NAD) reflects the external redox state and is correlated with catabolic adaptation in Escherichia coli. J. Bacteriol. 181:2351-2357.
2. Pagels M, Fuchs S, Pane-Farre J, Kohler C, Menschner L, Hecker M, McNamarra PJ, Bauer MC, von Wachenfeldt C, Liebeke M, Lalk M, Sander G, von Eiff C, Proctor RA, Engelmann S. 2010. Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol. Microbiol. 76:1142-1161.
3. + binding in solution. J. Mol. Biol. 408:670-683.
4. Wang E, Bauer MC, Rogstam A, Linse S, Logan DT, von Wachenfeldt C. 2008. Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. Mol. Microbiol. 69:466-478.
5. Sickmier EA, Brekasis D, Paranawithana S, Bonanno JB, Paget MS, Burley SK, Kielkopf CL. 2005. X-ray structure of a Rex-family repressor/ NADH complex insights into the mechanism of redox sensing. Structure 13:43-54.
6. + redox sensing by a Rex family repressor. Mol. Cell 38:563-575.
7. + redox poise in Streptomyces coelicolor A3(2). EMBO J. 22:4856-4865.
8. +) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis. J. Bacteriol. 188:7062-7071.
9. Bitoun JP, Nguyen AH, Fan Y, Burne RA, Wen ZT. 2011. Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans. FEMS Microbiol. Lett. 320:110 -117.
10. Ravcheev DA, Li X, Latif H, Zengler K, Leyn SA, Korostelev YD, Kazakov AE, Novichkov PS, Osterman AL, Rodionov DA. 2012. Transcriptional regulation of central carbon and energy metabolism in bacteria by redox-responsive repressor Rex. J. Bacteriol. 194:1145-1157.
11. Murray BE. 1990. The life and times of the Enterococcus. Clin. Microbiol. Rev. 3:46-65.
12. Tannock GW, Cook G. 2002. Enterococci as members of the intestinal microflora of humans, p 101-132. In Gilmore MS, Clewell DB, Courvalin P, Dunny GM, Murray BE, Rice LB (ed), The enterococci: pathogenesis, molecular biology, and antibiotic resistance. American Society for Microbiology Press, Washington, DC.
13. Huycke MM, Moore DR. 2002. In vivo production of hydroxyl radical by Enterococcus faecalis colonizing the intestinal tract using aromatic hydroxylation. Free Radic. Biol. Med. 33:818-826.
14. Huycke MM, Abrams V, Moore DR. 2002. Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA. Carcinogenesis 23:529 -536.
15. Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM. 2003. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science 299:2071-2074.
16. Ross RP, Claiborne A. 1997. Evidence for regulation of the NADH peroxidase gene (npr) from Enterococcus faecalis by OxyR. FEMS Microbiol. Lett. 151:177-183.
17. Claiborne A, Ross RP, Parsonage D. 1992. Flavin-linked peroxide reductases: protein-sulfenic acids and the oxidative stress response. Trends Biochem. Sci. 17:183-186.
18. Pugh SY, Knowles CJ. 1983. Synthesis of catalase by "Streptococcus faecalis subsp. Zymogenes." Arch. Microbiol. 136:60-63.
19. Frankenberg L, Brugna M, Hederstedt L. 2002. Enterococcus faecalis heme-dependent catalase. J. Bacteriol. 184:6351- 6356.
20. Britton L, Malinowski DP, Fridovich I. 1978. Superoxide dismutase and oxygen metabolism in Streptococcus faecalis and comparisons with other organisms. J. Bacteriol. 134:229 -236.
21. Patel MP, Marcinkeviciene J, Blanchard JS. 1998. Enterococcus faecalis glutathione reductase: purification, characterization and expression under normal and hyperbaric O2 conditions. FEMS Microbiol. Lett. 166: 155-163.
22. Gold OG, Jordan HV, van Houte J. 1975. The prevalence of enterococci in the human mouth and their pathogenicity in animal models. Arch. Oral Biol. 20:473- 477.
23. Vesic D, Kristich CJ. 2012. MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis. Antimicrob. Agents Chemother. 56: 2443-2451.
24. Maguin E, Duwat P, Hege T, Ehrlich D, Gruss A. 1992. New thermosensitive plasmid for Gram-positive bacteria. J. Bacteriol. 174:5633-5638.
25. Kristich CJ, Chandler JR, Dunny GM. 2007. Development of a hostgenotype- independent counterselectable marker and a high-frequency conjugative delivery system and their use in genetic analysis of Enterococcus faecalis. Plasmid 57:131-144.
26. Thurlow LR, Thomas VC, Hancock LE. 2009. Capsular polysaccharide production in Enterococcus faecalis and contribution of CpsF to capsule serospecificity. J. Bacteriol. 191:6203- 6210.
27. Debroy S, van der Hoeven R, Singh KV, Gao P, Harvey BR, Murray BE, Garsin DA. 2012. Development of a genomic site for gene integration and expression in Enterococcus faecalis. J. Microbiol. Methods 90:1- 8.
28. Le Breton Y, Muller C, Auffray Y, Rince A. 2007. New insights into the Enterococcus faecalis CroRS two-component system obtained using a differential- display random arbitrarily primed PCR approach. Appl. Environ. Microbiol. 73:3738 -3741.
29. O'Sullivan DJ, Klaenhammer TR. 1993. High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening. Gene 137:227-231.
30. O'Sullivan DJ, Walker SA, West SG, Klaenhammer TR. 1996. Development of an expression strategy using a lytic phage to trigger explosive plasmid amplification and gene expression. Biotechnology 14:82- 87.
31. Kristich CJ, Manias DA, Dunny GM. 2005. Development of a method for markerless genetic exchange in Enterococcus faecalis and its use in construction of a srtA mutant. Appl. Environ. Microbiol. 71:5837-5849.
32. Leonardo MR, Dailly Y, Clark DP. 1996. Role of NAD in regulating the adhE gene of Escherichia coli. J. Bacteriol. 178:6013- 6018.
33. Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, Formsma K, Gerdes S, Glass EM, Kubal M, Meyer F, Olsen GJ, Olson R, Osterman AL, Overbeek RA, McNeil LK, Paarmann D, Paczian T, Parrello B, Pusch GD, Reich C, Stevens R, Vassieva O, Vonstein V, Wilke A, Zagnitko O. 2008. The RAST server: rapid annotations using subsystems technology. BMC Genomics 9:75.
34. Frank KL, Barnes AM, Grindle SM, Manias DA, Schlievert PM, Dunny GM. 2012. Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis. Infect. Immun. 80:539 -549.
35. Hecker M, Reder A, Fuchs S, Pagels M, Engelmann S. 2009. Physiological proteomics and stress/starvation responses in Bacillus subtilis and Staphylococcus aureus. Res. Microbiol. 160:245-258.
36. Larsson JT, Rogstam A, von Wachenfeldt C. 2005. Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis. Microbiology 151:3323-3335.
37. Mehmeti I, Jonsson M, Fergestad EM, Mathiesen G, Nes IF, Holo H. 2011. Transcriptome, proteome, and metabolite analyses of a lactate dehydrogenase- negative mutant of Enterococcus faecalis V583. Appl. Environ. Microbiol. 77:2406 -2413.
38. Bizzini A, Zhao C, Budin-Verneuil A, Sauvageot N, Giard JC, Auffray Y, Hartke A. 2010. Glycerol is metabolized in a complex and strain-dependent manner in Enterococcus faecalis. J. Bacteriol. 192: 779 -785.
39. Deutscher J, Bauer B, Sauerwald H. 1993. Regulation of glycerol metabolism in Enterococcus faecalis by phosphoenolpyruvate-dependent phosphorylation of glycerol kinase catalyzed by enzyme I and HPr of the phosphotransferase system. J. Bacteriol. 175:3730 -3733.
40. Seaver LC, Imlay JA. 2001. Hydrogen peroxide fluxes and compartmentalization inside growing Escherichia coli. J. Bacteriol. 183:7182-7189.
41. Fuchs S, Pane-Farre J, Kohler C, Hecker M, Engelmann S. 2007. Anaerobic gene expression in Staphylococcus aureus. J. Bacteriol. 189: 4275-4289.
42. Messner KR, Imlay JA. 2002. Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase. J. Biol. Chem. 277:42563-42571.
43. La Carbona S, Sauvageot N, Giard JC, Benachour A, Posteraro B, Auffray Y, Sanguinetti M, Hartke A. 2007. Comparative study of the physiological roles of three peroxidases (NADH peroxidase, alkyl hydroperoxide reductase and thiol peroxidase) in oxidative stress response, survival inside macrophages and virulence of Enterococcus faecalis. Mol. Microbiol. 66:1148 -1163.