Oxidative stress-mediated renal dysfunction by cyclosporine a in rats: Attenuation by trimetazidine

Renal Failure

Volumn 24, Issue 3, 2002, Pages 259-274

  Satyanarayana, Padi S V ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Cyclosporine A (CsA); Nephrotoxicity; Oxidative stress; Trimetazidine

Indexed keywords

CYCLOSPORIN A; LIPID PEROXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIMETAZIDINE; BIOLOGICAL MARKER; CREATININE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; FEMALE; GLOMERULUS BASEMENT MEMBRANE; KIDNEY FUNCTION; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DISEASE MODEL; DRINKING; DRUG COMBINATION; DRUG EFFECT; GLOMERULUS FILTRATION RATE; KIDNEY; KIDNEY DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SYSTOLE; TIME; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL; URINE; WISTAR RAT;

ANIMAL; BIOLOGICAL MARKERS; BLOOD PRESSURE; BLOOD UREA NITROGEN; BODY WEIGHT; COMPARATIVE STUDY; CREATININE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; DRINKING; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SYSTOLE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS; TREATMENT OUTCOME; TRIMETAZIDINE; VASODILATOR AGENTS; ANIMALS;

EID: 0036022101     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-120005360     Document Type: Article

References (40)

1. Cyclosporine
2. Acute effects of cyclosporine on renal function in healthy humans
3. Mechanisms of acute and chronic nephrotoxicity from immunosuppressive drugs
4. Chronic cyclosporine nephrotoxicity
5. Increased urinary excretion of lipid peroxide levels in renal transplant patients
6. Oxygen radical formation during cytochrome p450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations
7. Cyclosporine produces endothelial dysfunction by increased production of superoxide
8. Cyclosporine A-induced hydrogen peroxide synthesis by cultured human mesangial cells is blocked by exogenous antioxidants
9. Dietary glycine and renal denervation prevents cyclosporine a-induced hydroxyl radical production in rat kidney
10. Mechanisms of cyclosporine A-induced vasoconstriction in the isolated perfused rat kidney
11. Effect of cyclosporin a analogues on cytosolic calcium and vasoconstriction: Possible lack of relationship to immunosuppressive activity
12. Cyclosporine a inhibits ATP net uptake of rat kidney mitochondria
13. Modulation of energy status and cytotoxicity induced by FK 506 and cyclosporine A in a renal epithelial cell line
14. Effects of trimetazidine on metabolic and functional recovery of post ischemic rat hearts
15. Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine a isolated rat liver mitochondria
16. Effect of trimetazidine on lipid peroxidation and phosphorous metabolites during cold storage and reperfusion of isolated rat perfused kidneys
17. Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells
18. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction
19. Lipid peroxidation accompanies cyclosporine nephrotoxicity: Effects of vitamin E
20. Cyclosporine A-induced alterations in magnesium homeostasis in the rat
21. Low-dose cyclosporine nephrotoxicity in the rat
22. Induction of renal growth and injury in intact rat kidney by dietary deficiency of antioxidants
23. Possible role lipid peroxidation in cyclosporine nephrotoxicity
24. Role of reactive oxygen formation in the cyclosporin-a-mediated impairment of renal functions
25. Evidence that alteration in renal metabolism and lipid peroxidation may contribute to nephrotoxicity
26. Cyclosporin a increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine
27. Intravenous cyclosporine activates afferent and efferent nerves and causes sodium retention in innervated kidneys in rats
28. Effect of cyclosporine administration on renal hemodynamics in conscious rats
29. Cyclosporine a up-regulates angiotensin II receptors and calcium responses in human vascular smooth muscle cells
30. α-lipoic acid: A metabolic antioxidant which regulates NF-κB signal transduction and protects against oxidative injury
31. Cyclosporine A-induced lipid peroxidation and influence on glucose-6-phosphatase in rat hepatic and renal microsomes
32. Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion ischemic hypertrophied rat myocardium
33. Improvement of the long-term preservation of the isolated arrested rat heart by trimetazidine: Effects on the energy state and mitochondrial function
34. Trimetazidine reduces renal dysfunction by limiting the cold ischemia-reperfusion injury in autotransplanted pig kidneys
35. Cytoprotective effect of trimetazidine on 75 min warms renal ischemia-reperfusion injury in rats
36. Cyclosporine-induced acute renal dysfunction in the rat. Evidence of arteriolar vasoconstriction with preservation of tubular function
37. Involvement of reactive oxygen species in kidney damage
38. Oxygen free radical mediated renal dysfunction
39. Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporin A
40. Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis