Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis

Science

Volumn 299, Issue 5615, 2003, Pages 2071-2074

  Paulsen, I T ^a,b   Banerjei, L ^a   Hyers, G S A ^a   Nelson, K E ^a   Seshadri, R ^a   Read, T D ^a   Fouts, D E ^a   Eisen, J A ^a,b   Gill, S R ^a   Heidelberg, J F ^a   Tettelin, H ^a   Dodson, R J ^a   Umayam, L ^a   Brinkac, L ^a   Beanan, M ^a   Daugherty, S ^a   DeBoy, R T ^a   Durkin, S ^a   Kolonay, J ^a   Madupu, R ^a   Nelson, W ^a   Vamathevan, J ^a   Tran, B ^a   Upton, J ^a   Hansen, T ^a   Shetty, J ^a   Khouri, H ^a   Utterback, T ^a   Radune, D ^a   Ketchum, K A ^a,d   Dougherty, B A ^a,e   Fraser, C M ^a,c   more..

^a J CRAIG VENTER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d CELERA GENOMICS   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; ENZYME INHIBITION; GENES;

MOBILE ELEMENTS;

DNA;

DNA; VANCOMYCIN;

DNA; GENOME;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENTEROCOCCUS FAECALIS; GENE SEQUENCE; MOLECULAR EVOLUTION; NONHUMAN; OXIDATIVE STRESS; PLASMID; PREDICTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADHESINS, BACTERIAL; BACTERIAL ADHESION; BACTERIAL PROTEINS; CARRIER PROTEINS; CHROMOSOMES, BACTERIAL; CONJUGATION, GENETIC; CONSERVED SEQUENCE; DIGESTIVE SYSTEM; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROCOCCUS FAECALIS; EVOLUTION; GENE TRANSFER, HORIZONTAL; GENOME, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; LYSOGENY; OPEN READING FRAMES; OXIDATIVE STRESS; PLASMIDS; SEQUENCE ANALYSIS, DNA; SYNTENY; VANCOMYCIN RESISTANCE; VIRULENCE; VIRULENCE FACTORS;

ENTEROCOCCUS FAECALIS; NEGIBACTERIA; PROKARYOTA;

EID: 0037470983     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080613     Document Type: Article

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21. This work was supported by the NIH, National Institute of Allergy and Infectious Disease Grant AI40963-02. We thank M. Heaney, S. Lo, M. Holmes, B. Lee, R. Karamchedu, and V. Sapiro for database and information technology support at TIGR, and we thank the TIGR faculty and sequencing core for expert advice and assistance. We thank M. Gilmore for generously providing E. faecalis V583. We thank D. Clewell for providing the complete sequence of pAD1 for comparative analysis.